Ayyukan da Suke Yi, Wace Matsala Za Su iya Sawa
GABA da glutamate sune neurotransmitters- jakadun magunguna a cikin kwakwalwarka. Ɗaya daga cikinsu yana jin dadi, wanda yana mai da hankali, kuma sun kamata su kasance cikin daidaitawa da juna. Don me menene ya faru idan an kashe wannan ma'auni?
Wasu bincike sun nuna rashin daidaituwa ga waɗannan abubuwa guda biyu na iya taka rawa wajen fibromyalgia (FMS). Bincike bai da tushe sosai a kan yadda suke shiga cikin ciwo na rashin lafiya ( ME / CFS ), tare da wasu nazarin binciken da ke nuna dysregulation da sauransu basu gano kome ba.
A cikin Brain
Kwallon kwakwalwar mutum yana da wuyar ganewa. Kowace ƙungiyar ta neurotransmitter na aiki da ayyuka masu yawa, kuma suna hulɗa da juna da ƙananan ƙananan ƙwayoyinku (ƙwaƙwalwar kwakwalwa) a cikin wani ƙananan hanyar da ba mu fahimta ba.
Duk da haka, muna ci gaba da koyo game da kwakwalwa kuma masu bincike sun iya haɗakar wasu ƙananan ƙwayoyin cuta zuwa wasu cututtuka ko bayyanar cututtuka. Sun kuma samo hanyoyin da za su canza aikin neurotransmitter kuma zai iya ganin ainihin tasirin da yake da shi a kan batutuwan bincike.
Kwaƙwalwar kwakwalwa tana da kyau a sake sarrafa, sau da yawa ta amfani da neurotransmitter guda ɗaya don ƙirƙirar wani. Wannan aikin yana da ma'ana lokacin da kake magana game da masu ba da agaji tare da ayyuka masu ban sha'awa, irin su GABA da glutamate. Mafi sanannun serotonin da melatonin biyu wani misali ne, kamar yadda ake kira norepinephrine da dopamine. Dukkan waɗannan wadanda ba su nema ba ne ana ganin sun zama dysregulated a cikin waɗannan yanayi.
Lokacin da ɗaya neurotransmitter a cikin biyu ba shi da ma'auni, zai iya watsar da ɗaya daga ma'auni, kazalika.
Glutamate
Glutamate shine nau'i na mai jin daɗin kwakwalwa. Ɗaya daga cikin ayyukansa na farko ita ce samun wasu ƙwayoyin kwakwalwa. Yana kara su don su iya yin abubuwa masu mahimmanci kamar su koyi sabon bayani ko yin tunani-wasu abubuwa da ake amfani da glutamate.
Duk da haka, mai ba da jin dadin da ba ya daina yin maka sigar abu yana ciwo bayan dan lokaci. Yawancin abubuwan da ke da mahimmanci ba abu ne mai kyau ba, kamar yadda duk wanda yake bugu da ƙura mai yawa zai iya fada maka. A wasu lokuta, glutamate na iya zama abin da ake kira "excitotoxin," ma'ana cewa wani lokaci yana nuna sabbin kayan aiki har sai sun kashe kansa.
Halin da zai iya haifar da mutuwar kwakwalwar kwayoyin halitta dalilin da ya sa aka yarda da amfani da glutamate a wasu cututtukan kwakwalwa na ciki irin su cutar Alzheimer da cutar amyotrophic na gefe (ALS ko Lou Gehrig.) (Lura: FMS da ME / CFS ba su yarda da su ba. zama degenerative.)
A cikin FMS, bincike yana nuna matakan ƙananan nauyin glutamate a cikin wani ɓangare na kwakwalwa da ake kira insula ko ɓoye na jikin mutum. Masu binciken sun tafi neman wurin domin wannan yankin yana da ciwo sosai da zafi da halayensa, waxanda suke da mahimman bayanai na yanayin. Har ila yau, insula ma yana da tasiri a hankali, basirar motar, damuwa, ci abinci, da jaraba.
Binciken bincike ya haɗa da matakan da ke ciki da rashin tausayi da rashin aiki mai kwakwalwa a cikin mutanen da suka kamu da ciwon sukari. (Glutamate za a iya samuwa daga glucose, wanda yawanci yake a cikin masu ciwon sukari.) Akalla shirin binciken FMS ya nuna cewa rage matakan glutamate zai iya rage zafi.
An yi amfani da samfurin kwakwalwa na ƙwayar cuta saboda yawancin alamun bayyanar cututtuka, ciki har da:
- hyperalgesia (maganin zafi, fasalin alama na FMS)
- damuwa
- rashin natsuwa
- ADHD-kamar bayyanar cututtuka, kamar rashin yiwuwar mayar da hankali
A cikin ME / CFS, wasu masu bincike sunyi zaton cewa aikin glutamate yana da ƙasa, wanda ke nufin kwakwalwa baya samun ƙarfin da ya dace. Duk da haka, wannan shaida bai rigaya goyan bayan shaida ba.
Kusan rashin daidaituwa cikin kwakwalwa an yi imanin ya haifar da bayyanar cututtuka ciki har da:
- rashin barci
- matsalolin taro
- ciwon tunani
- low makamashi
GABA
GABA tana nufin gamma-amino-n-butyric acid. Kwajinka yana amfani da kullun don samar da GABA.
Ayyukan farko na GABA shine kwantar da kwakwalwarka.
Har ila yau, ya shafi barci, shakatawa, tsari da juyayi.
GABA an yi imanin kasancewa ko rashin amfani a cikin FMS. Ya zuwa yanzu, bincike ba ya bayar da shawarar dasregulation GABA a ME / CFS ba.
Saboda GABA da zumunta kusa da glutamate, alamun kwakwalwar kwakwalwa GABA rashi na iya zama kamar, ko kuma tare da shi, wadanda ke cikin kwakwalwa.
Gano Balance
Idan ka yi tsammanin GABA / glutamate dysregulation yana haifar da wasu daga cikin alamar cututtuka, magana da likitanka game da shi. Akwai kwayoyi, kariyan, da canje-canjen abincin da zai taimaka maka samun daidaitattun daidaituwa. Kuna iya gano wadannan zaɓuɓɓuka a nan:
Sources:
Hannestad U, Theodorsson E, Evengård B. International jarida na asibitin chemisty. 2007 Feb; 376 (1-2): 23-9. Epub 2006 Jul 14. Beta-Alanine da kuma gamma-Aminobutyric acid a cikin ciwo mai wahala ciwo.
Harris RE, et. al. Arthritis da rheumatism. 2009 Oktoba; 60 (10): 3146-52. An yi amfani da glutamate mai launi a cikin fibromyalgia tare da gwajin gwaji.
Harris RE, et. al. Arthritis da rheumatism. 2008 Mar; 58 (3): 903-7. Matakan cike da yaduwa a cikin mahaifa suna haɗuwa tare da cigaba a cikin yankuna masu zafi a fibromyalgia.
> Lyoo IK, et. al. Tarihin magunguna. 2009 Aug; 66 (8): 878-87. Yayi gyare-gyaren gwargwadon gubar dalutamate-glutamine-gamma-aminobutyric acid kuma ya danganta da ƙananan ƙin zuciya da kuma cututtuka masu bayyanar cututtuka a irin su 1 ciwon sukari.
Murkushe JW, et. al. NMR a biomedicine. 2010 Jul; 23 (6): 643-50. Ƙara yawan ƙwayar ventricular a cikin ciwo mai wuya mai tsanani wanda aka auna ta 1H MRS a hoto a 3.0 T. II: kwatanta tare da babban cututtuka.