Menene aikinsa?
Kumburi yana daya daga cikin mawuyacin haddasa ciwo, amma yana da nasaba da zafi na fibromyalgia ?
Matsayin da kumburi a cikin wannan yanayin ya kasance batun bincike da muhawara don shekarun da suka gabata. A gaskiya ma, yanayin da ake kira "fibrositis," wanda ke nufin "ƙurar fibrous-nama." Amma a tsawon lokaci, ƙananan rashin ciwon kullun ya haifar da al'ummar likita don ganin fibromyalgia ("fibrous-tissue and muscle pain") a matsayin karin lokaci.
Bayan 'yan shekarun da suka gabata, duk da haka, muna kallon kullun a cikin wannan yanayin, godiya ga wani aiki mai girma wanda ya nuna cewa yana iya taka rawa, bayan duk. Wannan binciken na iya haifar da kyakkyawar fahimtar rashin lafiya da kuma yadda za a iya zazzage zaɓuɓɓukan magani.
Me ya sa rikici?
Masanan likitoci sun yarda da fibromyalgia ba wani cututtuka ba ne saboda ba shi da mafi yawan cututtukan ƙwayar cuta. Jigogi ba su bayyana kumbura ko zafi. Kwafin gwaje-gwaje na alamomin mai ƙyama, wanda ya nuna matakai masu girma a cikin cututtuka irin su lupus da arthritis , ya nuna al'amuran al'ada ko kadan kawai a fibromyalgia. A shekara ta 2012, masu bincike suna nazarin maganin ƙwaƙwalwar ƙwayoyin cuta (cututtukan cututtuka) wanda ake kira fibromyalgia "falsafar ƙananan ƙwayoyin cuta".
Bugu da ƙari, ƙwayoyin anti-inflammatory-dukansu corticosteroids da wadanda basu da magungunan cututtukan steroidal (NSAIDs) - sukan kasance marasa amfani a rage yawan ciwo na fibromyalgia .
To, ina ne batun kumburi ya shigo?
A Case na Kumburi
A cikin 'yan shekarun nan, masu bincike sun koyi abubuwa masu yawa game da ƙwaƙwalwar da ake ciki a wannan yanayin.
A cikin bazarar shekara ta 2017, jaridar Journal of Pain Research ya wallafa wani binciken da ya kalli maganin proteins 92 da aka sani da alaka da kumburi.
Masu bincike sun ce shi ne "binciken mafi yawan ... ilimin ƙaddamar da lalata ga marasa lafiya na FM har zuwa yanzu." Sun bayar da shaida mai yawa na kumburi. Ba wai kawai ba, amma shaidun shaida suna nuna kumburi a cikin tsarin tsakiya na tsakiya (kwakwalwa da jijiyoyin jijiyoyin) da kuma tsarin jiki.
Wannan aikin ya tabbatar da binciken farko da ya nuna cewa wasu kwayoyin daga tsarin kwayoyin, wanda ake kira cytokines , suna da girma a cikin mutane da fibromyalgia. Wannan yana goyon bayan tsammanin wannan yanayin ya shafi dysregulation na rigakafi.
Tsarin tsakiya na tsakiya yana da tsarin kansa, wanda ya bambanta daga sauran jikin, kuma binciken ya nuna matakan matakan kwayoyin da ake kira chemokines, da.
Nazarin nazarin 2010 na Genevra Liptan, MD, ya nuna cewa zai iya zama fasalin-wani nau'i mai launi na kayan haɗin kai wanda ke kewaye da mafi yawancin cikin gida-wannan yana cike da fibromyalgia. Mai binciken ya ƙaddamar da cewa lalacewa mai ƙyama da ƙumburi zai iya zama abin da ke haifar da tsaka-tsakin tsakiyar , wanda aka yi la'akari da zama babban ɓangaren rashin lafiya.
Hanyar tsakiya ta tsakiya tana faruwa ne lokacin da tsarin kulawa na tsakiya ya zama mai karfin jini-kuma ya sake haifar da shigarwa, ciki har da ciwo da sauran abubuwan da hankalinka suka gano, irin su haske, amo , da ƙanshi .
An yi imanin cewa a kalla a wasu lokuta ne sakamakon lalata ciwo na sakonni yana bombarding kwakwalwa da ƙwararre.
Nazarin binciken na 2012 a cikin Neuroimmunomodulation yayi bincike game da rawar da za a iya aiwatarwa a cikin fibromyalgia. Masu bincike sun gano cewa akwai wani mummunar jiha wanda ya zama kamar abin da yake da alaka da wani matsala mai mahimmanci ga damuwa. Ba su iya yin ƙayyade ko ƙonewa ya haifar da damewa ba ko kuma mataimakin.
A shekara ta 2013, masu bincike na Spaniya wanda jagorancin MD Cordero suka jagoranci sunyi zaton cewa ƙonewa a cikin fibromyalgia zai iya zama sakamakon mummunan aiki a cikin mitochondria (sassan jikinka wanda ya rushe kayan abinci don samar da makamashi.) Wani nazarin nazarin 2010 na kasar Spain, wanda aka buga a Clinical Rheumatology , ya nuna nauyin ƙwayoyin mast-wanda ya saki sinadarin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin cuta don amsawa ga magunguna daban-daban a cikin fata na mutane da fibromyalgia.
Yin maganin kumburi a Fibromyalgia
Tun da farko sunadaran maganin kumburi-steroid da NSAIDs-an riga an nuna su rashin amfani da ciwo na fibromyalgia, menene zabin da muke da shi don rage ƙanananmu kuma, da fatan sakamakon haka, zafi?
Wani bincike na shekara ta 2017 ya nuna cewa magani da ake kira naltrexone mai rauni (LDN) zai iya taimakawa wajen rage wasu alamomin kullun, wanda ya bayyana zai taimaka wajen rage ciwo da sauran cututtuka.
Nazarin nazarin 2010 a Liptan akan ƙananan ƙullun yana nuna cewa hanyoyin kwantar da hankulan da ke da alaƙa da fascia na iya zama tasiri. Wannan ya haɗa da suturar da aka siffanta ta (wanda aka warkar da shi ) da kuma abin da ake amfani dashi mai suna Rolfing. Duk da haka, ya zuwa yanzu, bincike akan waɗannan jiyya yana iyakance. Har ila yau, dangane da bayyanar cututtuka, wasu mutane da wannan yanayin bazai iya jure wa wasu nau'i na tausa ba.
Nazarin binciken da aka buga a Scandinavia 2012 ya nuna cewa motsa jiki na ruwa zai iya inganta daidaitattun cytokine a fibromyalgia, sabili da haka ƙananan matsi da zafi. (Kafin ka fara wani nau'i na motsa jiki, yana da mahimmanci a koyi game da hanyar da za a dace tare da fibromyalgia .)
Wasu mutane da fibromyalgia sun ce suna da sa'a da kari sunyi imani da ƙananan ƙonewa. Anti-mai kumburi kari sun hada da:
Har yanzu ba mu da bincike a game da cin hanci da rashawa ga fibromyalgia, amma likitocin da yawa sun ba da shawarar ga yanayin ƙullun. Saboda ba kowa ba ne na ƙwayar cutar ƙwayar cuta ɗaya, mutane sukan fara ne tare da rageccen abinci, sa'annan su sake dawowa a cikin irin abinci guda daya a lokaci don sanin wane abincin shine matsala.
Kalma daga
Yayin da muka koyi game da nauyin kumburi a cikin fibromyalgia, zamu iya gano sababbin sababbin magungunan kwayoyi da wasu jiyya, kuma hakan zai haifar da mafi kyawun maganin kulawa a hanya.
Ba mu san yadda muhimmancin kumburi yake ba, ko kuma yana da dalilin ko sakamakon yanayin. Wadannan tambayoyi ne da za a iya amsawa yayin da waɗannan bincike na ci gaba da bincike.
Sources :,
Backryd E, Tanum L, Lind AL, Larsson A, Gordh T. Journal of binciken bincike. > 2017 Mar 3; 10: 515-525. Doi: 10.2147 / JPR.S128508. Shaida na ciwon ƙwayoyin cuta da kuma ƙananan ƙwayoyin cuta a cikin marasa lafiya na fibromyalgia, kamar yadda aka tsara ta hanyar tsarin gina jiki mai yawan multiples wanda yake amfani da ruwan sanyi da kuma jini.
Blanco I, et al. Clinic rheumatology. 2010 Dec, 29 (12): 1403-12. Abubuwa masu mahimmanci na mastocytes a cikin fata biopsies na masu fibromyalgia marasa lafiya.
Bote ME, et al. Neuroimmunomodulation. 2012; 19 (6): 343-51. Inflammatory / danniya amsa dysregulation a cikin mata da fibromyalgia.
> Cordero MD, et al. Antioxidants & redox sigina. 2013 Mar 1; 18 (7): 800-7. Shin yana ƙone wani mummunan aiki a cikin fibromyalgia?
> Liptan, GL. Littafin jarida na aikin jiki da kuma hanyoyin kwantar da hankali. 2010 Jan, 14 (1): 3-12. Fascia: Hidimar da aka rasa a cikin fahimtar abubuwan da ke cikin fibromyalgia.