Arthritis Jiyya

An Bayyana Magungunan Arthritis

Magungunan maganin arthritis sun dade suna dauke da wani zaɓi na "gargajiya". Tun lokacin da mutum ya amsa tambayoyin kwayoyi zai iya bambanta kuma saboda tasiri mai tasiri da halayen halayen maɗaukaka kuma mahimmanci ne, gano magungunan maganin maganin ƙwaƙwalwar ƙwayar maganin ƙwaƙwalwar ƙwayar cuta zai iya zama tsari mafi wuya fiye da yadda za ku iya sa ran. Ya kamata ku zama masani game da magungunan maganin arthritis, don ku iya yin shawara tare da likitan ku.

NSAIDs / COX-2 Masu hanawa

Sassan NSAIDs (kwayoyin masu maganin magungunan cututtuka marasa lafiya) sune daga cikin kwayoyi masu amfani da cututtukan cututtuka. Akwai nau'o'i guda uku na NSAIDs: salicylates (duka acetylated [misali, aspirin] da wadanda ba a baza su ne ba [misali, Disalcid {Salsalate}]), Karfin (choline magnesium trisalicylate), da Doan ta kwayoyin cutar ko Novasal (salicylate magnesium); da al'adun gargajiya NSAIDs; da kuma COX-2 masu hanawa.

Hannun NSAID na aiki ta hanyar hana aikin enzyme, cyclooxygenase, wanda aka fi sani da COX. Bincike ya bayyana cewa akwai nau'i biyu na cyclooxygenase, wanda ake kira COX-1 da COX-2 . SAIGASI suna shafi duka siffofin biyu. COX-1 yana da hannu wajen rike nama mai lafiya, yayin da COX-2 yana cikin hanyar ƙonewa. COX-2 masu hamayya masu zabe sun zama asusun na NSAIDs-tare da Celebrex (celecoxib) wanda shine na farko da zai zama FDA-amincewa a ƙarshen shekarun 1990.

Harkokin gargajiya NSAID sun haɗa da:

COX-2 Masu hanawa sun hada da:

Karanta: NSAIDs - Abin da Ya Kamata Ku sani

DMARDs

DMARDs (cututtuka-maganin maganin cututtuka) ana kiran su "masu amfani da maganin anti-rheumatic" saboda suna yawan yin makonni ko watanni don aiki da kuma "layi na biyu". Bincike ya tabbatar da tasiri na DMARDs wajen maganin cututtukan arthritis , cututtuka na psoriatic , da kuma sparkylitis ankylosing da mahimmancin farkon, yin amfani da damuwa ta hanyar amfani da DMARDs. Manufar da ake bi da shi tare da DMARDs shine dakatar da ciwon cutar kuma ya dakatar da lalacewa.

DMARDs sun haɗa da:

Xeljanz (tofacitinib citrate), DMARD na baka, ya yarda da FDA a ranar 6 ga watan Nuwamba, 2012, don magance magoya bayan da aka yi aiki sosai ga magungunan wariyar launin fata wanda ke da rashin dacewar amsawa, ko rashin haƙuri, zuwa hanya. Xeljanz shine na farko a cikin wata kwayoyi da ake kira JAK (Janus kinase).

Karanta: Facts Game da DMARDs

Corticosteroids (Steroids)

Corticosteroids ko glucocorticoids, sau da yawa ake kira "steroids," suna da kwayoyi masu karfi wanda zai iya rage kumburi da ƙumburi da sauri. Wadannan kwayoyi suna da alaƙa da cortisol, wani hormone wanda ya haifar da kwaya daga cikin gland. An umarce su a cikin nau'i-nau'i daban-daban dabam dangane da yanayin da manufar magani. Yayin da za'a iya amfani da steroid don kare kumburi da abubuwan da ke cikin cututtukan cututtuka, irin su arthritis na rheumatoid, lupus , polymyalgia rheumatica , da kuma vascularitis , an ƙaddara cewa yiwuwar cututtuka mai tsanani ya ƙaru a manyan dogaye ko tare da dogon lokaci amfani.

Likitoci na iya yin bayani akan gajeren lokaci, magungunan steroid a cikin wasu lokuta, ko likitanku zai iya jagorancin allurar steroid a cikin wani takamaiman haɗin gwiwa, irin su Kenalog (triamcinolone), don taimaka maka samun taimako daga ciwo da kumburi.

Corticosteroids sun hada da:

Karanta: Corticosteroids (Steroids) - Abin da Ya Kamata Ku sani

Analgesics (Magunguna Magunguna)

Analysics ne maganin maganin ciwo. Yin maganin ciwo yana da muhimmanci wajen magance arthritis. Duk da haka, sabanin NSAIDs, magungunan kwakwalwa ba su taimaka kumburi ba. Acetaminophen (Tylenol) shine mafi yawan maganin analgesic. Magungunan kwayoyi na Narcotic na iya zama wajabta don ciwo mai tsanani.

Narcotics sun hada da:

Karanta: Magunguna na Analgesic - Abin da Ya Kamata Ya San

Maganin Halitta na Halittu (Biologics)

Ma'aikatan Gida na Halitta (BRMs), waɗanda aka fi sani da su kimiyyar halittu , daɗawa ko mayar da damar yin amfani da tsarin rigakafin don yaki da cutar ko kamuwa da cuta. Halittun halittu sune kwayoyi da aka samo daga asali masu rai kamar yadda ake shiryawa da sunadarai.

Enbrel (baitane) , Remicade infliximab) , Humira (adalimumab) , Cimzia (certolizumab pegol) , da kuma Simponi (golimumab) cibiyoyin TNF-alpha, daya daga cikin magungunan cytokine da suka fi muhimmanci a cikin cututtukan arthritis. Magunguna na TNF (kwayoyin halittu da ke ɗaure TNF-alpha) sun sa ya zama mai aiki, ta haka yana hana lalata ƙwayar cuta da kuma rage lalata haɗuwa.

Kineret (anakinra), magungunan kwayar halittu ne, wani mai maganin IL-1 ne. Kineret shi ne mai farko da aka zaba na interleukin-1 (IL-1), wani sinadaran da aka samu a cikin wasu mutane tare da maganin ƙwayar cuta. Ta hanyar kulle IL-1, Kineret ya hana kumburi da zafi da ke hade da maganin arthritis na rheumatoid. Kineret za a iya amfani da shi kadai, ko a haɗa tare da wasu DMARDs, sai dai magungunan TNF. Duk da yake Kineret wani zaɓi ne, yana da wuya an tsara shi.

Orencia (abatacept) ita ce ta farko ta T-cell co-stimulation modulator da za a yarda domin maganin rheumatoid arthritis.

Rituxan (rituximab) , mafi yawan sayen magani na duniya, wanda aka amince da shi a watan Maris na shekara ta 2006 don amfani dasu tare da bin hanyoyin maganin cututtuka na rheumatoid ta hanyar rage alamomi da alamun bayyanar cutar a cikin tsofaffi waɗanda ke da cututtuka na rheumatoid mai tsaka-tsakin gaske. ya kasa ɗaya ko fiye da magungunan TNF. Rituxan shine maganin farko na cututtukan maganin rheumatoid wanda ke sa ido ga sassan kwayoyin B-B-2.

Actemra (tocilizumab) wani ɓangare na daya ne wanda ke hana mai karɓa na interleukin-6 (IL-6), don haka ya hana interleukin-6. Dokar ta FDA ta amince da dokar ta ranar 8 ga watan Janairu na 2010 domin maganin cutar wariyar launin fata a cikin mutanen da suka kasa daya ko fiye da masu jefa kuri'ar TNF.

Rheumatoid Arthritis Jiyya - ACR shawarwarin

Fibromyalgia Drugs

Har zuwa shekara ta 2007, babu wata kwayoyi da FDA ta amince don maganin fibromyalgia . Doctors bi da fibromyalgia tare da iri-iri kwayoyi ci gaba da yarda ga wasu alamomi. A 2007, an yarda da Lyrica (pregabalin) don magance fibromyalgia. A shekara ta 2008, an amince da Cymbalta (duloxetine HCl) don fibromyalgia. A shekara ta 2009, an amince da Savella (HCl milnacipran) don yanayin.

Gout Drugs

Gout yana daya daga cikin siffofin cututtukan da ke fama da ciwo na cututtuka. Ana iya sarrafa shi tare da magani, abinci, da canje-canje na rayuwa. Akwai bangarori uku na gout magani tare da magani: analgesics, anti-inflammatory magunguna, da kuma kwayoyi don gudanar da tsarin uric acid da hare-haren gout .

Drugs for gout sun hada da:

Osteoporosis Drugs

Osteoporosis yanayin ne wanda ke da alamar raguwa da ƙananan kasuwa, wanda ya fi dacewa da tsofaffi, amma kuma yana iya zama matsala ga mutanen da suka dauki corticosteroids (steroids) tsawon lokaci. Akwai nau'o'i da yawa na zafin miyagun ƙwayoyi don osteoporosis: isrogens, hormones na parathyroid, wakili na kashi kashi, bisphosphonates, da kwayoyin masu karɓa. Dangane da abin da aka yi amfani da miyagun ƙwayoyi, zaka iya rage hasara na kasuwa, inganta ci gaban kashi, da rage haɗarin ɓarna.

Drugs for osteoporosis sun hada da:

Kalma Daga

Makasudin manufar maganin arthritis da cututtukan rheumatic tare da magani sun hada da maganin ciwo, rage yawan ƙumburi, jinkirin cigaba da cutar, da kuma kula da ayyukan cutar. Akwai magungunan ƙwayoyi da dama da yawa a kowane nau'in magani. Wannan ya sa zaɓar wani magani tsarin mulki da ɗan rikitarwa. Yanke abin da magani ko haɗin magunguna ya dace don ku iya zama damuwa. Wataƙila za a yi gwaji da kuskure-kuma za ku ci gaba da ƙoƙari har sai kun ji cewa kun sami cikakkiyar amsa. Verywell ya tattara ainihin gaskiyar da kake bukatar sanin game da magungunan arthritis. Bayanin da aka bayar zai taimake ka ka fahimci dalilin da yasa kake shan magani kake ɗauka kuma zai taimake ka ka tsara tambayoyi ga likitanka.

> Source:

> Kelley's Textbook na Rheumatology. Sashe na 8. Pharmacology of Antirheumatic Drugs. Elsevier. Tsarin na tara. Samun shiga 07/23/16.

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