Ganin haɗari da sharuddan kulawa
Orencia (abatacept) wata kwayar halitta ne da aka yarda don maganin matsakaicin matsananciyar cututtuka na rheumatoid . An kuma amfani dasu don biyan cututtuka na psoriatic da matsakaici zuwa ƙananan ƙwayar cutar ƙwararrun ƙananan yara .
Orencia ba mai tsaro ne na TNF kamar Enbrel ba (Human) ko Humira (adalimumab) wanda ake amfani da sinadaran ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin ƙwayoyin cuta (TNF).
Maimakon haka, Orencia yayi aiki ta wajen hana sinadarin sunadarai da ke haifar da kai harin.
Jiyya yana samuwa a cikin nau'i biyu:
- Orencia za a iya tsĩrar da shi a cikin jita-jita guda hudu (IV) a kowane makonni hudu bayan an fara aiki na farko (kashi na farko, kashi na biyu a makonni biyu, da kuma allurai kowane mako hudu).
- Orencia ma yana samuwa a cikin tsari mai sassaukarwa wanda ya ba mutane damar ba su harbi a ko dai cinya, ciki ko babba. Jiyya yakan fara ne da wani nau'i mai nauyin jigilar IV wanda ya biyo baya a wata rana daga baya. Ana yin gudanarwa a cikin mako-mako.
Duk da yake Orencia zai iya raguwar lalacewar haɗin gwiwa da rage cututtukan arthritic, yana da muhimmanci mu fahimci yadda miyagun ƙwayoyi ke aiki, idan an umarce shi, da kuma abin da, idan akwai, ana haɗari haɗari da amfani. Ga waɗannan abubuwa biyar da zasu taimaka:
1. An rubuta Orencia Bayanan Sauran Ƙunƙasa Ba a Yi nasarar ba
Ana amfani da Orencia sau da yawa a cikin mutanen da ke fama da matsananciyar cututtuka wanda ba su amsa daya ko fiye da maganin cututtukan antirheumatic ( DMARDs ) irin su methotrexate ko wasu kwayoyin halitta kamar Enbrel ko Humira.
Za a iya amfani da abatacept kawai ko a hade tare da DMARDs, wanda ya sa ya fi ƙarfin, amma ba tare da wasu kwayoyin halitta ba. Orencia za a iya la'akari da farfadowa na farko a cikin mutanen da ke fama da cutar arthritis.
2. Orencia Tayi aiki ta Ƙarfafa tsarin bazawar
Magungunan kwayoyin da ake amfani dasu don magance cututtuka na rheumatoid yana nufin hana rigakafi daga mummunar kayan kansa, musamman wadanda suke haɗin gwiwa.
Don yin wannan, kwayoyi suna buƙatar rufe ɓangarori na amsawa na rigakafi. Yin haka, ya bar jikin ya buɗe zuwa cututtuka zai iya yin yaki. Mafi yawan waɗannan sun haɗa da cututtuka na numfashi (ciki har da ciwon huhu), kwakwalwa na fata guda bakwai, fata da laushi mai laushi, da kuma cututtuka na urinary.
Duk da haka, yawan binciken da aka nuna sun nuna cewa Orencia yana haɗuwa da mummunar haɗari da ƙwayar cuta mai tsanani da kuma asibiti idan aka kwatanta da Enbrel, Rituxan (rituximab), da Actemra (tocilizumab).
3. Mutane a kan Orencia suna Rashin Ƙari na Tarin fuka
Babban cikin damuwa shi ne hadarin tarin fuka (TB), musamman maimaita TB a cikin mutanen da suka kamu da cutar. Bincike ya nuna cewa mutanen da aka fallasa su a Orencia suna da karuwar sau hudu a cikin hadarin irin wannan sakewa.
Kafin fara magani, dole ne a yi wa mutane ƙwaƙwalwa don TB. Dole ne a samu nasarar magance mutanen da ke fama da ƙwayar cutar TB kafin a iya amfani da miyagun kwayoyi.
4. Mutane a kan Orencia Dole ne su guje wa kwayoyin cutar yayin da suke jiyya
Sauran maganin alurar rigakafin rayuwa sune wadanda ke dauke da kwayoyin rai, raunana ƙwayoyin cuta (kamar yadda ya saba da maganin alurar rigakafi wanda aka kashe "ƙwayoyin").
Saboda Orencia ya raunana tsaro na mutum, akwai wata dama cewa maganin alurar rigakafi zai iya haifar da cutar da ya ke so ya hana.
Saboda haka, ana gargadin mutanen kan Orencia don kaucewa maganin alurar riga kafi kafin fara magani, a lokacin magani, da kuma watanni uku bayan kammala magani. Wadannan sun haɗa da:
- Nasarar mura daga nasal ( FluMist )
- Shingles alurar riga kafi
- Varicella (chickenpox) alurar riga kafi
- Muddin-mumps-rubella (MMR) maganin alurar riga kafi
- Rotavirus maganin alurar riga kafi
- Yaduwar cutar zazzabi
- Typhoid
5. Orencia ya kamata a yi amfani da shi tare da hankali a cikin mutane tare da COPD
A cikin gwaji na asibiti, mutanen da ke fama da cututtuka na huhu ( COPD ) sun sami ci gaba mai tsanani na COPD yayin da ke Orencia, ciki har da tari mai tsauri, rashin ƙarfin numfashi, da kuma raguwa.
Saboda wannan dalili, Orencia ya kamata a yi amfani da hankali tare da mutanen da ke tare da COPD, suna la'akari da amfani da sakamakon sakamakon. Bugu da ƙari, ya kamata a ba da kulawa mafi girma ga kulawa da mutane tare da COPD a yayin bayyanar cututtuka na numfashi. A irin wannan hali, magani na iya buƙatar tsayawa.
> Sources:
> De Keyser, F. "Zaɓin Harkokin Halitta na Halitta ga marasa lafiya da cututtukan Arthritis Rheumatoid: Hasashen Bincike." Curr Rheumatol Rev. 2011; 7 (1): 77-87. DOI: 10.2174 / 157339711794474620.
> Yun, F .; Xie, F .; Delzell, E. et al. "Rashin kwatantaccen kamuwa da cututtuka na asibiti da aka hade da ma'aikatan ilimin halittu a Rheumatoid Arthritis Patients Shiga a Medicare." Arthritis & Rheumatology . 2015; 68: 56-66. DOI: 10.1002 / art.39399.