Da zarar Gwargwadon Kula da Lafiya na Rheumatoid Arthritis
A baya, magungunan zinariya shine ma'auni na musamman don matsakaicin aiki sosai. Ana amfani da mahadi na zinariya don magance cututtuka na rheumatoid tun 1929. An gina zinari a matsayin magani ga tarin fuka. A wancan lokacin, an yi kuskuren zaton cewa cutar tarin fuka da kuma cututtuka na rheumatoid sune yanayi ne. Yayinda wannan ya zama kuskure, zinari bai nuna sakamako mai amfani akan rheumatoid arthritis ba.
Yadda Yake aiki
Duk da yake ba a fahimci ma'anar zane-zane na ƙananan zinari ba, shaida ta nuna cewa an adana zinari a cikin lysosomes inda hakan ya hana aiki na magungunan antigenic (duk wani abu wanda ya haifar da samar da kwayoyin cutar) da kuma sakin cytokines masu cin hanci . Saboda haka an classified shi azaman maganin ƙwayar cutar anti-rheumatic (DMARD) .
Akwai Zinariya
Ana yin allurar nau'i na zinariya ne kuma sun hada da Myoschrysine (aurothiomalate) da Solganol (aurothioglucose). Ridaura (auranofin) ita ce farfadowa na zinariya. A tsawon shekaru, yayin da sababbin jiyya suka samo asali wanda ya ba da kyauta mai mahimmanci da kuma rashin haɗari (misali, wasu DMARDs da kwayoyin halittu ), ƙananan ƙwayoyin zinari sun saba wa ka'idar maganin ƙwayar cuta. Amfani da shi ya raguwa da farko saboda hadarin illa mai lalacewa, kazalika da buƙatar kusa da ɗakunan shan magani da kuma saka idanu, da kuma rashin jin daɗin ciwon intramuscular.
Ta yaya aka sarrafa Zinariya?
An yi amfani da hotuna na zinariya a matsayin ginin intramuscular a ofishin likita a mako guda na farkon makonni 20 na jiyya sannan kuma an rufe mita zuwa kowane mako uku ko hudu. An gwada gwajin jini da gwajin gwajin gaggawa kafin kowane allurar zinariya, don tabbatar da cewa yana da lafiya ya ba.
Da farko, an yi amfani da allurar zinariya na intramuscular a matsayin karamin nau'i 10-digigram, sau ɗaya a mako. Sakamakon kashi ashirin da biyar na miliyoyin nau'in ya biyo baya sannan kuma 50 milligrams a mako har sai an sami amsa, har zuwa kimanin 750 zuwa 1000 milligrams.
Hanyoyi na gefen Yarda Kayan Gida na Farko
Sakamakon sakamako, dalilin da ya fi dacewa da dakatar da farfadowa na zinariya, ya shafi kimanin kashi 30 cikin dari na mutanen da aka haifa da mahaifa na mahaifa. Hanyoyin da ke hade da iyayensu sun hada da pruritis, dermatitis, stomatitis, da proteinuria. Tare da zane mai launin zinare, suturar lalacewa tana da tasiri, yayin da cututtukan ruwa ya faru sau da yawa (shafi har zuwa kashi 5 na marasa lafiya). Namiphathy da thrombocytopenia kuma zasu iya inganta tare da farfadowa na zinariya, musamman a cikin wadanda suke da kyau ga mahalar HLA-DR3.
Duk da yake akwai tasirin da ya shafi tasirin cutar, ya kamata a lura cewa injections na zinariya sun sanya wasu mutane tare da ciwon gurasar ƙwayar cuta a cikin wanzuwa. Masanin ilimin rheumatologist Scott J. Zashin, MD ya yi sharhi, "A sakamakon haka, idan mai haƙuri ya sami kyakkyawar amsa ga inganci na zinariya, ana ci gaba da ci gaba. Tsayawa da zinariya a cikin wadannan marasa lafiya na iya haifar da sake dawowa da aikin arthritis wanda ba zai iya amsawa ba. sake dawowa da farfado da zinariya. "
Duk da haka, kamar yadda aka yi amfani da launin zinari a cikin ƙasa kuma a yayin da aka fara sababbin jiyya, kamfanonin sun dakatar da yin magani. Duk da yake akwai siffofin zinare biyu a lokaci guda (Solganol da Myochrysine), kawai Myochrysine yana samuwa yanzu. Sau da yawa, marasa lafiya suna ci gaba da karɓuwa a gare su, suna yin katsewa ya zama dole.
Zinariya Maganin Da aka kwatanta da Zinariya Injectable
Abin baƙin ciki shine, zane-zane mai launin fata ne kawai ya haifar da ƙananan sakamako, don haka ba'a saba wa doka ba. Ridaura, shirye-shirye na kwakwalwa na yau da kullum, yana iya samuwa, amma an yi amfani da ita a Amurka. An nuna zinariyar zane mai kyau idan aka kwatanta da placebo.
An dauke shi sosai tasiri ga Plaquenil (hydroxychloroquine) da kuma methotrexate , amma tare da mafi girma yiwuwar maye.
Layin Ƙasa
Zinari shine DMARD magungunan (maganin cututtuka masu maganin cutar) wanda yake a cikin dukkanin lokuta, an maye gurbinsu da sababbin DMARDs da kwayoyin halitta. An yi amfani da zinariya da yawa don marasa lafiya waɗanda ba su amsa ko basu iya jurewa hanya ba, wasu tsohuwar DMARDs (irin su Plaquenil da sulfasalazine ), ko kuma masu tarin TNF .
Sources:
> Cush JJ, Weinblatt ME, Kavanaugh A. Rheumatoid arthritis: farkon ganewar asali da magani . West Islip, NY: Sadarwar Kasuwancin; 2010.
> Klinkhoff A. Babban mawuyacin sakamako na farfadowa na zinariya. Na zamani. https://www.uptodate.com/contents/major-side-effects-of-gold-therapy.
> Klinkhoff A. Amfani da Ƙananan Magunguna a Cututtukan Rheumatic. Na zamani. https://www.uptodate.com/contents/use-of-gold-compounds-in-rheumatic-diseases?source=see_link.