Abin da muka sani game da shi
Har yanzu kuna jin cewa ciwo mai wuya ( ME / CFS ) shine "rashin lafiya na asiri," amma yanayin da sassan cutar ke farawa, saboda godiya ga masu bincike. A cikin shekaru, musamman ma 'yan kwanan nan, mun koyi babban adadi. Wasu daga cikin wannan ilimin ya nuna matsayin cewa kumburi da haɓakawa na iya zama a cikin wannan rashin lafiya.
Don fahimtar bincike, yana taimaka wajen sanin kadan game da tafiyar da kansu.
Kumburi: Amfani & Kyau
Dukanmu mun sani cewa ƙonewa yana cikin cututtuka da raunuka da yawa, kuma yana da wuya a sami gidan da ba ya ƙunshe da akalla daya daga cikin kwayoyi masu guba . Muna kankara da kuma tayar da raunin mu, don kiyaye su daga yin fushi.
Duk da haka, yana iya mamakin ka koyi cewa ƙumburi yana cikin ɓangaren maganin lafiya a cikin jiki. Lokacin da tsarinka ya gano matsala-ko yana zama kwayar cutar ko kwayoyin cuta, ko kyallen takarda da ke lalacewa daga rauni-shi yana haifar da amsa mai kumburi.
Abin da ya faru shi ne cewa jini yana canzawa don samun ƙarin jini zuwa yankin, kuma an gina karin gina jiki a cikin wannan jini. Kwayoyin jinin jini suna motsawa daga jini zuwa cikin matsala kuma sun kashe ko tsaftace wani abu da bai dace ba. Sa'an nan nama zai iya fara warkar.
Don haka, idan kun kunya ko ku kunkatar da idon kuɗi, kadan kumburi abu ne mai kyau.
Yana nufin tsarin warkarwa yana aiki.
A gefe guda kuma, lokacin da kumburi ya ci gaba da ciwo saboda lalacewar da ta ci gaba ko kuma mummunan tsarin lalata, to, kuna da matsala.
Misali na lalacewar da zai ci gaba zai iya zama wani abu kamar ciwo mai raɗaɗi daga rauni wanda mummunar matsayi ya ci gaba, ko maimaita lalacewar saboda cutar.
Wata mummunan tsarin da ba shi da ma'ana ba zai iya nuna mahimmanci ba.
Aminiya: Asalin Misfi
A cikin kwatsam, jiki yana fama da wutar wuta. Tsarin na rigakafi ya tafi haywire kuma yanzu ya gano ɓangaren jikinka a matsayin mai haɗari na kasashen waje. Wannan yana haifar da ƙwayar kumburi kuma yana aikawa cikin ƙwayoyin musamman don halakar da manufa kuma fara aikin warkarwa.
A halin yanzu, tsari na warkarwa ya haifar da komai daga duk jikin da jikinka ba ya so, don haka tsari ya ci gaba har abada.
Yana da mahimmanci a lura cewa ba duk wani damewa ba ne kawai.
ME / CFS: Menene Muke Sanuwa?
Masu bincike sun dade da yawa cewa ME / CFS da ke ciwon kumburi. Nazarin ya nuna mutane da dama masu cin hanci da kumburi da kuma ci gaba da maganin jinin marasa lafiya na ME / CFS. Wasu masu bincike sunyi la'akari da cewa ME / CFS ya zama cutar ne ko cutar neuroendocrineimmune.
Duk da haka, muna ci gaba da koyo game da muhimmancin kumburi a cikin yanayin. Binciken da aka yi kwanan nan ya nuna hotunan hoto game da moriyar juna. Kuma a lokacin da aka ba da kyauta, wata babbar tambaya ita ce: menene manufa?
Matsaloli masu yiwuwa na Kumburi
Mafi yawan masu bincike na kamfanin ME / CFS suna daukan ƙunawa kamar yadda aka ba. A madadin sunan myalgic encephalitis (ME), wanda wasu masu bincike suka karɓa, ƙananan ƙwayoyin cuta yana nufin ƙonewa da kwakwalwa.
Wasu masu bincike sun nuna yiwuwar ƙin ƙuri'a wanda ba ya haɓaka bautar mutum.
Nazarin binciken da aka yi na 2012 wanda yake ƙoƙari ya rabu da gajiya mai tsanani, rashin ciwo mai wuya, da ƙananan ƙwaƙwalwar ƙwayar cuta a cikin sassa daban-daban sun gano cewa marasa lafiyar WHO suna da matakai masu girma na cytokines interleukin-1 da necrosis factor alpha da neopterin, wanda shine alamar pro-inflammatory na rigakafin aiki.
Kwanan nan, binciken ya nuna cewa alamomi na ƙwayoyin cuta na iya rarrabe yanayin da ke ciki ko rashin lafiya.
Wani binciken da aka wallafa a cikin ƙwayar cuta na Brain cuta shine daya daga cikin jiki mai girma idan yayi la'akari da matakan oxyidative da nitrosative (O & NS) tare da matakan antioxidant marasa ƙarfi matashi mai yiwuwa na ME / CFS, yana cewa wadannan abubuwan zasu iya nunawa ga tsarin ilimin immuno-inflammatory.
(Ƙara koyo game da wannan ka'idar: Matsalar Harkokin Ƙari da Tsarin Mulki .)
Sauran masu binciken sun nuna cewa wasu pathogens na iya, a cikin mutanen da suka rigaya suka fara, suna haifar da wani cigaba da ba da izini ba, wanda zai haifar da kumburi da kuma matsalolin matsaloli. Daya daga cikin manyan abubuwan da ake zargi a wannan labarin shine cutar Epstein-Barr , wanda ke haifar da mononucleosis ("cutar kissing").
Bincike na shekara ta 2013 ya binciko alamun ayyukan raya ƙwayar cuta a cikin gut bisa ka'idar cewa, ta hanyar kwakwalwar kwakwalwa, haɗuwa da kututturewa zai haifar da kumburi na kwakwalwa. Masu bincike sun sami wasu shaidun, amma wannan karami ne, binciken farko kuma yawancin aiki ya kasance a wannan yanki.
Shari'ar Kare Kai tsaye
Wasu masu bincike sun gano shaidun da ke nuna cewa ME / CFS shine, akalla a cikin wani ɓangare, cutar marasa lafiya. An gabatar da wasu kullun daban-daban na tsarin rashin daidaituwa.
A cikin nazarin binciken da aka yi a shekara ta 2013 game da yiwuwar O & NS da kuma ba da kyauta, masu bincike sun ce, kasancewa na cytokine mai ba da kariya da wasu wasu dysfunctions da aka sani da ME / CFS na iya jaddada ku ga haɓaka. Wannan yana nufin aiki na motsa jiki na iya zama sakamakon yanayin maimakon a dalilin shi. Wadannan masu bincike suna tsammanin ciwon cututtuka na sauri zai iya haifar da wasu matakai na yau da kullum wanda zai iya haifar da samfurin sirri: ta hanyar dakatarwa da kwayoyin mimicry.
A cikin kwayoyin mimicry, tsarin na rigakafi yana yaki da kwayar cuta mai ciwon jini sannan sai ya fara rikita shi da irin wannan cell a cikin jiki kuma don haka ya fara kai hare-hare. Ainihin, saboda duka kwayoyin sunyi kama da duck, tsarin na rigakafi yana nuna su duka biyu, lokacin da yake daya daga cikin goose, kuma gishiri yana cikin wannan yanayin.
A yayin da ake kunnawa, jikin mutum ya kai hari ta hanyar cutar, tsarin na rigakafi yana amsawa ta hanyar kunna ƙananan sel, kuma, saboda wasu dalili, yin amfani da kuskuren yana haifar da wani nau'i daban-daban na kwayar halitta-cellular autoimmune-wanda ke fara kai hare-hare ga jikin jikin.
A cikin wannan binciken, masu bincike sun kuma rubuta wasu hanyoyi da ME / CFS zasu iya haifar da kai tsaye, ciki har da dysfunction na mitochondria, wanda zai samar da makamashi zuwa sel dinku, da lalata salon salula wanda O & NS ya haifar da yaduwar tsarinku don ɓatar da su.
Binciken daban-daban na 2013 wanda ya shafi yawancin masu bincike guda daya ya nuna yiwuwar samun karfin jiki zuwa 5-HT, wanda aka fi sani da serotonin . A matsayin hormone da neurotransmitter, serotonin yana da matakai masu muhimmanci a duka gut da kwakwalwa. An yi tsammanin dysregulation na Serotonin ya shiga cikin ME / CFS.
Masu bincike sun ce kawai fiye da kashi 60 cikin dari na mahalarta tare da ME / CFS sun gwada gwagwarmaya don aiki na autoimmune da 5-HT-fiye da sau goma a cikin rukunin kulawa, kuma sun rage yawan wadanda ke da gajiya mai dorewa hadu da masu adawa da ME / CFS.
Shin Amsoshi Da dama Za Su Daidai?
A ƙarshe, zai yiwu cewa lokuta daban-daban na ME / CFS suna da lahani daban-daban na ƙonewa, kuma wasu lokuta ne na haɓakacce yayin da wasu ba su da. Ka tuna cewa I / CFS na iya bambanta sosai daga mutum ɗaya zuwa wani. Yana iya zama cewa ƙungiyoyin raƙuman daban daban, kuma watakila ma cututtuka daban-daban, yanzu an jefa su a kwandon ɗaya.
Har yanzu masana kimiyya suna aiki don warware dukkanin su. A halin yanzu, kana buƙatar samun hanyoyin da za a gudanar da yanayinka. Yana da mahimmanci ka yi aiki tare da likitanka don sanin ainihin yanayinka na ME / CFS da kuma yadda za a magance shi.
Sources:
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Arnett SV, Clark IA. Journal of Disefect Disorders. 2012 Dec 10; 141 (2-3): 130-42. Rashin gajiya da cututtukan ƙwayar cuta - marasa galihu don ganewa da kuma kula da ciwo mai wuya.
De Meirleir KL, et al. A cikin Vivo. 2013 Mar-Apr, 27 (2): 177-87. Kwayoyin dendritic Plasmacytoid a cikin duodenum na mutanen da aka bincikar su tare da maganin encephalomyelitis na myalgic sun kasance marasa amfani ga kwayoyin cuta zuwa ga sunadarai na retroviral.
Fujinami RS, et al. Bincike na kwayoyin halitta. 2006 Janairu 19 (1): 80-94. Mimicry kwayoyin halitta, maye gurbinta, ko ci gaba da kyamarar cututtuka: cututtuka da cututtuka na autoimmune.
Maes M, Ringel K, et al. Labarai na cuta m. 2013 Sep 5, 150 (2): 223-30. A cikin cututtukan ƙwayar cuta na ciwon zuciya / ciwo mai tsanani, kara yawan aiki na autoimmune a kan 5-HT an hade da hanyoyin immuno-inflammatory da ƙwayar cuta na kwayan.
Maes M, Fisk FN, Johnson C. Psychiatry bincike. 2012 Dec 30, 200 (2-3): 754-60. Ƙwararrun ƙwaƙwalwar ƙwaƙwalwa (ME), Ciwo na Yara da Gwaji (CFS), da Ƙarfin Tarihi (CF) an bambanta daidai: sakamakon binciken ilimin binciken da ake amfani da shi a kan asibitoci da kuma ƙananan bayanai.
Maes M, Fisk FN, Ringel K. Psychotherapy da psychosomatics. 2012; 81 (5): 286-95. Magungunan ƙwayoyin cuta da ƙwayoyin salula sun lalata magunguna a cikin cututtukan ƙwaƙwalwar ƙwaƙwalwar ƙwayar cuta / ciwo mai tsanani da rashin ciwo: alamomin kumburi sun fi girma a cikin cututtukan ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar cuta / ciwo mai tsanani fiye da ciki.
Morris G, Anderson G, et al. BMC magani. 2013 Mar 8; 11: 64. Rahoton nazari game da kamance da rashin daidaituwa a tsakanin maganin ƙwaƙwalwar ƙwaƙwalwar cuta / ciwo mai tsanani (ME / CFS) da halin rashin lafiya.
Morris G, Berk M, et al. Neurobiology kwayoyin halitta. 2013 Sep 26. [Epub gaba da bugawa] Matsayi na ɓatacciyar haɓakawa a cikin cututtukan ƙwaƙwalwar ƙwaƙwalwar cuta / ciwo mai tsanani (me / cfs).
Morris G, Maes M. Metabolic cutar kwakwalwa. 2012 Jun 21. Kyakkyawan samfurin neuro-immune na Myalgic Encephalomyelitis / Balance gajiya ciwo.