Ƙididdiga kamar yadda ya faru ga CFS
Me ya haifar da ciwo mai tsanani? M tambaya! Duk da kuri'a na bincike, masana ba su iya ba da shi a kan wani dalili ba. Wasu suna jin ƙin ciwo na gajiya ( ME / CFS ) na iya haifar da abubuwa masu yawa suna zuwa tare a ƙarƙashin yanayin da ya dace. Wadannan dalilai na iya hada da:
- Bayanan halitta
- Tsarin tsakiya na juyayi (CNS) da kuma mummunan halayen hormone
- Kwayar cuta ko wasu kamuwa da cuta
- Kuskuren abubuwan da ba su da kyau
- Yanayin damuwa
- Bayyana zuwa toxins
Ba duk wanda ke tare da ME / CFS yana da waɗannan abubuwan da suke faruwa ba. Wataƙila suna haɗuwa da su cewa, saboda wani dalili, ya haifar da yanayin. Saboda bambance-bambance daban-daban na dalilai na iya haifar da bayyanar cututtuka da canje-canje a cikin jiki, masana suna gano jinsin ko ƙungiyoyi na ME / CFS. Ƙarshe, ƙaddamarwa zata iya taimaka maka kuma likitanka ya bayyana hanya mafi kyau don bi da ku.
Kayan Halitta
Harkokin bincike na ME / CFS tare da kwayoyin da ke cikin tashar hypothalamic-pituitary-adrenal (HPA) da tsarin jin dadi. Hanya HPA tana sarrafa barcin ku, amsawa ga danniya, da kuma bakin ciki.
A cikin nazarin 2006 da aka buga a Pharmacogenetics , masu bincike sun dubi DNA wanda ke sarrafa yadda jikinka ya haifar da rauni, rauni da damuwa, kuma sun sami sauyawar juna wanda zai iya yin la'akari da ME / CFS da kashi 76 cikin daidaituwa.
CDC ta kira wannan "shaidar farko ta tabbatar da hujjoji na tushen tsarin rayuwa don ciwo mai wuya." Duk da haka, masu bincike ba su iya nuna alamun kwayoyin ko ƙayyade yadda bambancin ya shafi rinjaye ba.
Sauran binciken suna nuna irin abubuwan da ke faruwa a cikin mutanen da ke dauke da ME / CFS da ke tasiri ga aikin da ba su aiki ba, sadarwa ta hanyar salula, da kuma yadda hanyoyin ku ke samun makamashi.
Dukkan wannan yana nuna cewa wasu mutane za su iya kasancewa a gaba ga MU / CFS - a wasu kalmomi, za su iya samuwa idan an sami haɗari. Alal misali, idan wani wanda ya riga ya yi tunanin yana faruwa a cikin wani lokaci mai wahala kuma an bayyana shi zuwa wata cuta ko rashin lafiya, za su ci gaba da ME / CFS. Wani wanda ke da tsararren kwayoyin halitta, duk da haka, zai zo ta hanyar wannan labari kuma ya zama lafiya.
CNS & Hormones
Kamar yadda aka ambata a sama, wasu mutane tare da ME / CFS suna da matsala a cikin HIS axis. Masu bincike suna da sha'awar wasu daga cikin sunadarai masu tsatstsauran ra'ayi da kuma hormones waɗanda aka sarrafa ta wurin HPA axis:
- Canjin yanayi na Neurotransmitter
Neurotransmitters sune sunadaran da ke sadarwa saƙonni a kwakwalwarka. Bincike ya nuna cewa wasu mutane tare da ME / CFS suna da matakan haɗari da wasu mahimmancin ma'adinan ( serotonin da dopamine ). Masu bincike suna aiki ne don bayyana muhimmancin wadannan abubuwan haɗari a cikin ME / CFS. - Tashin damuwa na hormone
Masana sun san cewa matakan damuwa cortisol sunyi rauni a marasa lafiya na ME / CFS, kuma sunyi imani wannan zai iya zama abin da ke wuyar magance matsalolin - ko dai jiki (irin su kamuwa da cuta ko aiki) ko tunanin mutum. Cortisol sauyawa yana taimaka wa wasu, amma ba duka ba, masu lafiya ME / CFS. A cikin binciken 2008, matan da ke dauke da ME / CFS suna da matakan cortisol da safe yayin da maza da ME / CFS ba su da, wanda zai iya taimakawa wajen bayyana dalilin da ya sa yanayin yafi kowa a cikin mata.
- Tsarin circadian rhythms
Tsawon circadian (ɓangare na HPA axis) yana tsara tsarin layinka na barci. Shaidun yana nuna cewa a wasu mutane tare da ME / CFS wannan agogo an kashe, mai yiwuwa ta hanyar tunani ko ta jiki, kuma jiki ba zai iya samun damar sake dawowa ba. Mutanen da ke cikin wannan matsala suna nuna karin lokaci a lokacin motsi na ido (REM) na barci, wanda shine lokacin da kuke mafarki. Mutane a cikin wannan rukuni na ME / CFS sun sami ƙarin taimako daga magunguna na barci fiye da mutane a cikin wasu rukuni, bisa ga masana.
Cutar
Yawancin alamomi da alamomi na ME / CFS sunyi kama da wadanda ke da cututtuka, don haka bincike mai yawa ya mayar da hankali kan yiwuwar kamuwa da cutar bidiyo.
Masu bincike sun bincika abubuwa uku masu kamuwa da cutar, duk da haka babu wanda aka tabbatar da:
- Kwayar cutar ko kwayoyin cuta ta shafi jiki kuma tana lalata tsarin tsarin rigakafi. Rashin lalacewa ya ci gaba da haifar da kamuwa da kamuwa da cututtuka ko da bayan kwayar cuta ko kwayoyin sun tafi.
- Bayan wani kamuwa da cuta, wani abu mai mahimmanci ta hanyar tsarin rigakafi yana haifar da cutar da ta zama mai aiki don sake sakewa.
- Amsawa na likita don maganin cututtukan cututtuka yana faruwa a cikin mutanen da suke da sauƙi.
Duk da yake ba duk wanda ke tare da ME / CFS ya nuna alamun kamuwa da cuta, mutane da yawa suna aikatawa. Shaidu da dama suna tallafawa ka'idar cewa wasu MA / CFS suna haifar da wani ɓangare ta hanyar cutar:
- Interovirus dangane
A cikin binciken 2007, mutanen da ke dauke da ME / CFS sun kasance sau hudu fiye da masu lafiya don samun shaida na masu shiga cikin ciki. Masu shigarwa suna haifar da cututtukan ciki, kuma bayyanar cututtuka na ME / CFS sukan fara bayan irin wannan rashin lafiya. - Rnase L
Jikinka yana amfani da enzyme Rnase L don kashe ƙwayoyin cuta da ke kai hare-hare a jikinka, kuma marasa lafiya na ME / CFS da yawa suna da aikin Rnase L. - Killer Killer (NK) Cells da T Cells
Kwayoyin NK & T da ke cikin kwayar cutar da ke dauke da kwayoyin cutar ta HIV, kuma mutanen da ke dauke da ME / CFS sun shafe ayyukan NK da T da lambobi, suna bada shawara cewa aiki na yau da kullum zai iya zama mai tsanani da kuma rage su. - Antibodies
Mutanen da ke dauke da ME / CFS suna da ƙwayoyin magunguna ga yawancin kwayoyin cuta masu cutar da ke haifar da gajiya da sauran alamu na MU / CFS. Wadannan kwayoyin sun haɗa da wadanda ke haifar da candida (yisti), irin kwayoyin herpesvirus ta 6 (HHV-6), kyanda, parvovirus, da Epstein-Barr . Masu bincike basu iya nuna cewa duk wani abu ne mai muhimmanci na ME / CFS ba. - Maganin rashin lafiya a farkon
Har zuwa kashi 80 na lokuta na ME / CFS farawa ba zato ba tsammani bayan yanayin jini. - Cluster annobar cutar
Yayin da CDC bai tabbatar da yawancin annobar ɓarna ba, rahotanni na mutane da yawa a cikin gida guda, wurin aiki, da kuma al'umma masu tasowa ME / CFS a lokaci guda ba a taɓa ji ba.
Wasu masu bincike sun nuna cewa canje-canje a cikin kwayoyin cutar marar kyau a cikin hanji na iya taka muhimmiyar rawa wajen bunkasa ME / CFS.
Duk da haka, wasu shaidu sunyi kama da maganin ka'idar maganin hoto. ME / CFS ba ya bayyana yadawa ta hanyar abun ciki ta dace, mutanen da ba tare da shi ba sun bayyana kwatsam, kuma - duk da nazarin da aka tsara - masu bincike sun kasa iya danganta ME / CFS tare da wasu cututtuka.
A Note Game da XMRV
A shekarar 2009, masu bincike daga Cibiyar Wiki na Whittemore Peterson (WPI) sun wallafa wani binciken a cikin mujallolin Kimiyya wanda ya nuna ma'ana tsakanin XMRV, sabon binciken retrovirus, da ME / CFS. Sun sami XMRV a cikin kimanin kashi 67% na samfurorin jini daga marasa lafiya na ME / CFS. Sun kuma gano shi a cikin kashi 3 cikin dari na sarrafa lafiya.
Duk da haka, binciken baya ya tabbatar da hanyar haɗi, ciki har da babban binciken da ya haɗa da mai binciken WPI. Sauran binciken da aka nuna yana nufin wanda cutar ta iya haifar da halayen ƙarya a binciken farko. Da marigayi 2011, ka'idar XMRV ta kasance duka-amma watsi.
Tsarin Rashin Jima'i
Yawancin karatu sun nuna rashin daidaituwa a cikin tsarin kulawa da mutane tare da ME / CFS, amma masu bincike ba su samo alamun abubuwan rashin haɗari ba. Daga cikin mafi yawan sune kwayoyin cuta ne da kuma tsarin rigakafi mai mahimmanci.
Wasu bincike sun bayar da rahoton cewa yawancin marasa lafiya na ME / CFS suna shan damuwa da abubuwan ciki har da pollen, abinci da ƙwayoyi irin su nickel da mercury.
Wannan ya haifar da ka'idar cewa allergens na iya haifar da jerin maganganu masu rikitarwa wadanda zasu jagoranci ME / CFS. Ɗaya daga cikin ka'idar ita ce rashin lafiyar, damuwa da kuma kamuwa da cuta zai iya haɗawa don ƙaddamar da sinadaran da ake kira adenosine triphosphate (ATP), wanda ke adana makamashi a cikin sel. Wasu marasa lafiya na ME / CFS sun nuna alamar ƙaddamar da kayan ATP.
Wasu masu lafiya na ME / CFS suna da matakan da ake kira cytokines , wanda masana kimiyya zasu iya haifar da alamun bayyanar ME / CFS, ciki har da gajiya da tsoka. Ɗaukar karatu da yawa sun bayar da rahoton ƙwayar T cell a cikin mutanen da ke dauke da ME / CFS, amma wasu binciken ba su tabbatar da maganin T da cytokine ba.
Mawuyacin ciwo na kwanan baya ya bayyana yana da wasu siffofi na kowa tare da cututtuka irin na lupus ko ƙananan sclerosis , wanda tsarin tsarin na yaudara ya kai wa jikin jiki lafiya. Cibiyar bincike mai zurfi ta nuna cewa ME / CFS na iya zama mai kai tsaye.
Damuwa
Masu bincike sunyi imani da kayan shafawa na mutum, halin mutum da halin zamantakewa na iya tasiri ko za ku ci gaba da ME / CFS, amma basu fahimci cikakken dangantaka tsakanin su ba.
Duk da yake waɗannan dalilai bazai zama ainihin dalilin ME / CFS ba, suna iya taka muhimmiyar rawa wajen sanya ka mai saukin kamuwa.
Lura: ME / CFS ba la'akari da rashin lafiya na farko, kuma ba shi da ME / CFS yana nufin mutum yana da rauni ko rashin iya magance abubuwa. Yayin da wani lokaci ana danganta shi da ciwon zuciya, ME / CFS wani yanayi ne mai ban mamaki.
Chemicals / Toxins
A cikin rukuni guda ɗaya, wahala da zafi suna da alaƙa tare da nunawa ga wasu sunadarai da mawuyacin muhalli. Wadannan zasu iya haɗawa da ƙwayoyi, magungunan kashe qwari ko ƙananan ƙarfe. Duk da haka, saboda yawancin mu an bayyana su ga wadannan nau'ikan sunadarai a wasu mahimmanci, yana da wuyar sauke abin da waɗannan zasu iya haifar da matsaloli. Wani yanayin da ake kira ƙwarewar magunguna da yawa (MCS) yana haifar da yawancin alamu kamar ME / CFS, kuma an yarda da su biyu a matsayin yanayin haɗuwa .
Sources:
Cibiyoyin Kula da Cututtuka da Cututtuka na 2006. "Matsaloli masu yiwuwa"
Dokta Chia. Copyright 2005 Co-Cure. Duk haƙƙoƙin haƙƙin mallaka. "The rawar da enterovirus a na kullum gajiya ciwo"
Kaiser J. Kimiyya. 2011 Janairu 7; 331 (6013): 17. Mawuyacin ciwo mai wuya. Nazarin yana nuna yiwuwar cutar a cikin binciken XMRV.
Lombardi VC, et al. Kimiyya. 2009 Oktoba 23; 326 (5952): 585-9. Detection wani mai ciwon maɗamfari retrovirus, XMRV, a cikin jini kwayoyin mutane da na kullum gajiya ciwo
Nater UM, et al. Littafin jarida na endocrinology da metabolism. 2008 Mar; 93 (3): 703-9. Turawa a cikin sallar cortisol salutary salutary salula a cikin yawan mutanen da suke nazarin yawan mutane tare da ciwo mai wuya da ciwo da kyau.
Simmons G, et. al. Kimiyya. 2011 Nuwamba 11; 334 (6057): 814-7. Rashin tabbatar da XMRV / MLVs a cikin jinin marasa lafiya da ciwo mai wuya kullum: binciken bincike-bincike da yawa.
Vernon, S. Pharmacogenomics, Afrilu 2006; kundi 7: shafi na 345-354. Kalubale na haɗuwa da bayanai mai zurfi: bayanai na annoba, na asibiti da kuma dakin binciken da aka tattara a lokacin binciken binciken asibiti na ciwo mai wuya.