Menene Glutamate?
Ma'anar:
Glutamate wani nau'i ne na kwakwalwar kwakwalwa wanda ake kira neurotransmitter , wanda ke nufin yana taimakawa wajen aika saƙonni a kwakwalwa. Ana amfani da ita a koyo da ƙwaƙwalwar ajiya. Glutamate yana da hannu a yawan cututtuka masu yawa.
Har ila yau Known As: L-glutamic acid, glutamic acid, L-glutamate
Sau da yawa rikicewa tare da: Glutamine
Glutamate yana yin wasu ayyuka masu muhimmanci a kwakwalwarka.
An dauke shi ne mai daukar nauyin haɗari, wanda ke nufin shi yana motsa wurare a cikin kwakwalwa ko wasu sassan tsarin jin tsoro. Wannan nau'i na motsa jiki shine muhimmin ɓangare na tsarin ilmantarwa, don haka a wannan hanya, glutamate abu ne mai kyau.
Duk da haka, kuri'a na glutamate ba dole ba ne abin da kake so. A wasu lokuta, zai iya zama abin da ake kira excitotoxin. "Toxin" ba shi da wata kalma mai kyau, kuma babu tabbas a wannan yanayin. A matsayinsa na fitinar, glutamate zai iya rinjayar kwakwalwar kwakwalwarka.
Idan matakan da ba a sa su ba, wannan neurotransmitter zai iya rinjayar wadannan kwayoyin har sai sun dauki mummunan aiki kuma su kashe kansa don kare rayukan da suke kewaye da su. (Ka yi la'akari da shi kamar cirewa haƙori na haɗi don haka lalata ba ta yada zuwa hakora kusa da shi ba.)
Sel a jikinmu yana mutuwa duk lokacin, kuma mafi yawansu za a iya maye gurbin su. Wadanda wadanda ke amfani da shi don su kashe kansa, duk da haka, sune ne.
Kwajinka ba zai iya sa sababbin su maye gurbin waɗanda suka rasa ba, don haka yana da muhimmanci a kiyaye su lafiya da lafiya.
Matsayin Glutamate a matsayin excitotoxin an yi imani da cewa yana da hannu a wasu cututtuka da ke tattare da neurodegenerative irin su sclerosis da yawa, cututtukan Alzheimer da amyotrophic labaran sclerosis (wanda aka sani da cutar ALS ko Lou Gherig).
Gyutamate dysregulation kuma an yi la'akari da zama wani ɓangare na fibromyalgia da kuma ciwo mai wuya ciwo , ko da yake waɗannan yanayi ba la'akari da neurodegenerative.
Glutamate & Fibromyalgia
Bincike ya nuna cewa mutanen da ke da fibromyalgia suna da mummunan matakan yaduwa a fannin kwakwalwa da ake kira insula ko ɓoye na jikin mutum. Ƙungiyar tana da hannu sosai wajen sarrafa duka ciwo da haɗari. Matakan mai girma suna nuna alama cewa wannan yankin na kwakwalwa na iya zama wanda ba shi da yawa a cikin wannan yanayin.
Har ila yau, insula yana cikin:
- hankulan
- damuwa
- dabarun motar
- cravings
- cin abinci
- buri
A fibromyalgia, shigarwar shigar da kwayar halitta zai iya ƙaruwa, yana haifar da overstimulation . Raguwa shine wata alama ce ta yau da kullum. Ƙwararrakin motsa jiki na iya zama matsala, yana haifar da matsalar matsala da dama . Rashin ciwo zai iya zama mafi yawan mutane a cikin fibromyalgia, haka nan.
Glutamate yana cikin yankunan jiki a waje da tsarin jin dadi, inda yake aiki a matsayin hormone. A wannan rawar, zai iya haifar da ciwo.
Nazarin shekara ta 2016 ya nuna cewa motsa jiki na iya rage yawan ciwon guttura a cikin mutane tare da fibromyalgia, wanda zai iya taimakawa wajen bayyana dangantakar da ba a fahimta ba tsakanin wannan yanayin da aiki .
Glutamate a cikin Ciwo Cutar Gishiri
Nazarin ya bambanta game da yaduwar dysregulation mai yalwaci yana taka muhimmiyar rawa cikin ciwo mai wuya, yanayin da ya hada da rikice-rikice, damuwa, da matsalolin motsi / daidaitawa .
Ya bambanta da fibromyalgia, duk da haka, binciken ya nuna cewa matakan glutamate na iya zama ƙasa a wasu yankuna na kwakwalwa. Wannan yana da mahimmanci lokacin da kake tunanin ƙwaƙwalwar kwakwalwa da ke fama da wannan cuta, wanda ya haɗa da matsaloli tare da ilmantarwa.
Har ila yau, muna da wasu shaidu na nuna cewa ciwo na gajiya na yau da kullum zai iya haɗawa da kwayoyin da suke da alaƙa da dysregulation.
Monosodium Glutamate
A matsayin amino acid, glutamate wani ɓangare ne na monosodium glutamate (MSG), wadda aka yi amfani da shi a wasu magunguna da kuma azaman abincin abinci.
Yana iya kasancewa da alaka da wasu cututtukan lafiyar lafiya.
Wasu likitocin kiwon lafiya sunyi imanin cewa MSG na iya cutar da mutane da fibromyalgia, yayin da wasu sun gaskanta ba. Wasu mutane sun ce kawar da MSG daga abincin su ya taimaka wajen kawar da bayyanar cututtuka na fibromyalgia da kuma ciwo mai wuya, amma waɗannan ikirarin ba su tabbatar da kimiyya ba.
Glutamate & Sauran Neurotransmitters
Kuna iya yin mamakin yadda kwakwalwarka ke hulɗar da manyan matakan glutamate. Yana da wani bayani-wani mai ba da rahotanni mai suna GABA. Ayyukan GABA shine a kwantar da kwakwalwarka bayan guttura ya ba shi duka.
Yana da mahimmanci ga matakan GABA da glutamate su zama daidai da juna, amma wannan ba sau daya ba ne a cikin rashin lafiya mai kamala.
Sauran masu ba da agaji da ke cikin waɗannan yanayi sun haɗa da:
Hannestad U, Theodorsson E, Evengård B. International jarida na asibitin chemisty. 2007 Feb; 376 (1-2): 23-9. Beta-Alanine da kuma gamma-Aminobutyric acid a cikin ciwo na gajiya.
Harris RE, et. al. Arthritis da rheumatism. 2009 Oktoba; 60 (10): 3146-52. An yi amfani da glutamate mai launi a cikin fibromyalgia tare da gwajin gwaji.
Kuratsune H, Yamaguti K, Lindh G, et al. NeuroImage. > 2002 Nov; 17 (3): 1256-65. Yankuna na Brain sun haɗu da haɗari gajiya: rage acetylcarnitine shiga cikin kwakwalwa.
> Martins DF, Siteneski A, Ludtke DD, et al. Neurobiology kwayoyin halitta. 2016 Sep 13. [Epub gaban bugawa] Harkokin gwagwarmayar kwarewa na rage yawan kullun da aka yiwa yatsun kafa ta hanyar kunna masu karbaccen g-protein-guda biyu da ke hana haɓin phosphorylated protein kinase a.
Smith AK, Fang H, Whistler T, et al. Neuropsychobiology. > 2011; 64 (4): 183-94. Ƙwararrun kwayoyin halitta masu bincike suna nuna ƙungiyar GRIK2 da NPAS2 tare da ciwo mai wuya.