Cimzia wani mai amfani ne na TNF wanda aka yi amfani da shi don ƙwayar cututtuka
Cimzia (certolizumab pegol) shine TNF (kututture necrosis factor) mai kwakwalwa- wannan magungunan magani kamar Enbrel (Etanercept) , Remicade (infliximab) , Humira (adalimumab) , da Simponi (golimumab). Cimzia ne kawai magani a cikin TNF ajiya cewa touts kasancewa ƙasa da guba ga kwayoyin saboda abubuwan da sunadaran sunadarai (misali, PEGylated, Fc yankin free). Bugu da ƙari, idan aka kwatanta da wasu masu safarar TNF, Cimzia ya ruwaito cewa yana da dangantaka mafi girma ga TNF.
Mene ne TNF?
Yana taimaka wajen sanin abin da TNF yake don haka zaka iya fahimtar dalilin da yasa Cimzia ke aiki don toshe shi. TNF ita ce cytokine , musamman mawakan kwayoyin tsakanin kwayoyin halitta, wanda ke taka muhimmiyar rawa a cikin tsari mai kumburi . An samar da aikin TNF-alpha mai wucewa ta jikin jiki zuwa wasu cututtuka da yanayin, ciki har da arthritis na rheumatoid .
Ta yaya aka ba Cimzia?
Cimzia an allura karkashin fata. An bayar da shi azaman foda wanda dole ne a sake gina shi cikin tsarin ruwa don haka za'a iya ba shi a matsayin injection subcutaneous.
Mahalarta, UCB, Inc., ta bayyana cewa abubuwan da ke da ƙwayoyin magungunan Cimzia na iya sanya shi mafi kyawun zaɓi fiye da masu tarin magungunan TNF na yanzu don marasa lafiya na cututtuka. Ta kayan shafa zai iya rage halayen halayen haɗarin da ke dauke da allura da kuma maganin miyagun ƙwayoyi zuwa wuraren kumburi na iya ingantawa, yana buƙatar kasawan dosage fiye da sauran injectables.
Bayan ƙaddamarwa na farko, akwai tsari mai tsabta.
Cimzia za a iya ba a cikin lokaci na makonni biyu ko hudu - ko dai shi kadai ko tare da hanya.
Ayyukan Cimzia a cikin gwaji na Clinical
An samo rahoton Cimzia na gwajin gwaji mai kyau. Sakamakon binciken na biyu na III ya nuna amfanci mai amfani lokacin da ake amfani da Cimzia kadai ko a hade tare da matakan da ke cikin tsofaffi tare da ciwon maganin ƙwayar cuta (watau synovitis ).
Musamman, bincike na mako-mako FAST4WARD ya nuna cewa 400 Mm na Cimzia, an ba kowane mako hudu a ƙarƙashin hanya, ya rage rage ciwo da alamu da bayyanar cututtuka na arthritis na rheumatoid da ingantaccen aikin jiki idan aka kwatanta da waɗanda suke a kan placebo.
Nazarin RAPID ya bayyana cewa amfanin amfani da Cimzia tare da methotrexate. RAPID1 ya nuna amfanar lokaci mai tsawo a amfani da Cimzia dangane da alamar taimako, inganta yawan aiki da ingancin rayuwa, da kuma rage gajiya. Wani binciken na RAPID na biyu, wanda aka sani da RAPID2, ya nuna cewa Cimzia tare da methotrexate sun inganta alamomi da bayyanar cututtuka na cututtuka na rheumatoid, sun hana ci gaba da cutar, da kuma inganta aikin jiki a marasa lafiya da cututtuka masu ciwon zuciya.
Cimzia Side Effects
Abubuwa masu tasiri masu tsanani sun samo asali a wasu mutane suna shan Cimzia. Bayanan da aka bayar game da Cimzia yayi kashedin game da:
- Babban cututtuka, ciki har da tarin fuka
- Ciwon daji, ciki har da lymphoma
- Matsalar matsaloli, ciki har da sclerosis da yawa
- Allergic halayen
- Cutar jini
- Sabo ko rashin ciwo zuciya
- Hanyoyin motsa jiki, ciki har da ciwo na lupus-like
Hanyoyin da ke hade da Cimzia sune cututtuka na sama, cututtuka na urinary, ciwon haɗin gwiwa, da halayen shafin yanar gizon.
Shin Cimzia FDA-Tabbas?
A ranar 22 ga watan Afrilu, 2008, Cimzia shi ne FDA-an amince da shi don kula da matsakaici zuwa cutar mai tsanani na Crohn a cikin tsofaffi waɗanda ba a taɓa taimakonsu ba saboda sababbin jiyya. Ranar 14 ga watan Mayu, 2009, FDA ta amince da Cimzia don magance marasa lafiya marasa lafiya da ke da matsananciyar ciwon zuciya. Ana kuma ƙididdige magunguna don cututtukan cututtuka na psoriatic da sparkylitis ankylosing .
Cimzia yana samuwa a cikin wani sirinji wanda ya cika da ya cika wanda ke dauke da Amfanin Arthritis Foundation na Amfani da Amfani. Tsarin sirinji shine sakamakon haɗin gwiwa tsakanin UCB da OXO (wanda aka fi sani da su na kayan aiki na kayan wuta da sauran kayan aikin mai amfani).
Sources:
Cimzia. Cikakken Bayanan Bayani. UCB. Revised Afrilu 2016.
http://www.cimzia.com/assets/pdf/Prescribing_Information.pdf
Cimzia. Jagoran Magunguna. UCB, Inc. An sake fasalin Afrilu 2016.
http://www.cimzia.com/assets/pdf/MedicationGuide.pdf