Na farko TNF Blocker ya amince da Arthritis Rheumatoid a shekarar 1998
Enbrel (tsinkayyar) wani haɓakaccen bayani ne na halitta (wani mutum mai soluble mai cike da ƙwayoyin necrosis factor receptor fusion protein). Enbrel an tsara shi ne a cikin jiki don zama kamar masu karɓar jiki a jikin da ke ɗaukar nau'in ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin cutar (TNF-alpha). Enbrel yana aiki ne ta hanyar daukar nauyin TNF gaba daya kafin ya iya haɗawa ga masu karɓar halitta.
TNF-alpha shi ne cytokine da ke cikin tsarin mai kumburi.
Tsaro TNF-alpha an hade shi da cututtukan arthritis da sauran siffofin cututtuka na jini .
Kayan maganin likitoci
Enbrel shine magunguna na farko na TNF kuma an yarda da ita a shekarar 1998 don cutar arthritis da kuma wasu cututtukan cututtuka. Remicade (infliximab) shi ne na biyu mai sarrafawa na TNF da Cibiyar Abinci da Drug ta Amurka ta ba da izini a 1999. An amince da Humira (adalimumab) a 2002. FDA ta amince da Simponi (golimumab) a ranar 24 ga watan Afrilun 2009. Cimzia (certolizumab pegol) ) An amince da FDA a ranar 14 ga Mayu, 2009.
An samo Enbrel ta hanyar gabatar da DNA ta mutum a cikin jikin kwayoyin halittar hamster na kasar Sin da kuma samar da furotin da aka haɓaka a cikin halittar. Remicade yana amfani da sunadarai na mutum da na linzamin kwayoyi don ƙirƙirar wani mutum mai yarinya na kodimir. Humira yana amfani da dukkanin sunadarai na mutum da fasaha na phage don samar da kwayoyin halitta guda daya.
Gudanarwa
Ana aiwatar da Enbrel a matsayin injection subcutaneous sau ɗaya ko sau biyu a kowane mako (kwanaki 3 ko 4).
Dokar wajabta ya dogara ne akan yanayin da ake bi. Dole ne likitanku ya umarce ku da ƙwararriyarku kuma yana buƙatar izinin inshora. Enbrel za a iya amfani da shi a hade tare da methotrexate a cikin marasa lafiya waɗanda ba su amsa methotrexate kadai.
Dokar
An yarda da Enbrel don magance matsakaicin matsananciyar cututtuka na jini, matsananciyar matsananciyar cututtukan zuciya mai cututtuka , cututtuka na psoriatic , ƙananan spondylitis , matsananciyar matsakaicin matsakaicin matsakaici na psoriasis.
Amfanin da aka yarda
Ga tsofaffi da cututtuka na rheumatoid, rubutun cututtuka na psoriatic, da kuma sparkylitis ankylosing, kashi na saba'in na Enbrel na da 50 MG a kowane mako da ake gudanarwa a matsayin magungunan subcutaneous ta yin amfani da sirinji na 50-mg / ml guda daya. Akwai nau'i na 25 MG na Enbrel wanda ma akwai.
Jigon Enbrel da aka ba da umurni ga ƙwayar ciwon ƙwayar ƙananan yara ya dogara ne akan nauyin yaron. Zaɓin dosing a mako guda yana samuwa ga yara suna kimanin 138 lbs ko fiye. Domin psoriasis , nauyin da ake amfani dashi shine 50 MG sau biyu a mako don watanni 3, ya sauka har sau ɗaya a mako.
Ra'ayoyin Musamman
Enbrel ba a ba da shawara ga mata masu ciki ko masu hayarwa ba. Ba za a bi da marasa lafiya da ciwo mai tsanani ba tare da Enbrel. Mutane suna fama da kamuwa da cuta ko wadanda ke da ciwon sukari marasa amfani suyi amfani da Enbrel. Marasa lafiya tare da wasu sharuɗɗan tsarin kulawa na tsakiya ya kamata ya kauce wa Enbrel.
Hanyoyin Kasuwanci
Abubuwan da suka shafi lalacewar da aka haɗa tare da Enbrel sun hada da:
- injejin halayen shafin
- cututtuka na numfashi na sama, ciki har da cututtuka na sinus
- ciwon kai
- dizziness
- hancin hanci
- makogwaro fushi
Muhawara Mai Kyau
Enbrel zai iya ƙara haɗarin cututtuka mai tsanani. A cikin mutanen da aka bi da su tare da Enbrel, akwai rahotanni na sclerosis da yawa, maganin ƙwaƙwalwar ƙwayar ƙwayar ƙwayar ƙwayar cuta , da ƙananan ƙwayar cuta (ƙin ciwon ƙwayar jijiya), da kuma pancytopenia (ƙananan ƙwayoyin sel, sel fararen, plalets).
Storage
Ya kamata a adana Enbrel a zafin jiki na 36 zuwa 46 digiri Fahrenheit. Duk da haka, ana iya kiyaye Enbrel a dakin zafin jiki har zuwa kwanaki 14. Kada a adana Enbrel a cikin daskarewa.
A cewar enbrel.com, idan ya yi tafiya fiye da 'yan sa'o'i, ya kamata ka kunna Enbrel a cikin kumfa da kunsa kuma sanya shi a cikin mai sanyaya mai kwakwalwa tare da kankara. Ƙara thermometer zuwa mai sanyaya kuma duba shi kowane 'yan sa'o'i. Za ka iya samun mai kula da kayan tafiye-tafiye kyauta da kankara don Enbrel ta kiran Ƙarfin Enbrel a 1-888-4ENBREL. Idan tafiya ta iska, bincika jirgin sama don bukatunsu.
Sources:
Arthritis Without Pain, Scott J. Zashin, MD, An wallafa ta Sarah Allison Publishing Company.
Enbrel - Littafin Tsira, Fitowa na 10
Jagoran Magunguna. Enbrel.com. Revised 11/2013. http://pi.amgen.com/united_states/enbrel/derm/enbrel_mg.pdf
Bayyana Bayani. Enbrel.com. Revised 03/2015. http://pi.amgen.com/united_states/enbrel/derm/enbrel_pi.pdf