SAISU suna daga cikin kwayar cututtukan cututtukan cututtuka
Hannun NSAID (masu maganin maganin ƙwayoyin cuta ba tare da maganin kumburi ba) suna fama da maganin arthritis ta hanyar tsangwama tare da tsarin kumburi. Hannun su ne babban ɓangaren magungunan da ake amfani dasu don magance cututtukan zuciya saboda sun:
- analgesic (ciwo-kashe) Properties
- anti-inflammatory Properties
- antipyretic (ciwon zazzabi)
NSAID Categories
Akwai NSAIDs guda uku:
- salicylates (duka acetylated, kamar aspirin , da noncetylated)
- gargajiya NSAIDs
- COX-2 masu hanawa
ABIN da aka saba amfani da su don maganin arthritis sun hada da:
- Ansaid (sunan mahaifa flurbiprofen)
- Arthrotec (sunan mahaifa diclofenac tare da misoprostol)
- Aspirin (acetylsalicylic acid)
- Cataflam (jinsin sunan diclofenac potassium)
- Celebrex (sunan mahaifa celecoxib)
- Clinilil (sunan mahaifa sulindac)
- Daypro (jinsin sunan oxaprozin)
- Disalcid (sunan salsalate na jigilar jini)
- Dolobid (sunan jigilar sunan jabu)
- Feldene (sunan mahaifa piroxicam)
- Ibuprofen (sunayen sun hada da Motrin, Advil, Mediprin, Nuprin, Motrin IB)
- Indocin (sunan jinsin sunan indomethacin)
- Ketoprofen (sunaye sun hada da Orudis, Oruvail, Actron, Orudis KT)
- Lodine (sunan mahaifa etodolac)
- Meclomen (sunan mahaifa meclofenamate sodium)
- Mobic (sunan jinsin mai suna)
- Nalfon (Generic sunan fenoprofen)
- Naproxen (sunayen sun hada da Naprosyn, Aleve, Naprelan, Anaprox)
- Ponstel (sunan jinsin sunan mefenamic acid)
- Relafen (jigilar sunan nabumetone)
- Zaɓi (sunan jinsin tolmetin sodium)
- Farfesa (sunan jinsin sunan choline magnesium trisalicylate)
- Tsarin (sunan mahaifa diclofenac sodium)
Ta yaya NSAIDs aiki
A cikin sauƙi, Ma'aikatan NSAID suna aiki ta hanyar rage kumburi. Suna yin haka ta hanyar hana wani ƙulli na ƙashin ƙonewa da ake kira cyclooxygenase, wanda ya canza dabi'ar acid acid ga prostaglandins da leukotrienes.
Prostaglandins suna sa ƙonewa na gida. Saboda haka, ta hanyar hana cyclooxygenase, NSAID din rage ƙonewa .
Wani NSAID na musamman zai iya aiki mafi alheri a gare ku fiye da wanda kuka yi kokarin kafin - ko kuma bazai aiki ba tukuna. Wannan shi ne saboda wani abu da ake magana da shi azaman bambance-bambancen pharmacokinetic - tsarin da ake amfani da kwayoyi, rarraba, gyare-gyaren, da kuma kawar da shi.
Karin bayani a kan Enzyme Cyclooxygenase
Akwai nau'i biyu na cyclooxygenase, wanda ake kira COX-1 da COX-2. COX-1 yana da hannu wajen riƙe da ciki da koda. COX-2 shine enzyme da alhakin kumburi. Saboda al'ada NSAIDs toshe COX-1 da COX-2, zasu iya samun sakamako mai lalacewa maras so, irin su ciwon ciki ko rage aikin koda. Wannan shine dalilin da ya sa masu bincike suka kirkiri NSAIDS wanda kawai ke hana COX-2. Wadannan masu haɓaka masu zaɓi COX-2 sune sabuwar ƙungiyar NSAIDs.
Aikace-aikacen FDA ga dukan NSAIDs
A shekara ta 2004, mai sana'a na COX-2 mai hana maye gurbin Vioxx ya janye shi daga kasuwa bayan binciken ya nuna amfani da dogon lokaci zai iya ƙara haɗarin zuciya da bugun jini. Binciken na gaba da Cibiyar Abinci da Druggun Amurka ta kai ga 2005 da ake bukata cewa duk wadanda basu da aspirin NSAID suna daukar gargaɗin da ya shafi hakan.
Yana da mahimmanci don tattauna irin wannan hadarin da likitan ku. (Bayan bayanan ya bar maƙallacin COX-2 kawai a kasuwa - Celebrex.)
Amfanin NSAIDs
- Saurin rai da kuma kumburi wani lokaci yakan faru a cikin wani circadian rhythm (yau da kullum rhythmic sake zagayowar dangane da awa 24 hours). Saboda haka, NSAIDs zai iya zama mafi tasiri a wasu lokuta.
- Kimanin kashi 60% na marasa lafiya zasu amsa wa NSAID guda ɗaya. Wata fitina na makonni uku ya kamata ya ba ka lokaci mai yawa don sanin idan magani yana aiki a gare ku. Abin takaici, kimanin kashi 10 cikin dari na marasa lafiya na wutsiya marasa lafiya za su sami NSAID ba sa aiki a gare su.
- Hannun NSAID zasu iya rufe alamomi da alamun bayyanar cutar.
- Abubuwa masu banƙyama na NSAIDs wanda zasu iya faruwa a kowane lokaci sun hada da gazawar koda, ciwon hanta, zub da jini, da kuma ciki (ciki) ulceration.
- HAUSA (musamman indomethacin) zai iya tsoma baki tare da magungunan da ake amfani dasu wajen sarrafa karfin jini da nakasawa na zuciya (kamar beta-adrenergic antagonists, angiotensin-converting enzyme inhibitors, or diuretics).
- Wasu nazarin binciken da aka yi amfani da shi na tsawon lokacin da aka yi amfani da NSAID zai iya gaggauta haɗari ga asarar mota, amma ana bukatar karin bincike.
Layin Ƙasa
Ba za a iya hango abin da NSAID zai fi dacewa ba. Babu wani NSAID daya da aka tabbatar ya zama mafi girma a kan wasu don taimakon jin zafi. Da zarar aka zaɓa NSAID, za a kara sashi a lokacin da aka sauya zafi ko kuma har sai an sami iyakar matsakaicin magani. Amsar mai haƙuri zai zama jagora don zaɓin kashi mai kyau, ta yin amfani da mafi ƙanƙanci na kasuwa don samun taimako na jin zafi. Yi bayani kullum game da amfani da hadarin da suka shafi NSAID tare da likitan ku.
> Sources:
> Cibiyar Nazarin Arthritis ta Jami'ar Duke, David S. Pisetsky, MD, Ph.D. 1995.
> New England Journal of Medicine, 324 (24): 1716-1725, 1991