Shin maganin cututtukan maganin cututtuka ne ya dace don cututtukan Arthritis Rheumatoid?
Tarihin Bincike don Dalili da Cure
Ba tare da wani magani da aka sani ba game da irin maganin arthritis fiye da 100, magancewa da kuma shan wuya tare da bayyanar cututtuka sun zama mahimmancin damuwa ga marasa lafiya da likitoci. A cikin shekarun 1930, an yi bincike akan kwayar cutar kwayar cuta, amma bincike bai wanzuwa ba sai dai ga wasu lokuta na cututtuka masu cutar ko magunguna .
A 1939, ainihin ainihin gubar game da cututtukan cututtuka na cututtuka na rheumatoid ya tashi a lokacin da mycoplasma, irin kwayoyin cututtuka masu kama da kwayar halitta, aka ware daga wariyar launin fata da nama na marasa lafiya na rheumatic. Masu binciken sun riga sun nuna cewa mycoplasmas na haifar da cututtuka a cikin ƙuda, berayen, kaji, awaki, da shanu. Sun sami mycoplasmas a cikin sassan dabbobi na dabbobi, musamman mata.
A shekara ta 1949 a Majalisar Dinkin Duniya a kan cututtuka na Rheumatic, an bayar da rahoton yiwuwar dangantaka tsakanin mycoplasmas da kuma hadin gwiwa. Bayan da ya sami daya daga cikin binciken farko na NIG a cikin 1950, Thomas McPherson Brown, da kuma abokan aikinsa a cibiyar binciken bincike na arthritis sun ruwaito cewa shekara ta gaba da cewa cutar rashin lafiya ta kamu da kwayar cutar kwayar cutar ta kwayoyin cuta (antigen and antibody) tare da mycoplasma kamar yadda ake zaton antigen) maimakon nau'in cututtuka da mawuyacin hali.
A shekara ta 1955, ƙungiyar bincike ta nuna cewa mycoplasmas, ba kamar kwayoyin cuta da ƙwayoyin cuta ba zasu iya rayuwa a cikin al'adun halitta ba tare da lalata kwayoyin halitta ba. Don ci gaba da tallafawa mycoplasmas a matsayin mai maye gurbin / antigen, a 1964 an sami mummunar tasiri na kwayoyin cuta na mycoplasma a cikin jinin marasa lafiya na cututtukan zuciya da kuma marasa lafiya Lupus , yana nuna halin yanzu ko kamuwa da cuta ta baya.
Har ila yau, an gane cewa kamu 4 da 1 ne mafi girma daga cututtuka na mycoplasma a cikin mata suna bada shawara tare da halayen maganin arthritis na rheumatoid a cikin mata.
Ciwon asibiti
An fara kokarin tabbatar da tasirin tarin kwayar tetracycline kuma an ruwaito shi a kan shekaru 40 da suka wuce daga Thomas McPherson Brown, MD. Makonni biyu bayan mutuwar Brown a shekarar 1989, NIH ta bukaci a ba da takardun gwaji don gwaje-gwajen gwaji na tsarin tumracycline don maganin cututtuka wanda ya ke nema. Sakamakon farko na jarrabawar gwaji, wanda aka sani yanzu kamar MIRA ko Minocycline a Rheumatoid Arthritis, sun yi alƙawari kuma NIH ta buƙaci takardun neman aikace-aikace don nazarin mycoplasma da sauran magungunan cutar masu cutar asibitoci a cikin asibiti a 1993, kuma bincike na gwaji don maganin rigakafin cutar rheumatoid arthritis a 1994.
Sakamakon gwajin gwaji na MIRA ya bayyana cewa, "Marasa lafiya wadanda ke fama da mummunar RA yanzu suna da zabi na wani wakili na asibiti. Ba kwayoyin cututtuka ba kawai sun rage yawan bayyanar cututtuka, amma illa masu illa sun kasance kadan kuma basu da tsanani fiye da yadda aka lura da yawancin sauran Rheumatoid jiyya. "
"Me ya sa Arthritis?"
A cikin shekarun da suka gabata, dabarun da ke mayar da hankali ga mycoplasma a matsayin mai kula da cututtukan masu dauke da cututtuka kuma a kan tetracycline a matsayin magungunan maganin kwayoyin cutar da aka zaba sun ɓaci saboda rashin isasshen kudade don ƙarin bincike da siyasa.
"Me ya sa Arthritis?" Harold W. Clark, Ph.D., ɗaya daga cikin abokan aiki na Brown, yayi nazarin cututtuka na rheumatoid, shekarun bincike, bincike don maganin wariyar zuciya, da kuma takaici da masu binciken wadanda basu da kwarewa a kan shekaru 40 na maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin maganin magance cutar gwamnati da wasu kungiyoyin arthritis. Clark ya yi imanin cewa, an hana ƙoƙari saboda rashin lafiya, magani mai sauƙi yana wulakanta wurin likita tun lokacin da marasa lafiya ke buƙatar samun agajin likita.
Yawancin likitoci sun kasance masu shakka kuma basu bada shawarar maganin kwayoyin cutar ga marasa lafiya. Asalin Ciwon Arthritis ya zama alama ba tare da komai ba bayan magungunan maganin kwayoyin cutar da aka yi la'akari da shi lafiya da tasiri.
Ma'aikatar likita ta asali ta shaida cewa ba ya kula da magani a matsayin nasara ba kuma ana buƙatar ƙarin nazarin aikace-aikace da kuma amfani da minocycline na dindindin.
Bisa ga Cibiyar Harkokin Rheumatology ta Amirka, "an tsara wa Minocycline alamun cututtuka na cututtuka na rheumatoid mai yalwaci. A wani lokacin ana hade shi da wasu magunguna don magance marasa lafiya da alamun bayyanar cututtukan wannan nau'in maganin wariyar launin fata."
Sources:
Me yasa Arthritis? Binciken Dalilin da Cure na Rheumatoid Arthritis, by Harold W. Clark, Ph.D., 1997
Cannon, Michael. Minocycline (Minocin). Kwalejin Amirka na Rheumatology. Updated Maris 2015.