Shin Nitric Oxide Bayan Bayanan Waɗannan?
Wasu masu bincike sunyi zaton cewa ciwo mai wuya (CFS ko ME / CFS ) da fibromyalgia (FMS) na iya zama dalili daya. Wani mai bincike ya ce dalilin hakan shine nitric oxide kuma yana da alhakin ƙwayar magungunan ƙwayoyin cuta (MCS) da cututtukan cututtuka na post-traumatic (PTSD).
Martin Pall, PHD, Farfesa ne na ilmin kwayoyin halittu a jami'ar Washington State kuma ya fara neman MU / CFS bayan an gano shi da shi.
Dalilin ka'idarsa shi ne cewa matsalolin dan lokaci na haifar da haɓakaccen yanayi na nitric oxide, wanda ya fara zagaye mai banƙyama kuma yana haifar da rashin lafiya.
Yana da muhimmanci a tuna cewa wannan yarjejeniya na gwaji ne kuma ba a tabbatar da shi ba a kimiyya. Duk da haka, yawan karatun da ake yi, suna goyon bayan ka'idodin hanyoyin da ba su da kyau, kuma wasu mutanen da suka yi kokarin bin ka'idar sun ce ya yi aiki a gare su.
Bayanan da aka ba da shi ba don tallafawa ko ƙin ka'idar Pall ba amma yana nan don sanar da ku game da ka'idojin da aka samo da kuma maganin kulawa don ku iya yanke shawara. Yana da muhimmanci a hada da likitanku a cikin yanke shawara kuma ku kula da kowane canje-canje ga lafiyarku.
Nitric Oxide a cikin Jiki
Nitric oxide (NO) yana cikin jikinka kuma tana taka muhimmiyar rawa kamar rinjayar hadarin oxygen zuwa kyallen jikinka da aikawa da kwarjin jijiya.
Har zuwa ƙarshen shekarun 1990, duk da haka, an yi la'akari da shi ne kuma Pall yayi la'akari da shi a cikin ka'idarsa. Ɗaukar karatu da yawa sun nuna canje-canje ga tsarin kulawa na tsakiya na mutane da FMS da ME / CFS, kuma Pall ya ce waɗannan canje-canje na bukatar matsayi mai girma na NO.
Pall ya ce babban matakan da ke cikin tsarin kulawa na tsakiya, daga bisani, haifar da matakan peroxynitrite, wanda zai haifar da lalacewar nama.
Ta yaya kake samun yawa NO a jikinka? Pall ya fitar da ƙarfafawa 12, 8 wanda ke haifar da karuwa ta kai tsaye, 4 wanda ke kaiwa zuwa wani abu mai kai tsaye. Dandalin da ke tsaye shine:
- Abun kamuwa da kwayoyi (ME / CFS, FMS)
- Kwayar cuta ta kwayar cuta (ME / CFS, FMS)
- Cutar jiki (ME / CFS, FMS, PTSD)
- Ƙararren mota na man fetur (ME / CFS)
- Ruwan pesticide mai daukan hoto (ME / CFS, MCS)
- Toxoplasmosis kamuwa da cuta (ME / CFS)
- Ƙananan ƙwayoyi masu yaduwa (MCS)
- Cututtuka na Autoimmune (FMS ta biyu)
Sauran wasu ƙarfafa 4 suna haifar da amsa wanda zai haifar da ƙarin aikin mai karɓar NMDA, wanda aka sani don ƙara yawan nauyin NAS da peroxynitrite (ONOO-). (Masu karɓar NMDA aika sakonni a cikin kwakwalwa kuma zasu iya shiga cikin lalacewar lalacewar.) Wadannan danniya sune:
- Babban damuwa na tunani (FMS, PTSD)
- Ciguatoxin daukan hotuna (daga abincin teku) (ME / CFS)
- Organochlorine magungunan kashe qwari (MCS)
- Pyrethroid magungunan kashe qwari (MCS)
Lura: Babu matakan karuwa saboda sakamakon wasu abubuwa masu mahimmanci, kamar su lokacin da kuke motsa jiki, ku ci abincin mai-mai-rage, inganta yawan abincin ku ko ƙyale shan taba, duk waɗanda masana suka yi la'akari da amfanin mutane da FMS da ME / CFS. Mutane da yawa masu bincike sunyi la'akari da matsayi mai girma Babu matakai don lafiyar ku.
Ƙungiyar Vicious
Pall yayi shawara cewa da zarar danniya ya haifar da gina NO, yana motsa wani zagaye mai banƙyama wanda ya ƙunshi madaukai masu tsalle-tsalle.
Daga can, yana da ƙwarewa sosai da wuya a fahimta sai dai idan kuna da masaniya game da biochemistry. Idan kun kasance, Pall yana da cikakken zane akan shafin yanar gizonsa. Ga sauranmu, a nan misali ne na yadda kawai mataki na 5-mataki yake aiki:
- High NO matakin qara peroxynitrite matakin;
- Hanyoyin peroxynitrite sukan haifar da danniya na oxyidative (ƙaddara kwayoyin halitta cewa lalacewar kwayoyin halitta.
- Ƙananan danniya yana ƙarfafa NF-kB (wanda yake nuna alamar jinsin da ke cikin rikici da salon salula);
- NF-kB ƙara ƙaruwa na samar da enzyme iNOS (inducible nitric oxide synthase);
- iNOS yana ƙaruwa ba matakin, kuma mun dawo zuwa mataki daya.
Pall ya kirkiro zagaye mai mahimmanci na NO / ONOO- (kalmar "a'a, oh no!"). Ya ce yana faruwa ne a wani salon salula, wanda shine dalilin da yasa mutum zai iya ciwo yayin da wadanda ke kusa da shi suna da kyau. Ya kuma bayyana dalilin da yasa cututtuka na iya bambanta da yawa daga mutum ɗaya zuwa wani.
Kwayar cututtukan cututtuka
Pall ya ce abubuwan da ke cikin NO / ONOO- zai iya bayyana magungunan bayyanar cututtuka da CFS, FMS, MCS da PTSD suka haɗu. (Yana bayar da su a matsayin ƙananan abubuwa, ba a kafa su ba). Wadannan alamun sun hada da:
- Koyo da ƙwaƙwalwar ajiyar ƙwaƙwalwa,
- Rashin gajiya da barci,
- Lokacin zafi mai tsanani,
- Dama da damuwa / kai hari,
- Rashin damuwarsa,
- Madaici ciwon ciwo,
- Abincin abinci,
- Tantancewar rashin hakuri / hypotension (sauke cikin saukar karfin jini lokacin da tsaye ɗin yana sa ka zama m.)
Tsayar da Shirin
Don kwashe sake zagayowar, Pall ya ce ya kamata a "ƙaddamar da tsarin," wanda ma'anar yana nufin jinkirin shi ta hanyar kawar da abubuwan da ke jawo shi. Alal misali, idan damuwa ya sa ka ji muni, dole ne a rage ko gudanar. Bayan haka, ya yi imanin cewa ƙwarewar da ake ciki ya buƙaci nau'in kulawa.
Takardar Pall a kan NO / ONOO- zagaye ya tsara abubuwa masu yawa - yawancin su abubuwan da ke cike da abinci mai gina jiki - cewa ya tsinkaya zai sauke tsarin sake zagayowar. (Ka tuna cewa wannan ka'idar ba ta da kyau kuma waɗannan jami'ai ba su da tabbacin magance wannan ɓangare na cututtuka.) Ya kuma rubuta magungunan magani da likitoci biyar suka yi amfani da su wanda suka sami nasarar magance ɗaya ko fiye daga cikin waɗannan yanayi kuma ya ce magunguna duk zasu iya sauka tsara tsarin sake zagayowar. Kamar yadda yake tare da dukkanin zafin maganin, ya kamata ka yi magana da likitanka game da abin da ke daidai a gare ka.
Pall ba shine kawai wanda yake nuna nitric oxide a matsayin yiwuwar wadannan cututtuka ba. Yawancin masu binciken da ke nazarin aikin NO, musamman a fibromyalgia, suna kira don nazarin ko masu maganin antioxidants suna da magani mai mahimmanci.
Binciken
Tun da littafin Pall wanda ya bayyana ka'idarsa a shekarar 2007, an gudanar da bincike sosai game da rawar nitric oxide a cikin waɗannan yanayi.
A cikin ME / CFS, yawancin nazarin (Sachdeva, Kumar, Gupta) sun bayyana don tallafawa ka'idar, a kalla a cikin nau'i-nau'i.
Wasu nazarin ɗan adam sun ba da tabbaci, ciki har da nazarin binciken shekara 2010 (Suarez) wanda ya nuna rashin ciwo ta hanyar rashin lafiya a cikin ME / CFS. Binciken da aka buga a shekara ta 2014 (Morris) ya nuna cewa yaduwar kwayoyin halitta da kuma nitrosative zai iya fitar da hanyoyin ƙwayoyin cuta da ƙwayoyin ƙwayoyin cuta wanda ke taimakawa wajen maganin cutar.
Duk da haka, akalla binciken daya (Meeus) ya gano babu wani haɗari tsakanin adadin NO a cikin jini da aiki a ME / CFS.
Yawancin karatu (Cimen, Fatima, Sendur) sun goyi bayan ka'idar nitric oxide shiga FMS. Wani (Kim) bai sami muhimmiyar bambanci ba a NO matakan tsakanin ƙungiyar FMS da kulawar lafiya.
Shin Yarjejeniyar Pall din daidai ne a gare ku?
Sai kawai za ka iya yanke shawarar abin da magani yake da kyau a gare ka, kuma ya kamata ka tabbata ka tattauna zabinka da likitanka. Baya ga bangarorin da yawa na wannan yarjejeniyar da ake buƙatar haɗin likita, ya kamata a kula da ku sosai don tabbatar da maganin ba shi da tasiri ga lafiyar ku.
Sources:
Cimen OB, et al. Pain magani. 2009 Jul-Aug 10 (5): 813-8. Arginase, Ayyukan NOS, da kuma siffofin asibiti a cikin marasa lafiya na fibromyalgia.
Fatima G, Das SK, Mahdi AA. Clinical da gwaji rheumatology. 2013 Nov-Dec, 31 (6 Sada 79): S128-33. Danniya mai mahimmanci da sigogin antioxidative da abun ciki na ion a cikin marasa lafiya da ciwo na fibromyalgia: abubuwan da ke faruwa a cikin cututtukan cutar.
Gupta A, Vij G, Chopra K. Journal of Neuroimmunology. 2010 Satumba 14; 226 (1-2): 3-7. Dalili mai yiwuwa na yaduwar magungunan oxidative da kuma maye gurbin immunological a cikin nau'i na linzamin ƙwayar cuta mai tsanani da kuma tayar da ita ta wurin tsantar zaitun.
Kim SK, et al. Clinical da gwaji rheumatology. 2010 Nov-Dec, 28 (6 Sada 63): S71-7. Tsarin tsaka da tsinkaye na cytokine a cikin fibromyalgia.
Kumar A, et al. Littafin Indiya na asibiti. 2011 May, 43 (3): 324-9. Nitric oxulation modulation a cikin aikin karewa kan antidepressants a kan ciwo na kullum gajiya rashin lafiya a cikin mice.
Martin L. Pall, Makarantar Cibiyar Ilimin Ƙirƙirar Jama'a, Jami'ar Jihar Washington. Duk haƙƙoƙin haƙƙin mallaka. "Maganar Cutar Lamba ta Sauya Bayani ga Maganganun Cutar Kwayoyin cuta."
Meeus M, et al. A cikin vivo. 2010 Nov-Dec, 24 (6): 865-9. Nitric oxide concentrations al'ada ne kuma ba tare da alaka da matakin aiki a cikin rashin gajiya rashin wahala: bincike-control-binciken.
Morris G, Maes M. Yanzu neuropharmacology. 2014 Mar, 12 (2): 168-85. Danniya mai mahimmanci da kuma nitrosative da hanyoyi masu ciwon kumburi a cikin marasa lafiya tare da maganin ƙwaƙwalwar ƙwaƙwalwar cuta (ME) / ciwo na gajiya mai tsanani (CFS).
Sachdeva AK, Kuhad A, Chopra K. Brain binciken jarida. 2011 Oktoba 10; 86 (3-4): 165-72. Cigallocatechin yayi nazari akan halayyar ameliorates da kuma biochemical deficits a cikin nau'in kaya na kaya - haifar da ciwo mai wuya ciwo.
Sendur OF, et al. Rheumatology kasa da kasa. 2009 Afrilu 29 (6): 629-33. Magunguna antioxidants da kuma nitric oxide a cikin fibromyalgia: nazarin sarrafawa.
Suarez A, et al. Jaridar lafiyar mata. 2010 Jun; 19 (6): 1073-7. Nitric oxide samar da samfurori a lokacin motsa jiki a cikin ciwo mai wuya ciwo: bincike-control-binciken.