A Dubi Abubuwan Zaɓuɓɓuka
Yawancin masu kwakwalwa (jakadun sunadarai a cikin kwakwalwa) suna fama da fibromyalgia (FMS) da ciwo na gajiya ( ME / CFS ). Yayin da kake ji game da serotonin da norepinephrine, wasu da yawa ba zasu iya daidaitawa ba.
GABA da glutamate neurotransmittes biyu sun bayyana cewa zasu zama dysregulated a FMS da ME / CFS. Matakan Glutamate ko aiki ya bayyana yana da girma, yayin da matakan GABA ko aiki sun kasance marasa ƙarfi.
Glutamate yana karawa-kuma zai iya overstimulate-kwakwalwarka, yayin da GABA ta kwantar da shi. Su zama rashin daidaituwa na iya zama alhakin, akalla a wani ɓangare, saboda damuwa da ke haɗar waɗannan yanayi tare da sauran alamu. (Don ƙarin bayani kan wannan, ga GABA & Glutamate: Sashe na 1. )
Canja wurin aiki na waɗannan ƙananan ƙwayoyin na iya taimakawa wajen kawar da bayyanar cututtuka.
Abinci & Ƙari ga GABA / Glutamate Function
Abubuwan da za a yi don sauya aikin GABA da glutamate a cikin kwakwalwarku ba a yi nazarin musamman ga FMS da ME / CFS ba, amma muna da wasu sani game da su.
Wani samfuri na GABA yana samuwa a matsayin kari. Duk da haka, ra'ayin likita na yanzu shi ne cewa ba ya haye ginin ƙwararrun jini (BBB) kuma saboda haka ba shi da wani abu don gyara rashin daidaituwa ta neurotransmitter.
Babu shakka, ƙila za ku iya ƙara samar da kayan GABA ta hanyar kara yawan abinci, tun da jikinku yana amfani da glutamate don samar da GABA.
Don ƙara samar da glutamate, zai iya taimakawa wajen ƙara ƙaddarar glutamate (abubuwan da jikinka yake amfani dasu) don cin abinci ko kariyar tsarin.
Wasu ƙaddara sun haɗa da:
- 5-HTP : jikinka ya canza 5-HTP zuwa serotonin, kuma serotonin zai iya inganta aikin GABA. 5-HTP wani nau'i ne na rukuni wanda aka samo a turkey. Duk da haka, tushen tushen abinci na kayan aiki ba a zaton su wuce BBB yadda 5-HTP ya yi.
- Glutamine: jikinka ya canza wannan amino acids zuwa cikin ruwa. Glutamine yana samuwa a cikin nau'in kari kuma yana cikin nama, kifi, qwai, kiwo, alkama da wasu kayan lambu.
- Taurin: An nuna amino acid din a cikin rodents don canza matakan kwakwalwa na GABA da glutamate. Zaka iya ɗaukar shi a cikin nauyin kari kuma ya samu ta jiki cikin nama da cin abincin teku. Ana ƙara yawan karfin Taurin zuwa abincin makamashi.
- Theanine : Wannan ƙaddarar glutamate ya nuna ya rage aiki mara kyau a cikin kwakwalwa ta hanyar hana masu karɓa yayin da yake karfafa matakan GABA. An samo ta a hakika a shayi kuma yana samuwa a matsayin kari.
Wata kwayar da ake kira Lactobacillus rhamnosus na iya canza aikin GABA a kwakwalwarka, bisa ga bincike na 2011. Masu bincike sunce 'yan mice wadanda suka ci kwayoyin suna da matsanancin matsala lokacin da aka sanya su a cikin yanayi masu wahala. Duk da haka, wannan yana buƙatar karin bincike kafin ya zama shawarwarin.
Kafin ka fara sabon kari ko yin canji mai mahimmanci, ka yi magana da likitanka da likitan magunguna game da hadarin gaske da hulɗar miyagun kwayoyi . Don bayani game da farawa kari, duba: 7 Abubuwa da kuke buƙatar Ku sani game da Karin kayan .
Drugs Wannan Alter GABA da Glutamate aiki a cikin Brain
Yawancin magunguna a halin yanzu a kasuwa sun canza aiki na kwakwalwa na GABA da glutamate.
Mutane da yawa sun gwada da / ko kuma sunyi amfani da su a matsayin jiyya na FMS, amma ba haka ba don ME / CFS.
Wadannan kwayoyi an kira agonists. Ba su sa matakan neurotransmitter su tashi ba amma maimakon ƙara yawan aiki ta hanyar karɓar masu karɓa. A gaskiya, sun sa kwakwalwarka ta yi amfani da abin da ke riga ya kasance.
GABA agonists sun hada da:
- Benzodiazepines: Wadannan kwayoyi suna raunana tsarin kulawa na tsakiya. Sauran maganin benzodiazepines sun hada da Ativan (lorazepam), Klonopin (clonazepam), Valium (diazepam) da Xanax (alprazolam). Ana sanya wa Benzodiazepines wasu lokuta wajabta ga FMS, musamman ma lokacin da rashin barci da damuwa sun kasance.
- Xyrem (sodium oxybate) & GHB (Gamma-Hydroxybutyric acid): Wadannan magungunan sun hada da magungunan ƙwayar cuta. GHB ta sunan titin ita ce " likitan fyade ". Xyrem an yarda da wasu alamun cututtuka na narcolepsy, kuma binciken ya nuna cewa yana da tasiri a matsayin magani na FMS; duk da haka, Cibiyar Abinci da Harkokin Kiwon Lafiyar Amurka (FDA) ta ƙi shi don FMS kan abubuwan da suka shafi tsaro.
- Magungunan marasa lafiya na Nonz-Benzodiazepine: Wannan magungunan magani yana kunshe da magungunan barci masu mahimmanci Ambien (zolpidem), Sonata (zaleplon) da Lunesta (eszopiclone). Wadannan kwayoyi suna da bambanci daga benzodiazepines amma suna aiki kamar wancan. Wasu nazarin (ciki har da Gronblad da Moldofsky, a kasa) sun nuna cewa wannan nau'i na magunguna na iya inganta barci da yiwuwar ciwo a FMS. Babu wani daga cikin wadannan kwayoyi da suka wuce gaban FDA don amincewa.
Shin yoga zai iya inganta GABA?
Yoga an yarda da yoga kullum. Shin zai iya ƙara GABA a kwakwalwa? Ɗaya daga cikin karamin binciken yana nuna cewa zai yiwu. Masu bincike sun bayar da rahoton cewa, kashi 27, cikin 100, na tasowa ne, a matsakaicin yoga GABA, a cikin takwas masu aikin.
Wannan kawai bincike guda ne, duk da haka, muna buƙatar ci gaba da bincike kan yoga koyon GABA kwakwalwa kuma ko ya aikata fiye da irin ayyukan.
Neurotransmitter Dysregulation
Idan kun yi imani kuna da GABA / glutamate dysregulation, ya kamata ku yi magana da likitanku game da zaɓuɓɓukan magani. Ka tuna cewa ko da magunguna na iya samun mummunan sakamako.
Karin bayani:
Sources:
Bravo JA, et. al. Ayyukan makarantun kimiyya na kasa na Amurka na Amurka. 2011 Zabi 20, 108 (38): 16050-5. Rashin maganin raunin Lactobacillus yana jagorancin halayyar motsa jiki da kuma jawabi na GABA mai karɓa a cikin wani linzamin kwamfuta ta hanyar jijiyar naman.
Jacobs GE, et. al. Ci gaba a cikin neuro-psychpharmacology da kuma nazarin halittu psychiatry. 2010 Apr 16; 34 (3): 486-91. Tsarin hypothalamic glutamate bayan matakan serotonergic.
Malemud CJ. Clinical da gwaji rheumatology. 2009 Sep-Oct; 27 (5 Sada 56): S86-91. Tallafawa ga tsarin cututtuka da magani na maganin cutar fibromyalgia.
Molchanova SM, Oja SS, Saransaari P. Ayyuka na yammacin masana'antun cinikayya. 2007; 50: 95-7. Halin taurin a kan hawan glutamate, GABA, glutamine da alanine a cikin rat striatum da hippocampus.
Spitzer AR, Broadman M. Pain Practice. 2010 Janairu, 10 (1): 54-9. Jiyya na rashin barci na narcoleptform a cikin ciwo mai wuya da kuma fibromyalgia tare da sodium oxybate.