Magunguna don dakatar da COX bazai zama abu mai kyau ba
Pain da ƙumburi, ƙaddamarwa na farko na yawancin mutane a wasu lokuta a rayuwar su da kuma abin da ke faruwa yau da kullum ga mutane da yawa da cututtukan arthritis, an haifar da shi ne ta hanyar cyclooxygenase, ko COX, don gajeren lokaci.
COX wani enzyme ne wanda ya haifar da prostanoids- prostaglandins , prostacyclins, da thromboxanes-wanda duk suna da alhakin amsawar ƙwayar cuta.
Ya nuna cewa COX ba kome ba ne, yana da mahimmanci don tafiyar da al'amuran salula.
Drugs da nufin dakatar da COX don kawar da ƙumburi, suna kama da kyakkyawar ra'ayi, amma ta hanyar hana COX, akwai raguwa.
COX-1 Cikin COX-2
A shekarun 1990s, an gano cewa akwai nau'i biyu na enzyme COX-1 da COX-2. Ƙarshen ita ce mafi mahimmanci na biyu. COX-1 an san shi a cikin mafi yawan kyallen takarda. A cikin gastrointestinal tract, COX-1 yana riƙe da al'ada na al'ada na ciki kuma yana kare ƙwayarwa daga juices na narkewa. Har ila yau, enzyme yana cikin aikin koda da kuma platelet. COX-2 an samo asali a shafukan kumburi.
Dukansu COX-1 da COX-2 na iya haifar da ciwo da ƙumburi, amma tun da yake COX-1 yana da amfani da enzyme mai amfani, ta yin amfani da kwayoyi don hana shi ba zai zama kyakkyawan ra'ayin ba.
NSAIDs hana COX
Magungunan anti-inflammatory marasa lafiya (NSAIDs), waɗanda ake wajabta don bi da cututtuka, aiki ta hanyar hana prostaglandins. Harkokin gargajiya NSAIDs, irin su ibuprofen da naproxen, na iya haifar da matsalolin gastrointestinal ciki har da ulcers .
Wadannan NSAID basu da ma'ana, ma'anar suna hana biyu COX-1 da COX-2. Hanya ta COX-2 ta hanyar gargajiya NSAIDs yana da amfani ga sakamako mai kumburi, amma ragewa shine hanawa na COX-1 zai iya haifar da illa mai lalacewa irin su ulcers, tsawon lokaci na jini da kuma matsaloli na koda.
COX-2 Zaɓaɓɓun NSAIDs
A karshen shekarun 1990, kamfanonin ƙwayoyi sun ci gaba da samun magungunan da suka dace da kawai COX-2, waɗannan NSAID ne Celebrex, Vioxx, da Bextra.
Daga cikin waɗannan, Celebrex ne kawai magani wanda ya kasance a kasuwa a Amurka kuma yana da akwatin fata na gargadi cewa yana dauke da hadarin ciwon zuciya da kuma bugun jini.
Tun lokacin da aka janye Vioxx a shekara ta 2004, Cibiyar Abinci da Drugta ta Amurka ta bincikar dukkanin magungunan, ciki har da dukkan maƙalafan NSAIDs da COX-2 wadanda aka sayar da su a kan kaya ko kuma takardun magani, kuma sun kara da gargadi na akwatin fata a kan umarnin umarnin. .
Ƙwararruwan COX-2 guda biyu, Arcoxia da Prexige, waɗanda suke amfani da su a wasu ƙasashe, FDA sun ƙi. An cire tsokaci daga kasuwa a Ostiraliya da Kanada saboda matsalolin hanta.
Wasu masu bincike sunyi imani, bayan samun ƙananan ƙananan COX-2 a wasu jikin da ba a taɓa ƙurawa ba, COX-2 na iya taka rawar a wasu al'amuran al'ada ba tare da kumburi ba. Masu bincike a Birtaniya sun gano cewa COX-2 na iya karewa daga atherosclerosis, lokaci na likita don karfafawa na maganin, kunsa da clogging.
Yayin da masu la'akari da NSAIDs da COX-2 suna dauke da maganin magunguna masu mahimmanci don marasa lafiya na arthritis , dole ne a yi la'akari da amfani da hadari ga kowane mutum mai haƙuri. Kwayar cutar Cardiac kuma mafi kyawun NSAID don amfani ya kamata a kimanta.
> Sources
> Foundation na Arthritis. NSAIDs.
> Bathon, Joan M. Magana game da Specific COX-2 Masu hanawa. Cibiyar Arthritis Johns Hopkins.
> Kirkby N, Lundberg M, Wright W, Warner T, Paul-Clark M, Mitchell, J. COX-2 Kare kariya daga Atherosclerosis Tsayawa daga Tsarin Tsarin Mulki na Ƙasar: Tabbatar da hanyoyin COX-2 Ƙungiya mai Rgl1 da Lymphocyte Networks. PLOS Daya. Yuni 2, 2014.