Fahimtar Fibromyalgia da ME / CFS Drugs
Lokacin da kake koyi game da zafin maganin fibromyalgia da ciwo na gajiya mai tsanani , za ka iya zuwa fadin kalmar nan "masu tsaikowa". Ya bayyana irin nau'in antidepressant wanda aka saba wa dasu, ciki har da magungunan fibromyalgia na FDA da aka amince da su na FDA wato Cymbalta (duloxetine) da Savella (milnacipran) .
Amma ka fahimci abin da ake nufi da reuptake?
A lokacin da ka fara fara koyo game da magunguna, za a iya rikicewa-mun san wadannan yanayi sunyi la'akari da ƙananan ƙwayoyin siginar ƙwayoyin ƙwayar cuta da kewayo da kuma maipinepine, don haka dauki wani abu da zai hana su sauti.
Ƙarin bayani game da wannan ya haɗa da maganganun maganin likita wanda yawancin mu ba zasu fahimta ba. Da ke ƙasa, za ku sami raunin wannan tsari a cikin harshe wanda ya fi sauki don ganewa.
Menene Sake Gyara?
Na farko, kadan game da yadda kwakwalwarka ke aiki:
Kwayoyin kwakwalwarka (ragami) an rabu da kananan rabuwa. Lokacin da kwakwalwarka tana watsa saƙonni daga wani neuron zuwa wani, sai ya haɗi waɗannan ɓangaren ta hanyar watsar da sunadarai na musamman da ake kira neurotransmitters don ɗaukar sakon.
Bayan dan lokaci, sararin samaniya yayi kama da yawancin masu amfani da neurotransmitters. Yana da kama kamar bude adireshinku kuma ya ƙare tare da ɓoyayyen ruɗaɗɗen kwanto-waxannan envelopes suna da muhimmanci don samun wasikar zuwa gare ku, amma ba ku daina bukatar su.
Kwajinka yana tsaftace rikici ta hanyar tayar da mahaɗar da ke tattare da neurotransmitters don haka za'a iya sake sake su. Lokacin da aka ba da izini don magance shi.
Yanzu bari mu sauƙaƙe shi kuma mu ci gaba da mataki:
Ka yi tunanin gizo-gizo wanda yake a bayan ɗakin dakuna. Yana so ya shiga teburin, don haka ya harbe wani shafin yanar gizo a fadin rata.
Ya kamata ba shi da wata matsala da zai isa wurinsa, amma mai zubar da jini a cikin dakin yana juya wannan shugabanci kuma yana motsa shafin yanar gizo kafin gizo-gizo ya iya kammala tafiya.
Yanzu, yi tunanin cewa wani ya sake saurin gudu a kan fan don haka ya kara da hankali sosai. Wannan ya ba gizo-gizo ya isa lokacin da za ta haye rata kafin a cire shafin yanar gizon.
A gizo-gizo ne sakon, yanar gizo ne mai neurotransmitter, kuma fan ne reuptake. Lokacin da ka jinkirta reuptake, saƙo yana da isasshen mai amfani da neurotransmitter don samun inda yake faruwa. Masu maganin sake yin amfani da su ba su kara yawan adadin neurotransmitter a cikin kwakwalwarku ba, amma suna ƙara yawan lokaci yana samuwa. Wannan yana taimakon saƙonni inda suke zuwa.
Ta yaya Reuptake yake Neman Mu?
Masu bincike sunyi tunanin cewa jinin mutanen da ke da fibromyalgia, ciwo mai tsanani da ciwo, da kuma sauran cututtukan da ba su da lafiya ba su da matsanancin matakan wasu ƙananan magunguna ko kuma ba su amfani da su ne kawai ba. Wannan shine ake kira dysregulation neurotransmitter, kuma an yi imanin cewa yana da alhakin da yawa daga cikin alamunmu, ciki har da ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwayar cuta .
Binciken ya nuna cewa rage jinkirin reuptake yana taimakawa wajen farfado da bayyanar cututtuka a yawancin mutane da wadannan cututtuka.
Mazan tsofaffi masu tayar da hankali sun jinkirta aiwatar da dukkanin masu amfani da layi, wanda ya haifar da abubuwa da yawa maras so. Magunguna masu amfani da zamani sunyi amfani da wasu ƙananan kwastam ɗin musamman-musamman serotonin da norepinephrine. An kira su:
- Maɗaukaki masu sukar maganin serotonin (SSRIs)
- Serotonin-norepinephrine reuptake inhibitors (SNRIs)
Duk da yake wadannan kwayoyi suna haifar da matsalolin matsaloli fiye da magungunan tsofaffin magunguna, har yanzu suna da jerin jerin abubuwan da ke faruwa. Wani ɓangare na matsalar shi ne cewa ba mu da lalacewar neurotransmitter a kowane bangare na kwakwalwa, don haka magani zai iya inganta watsawa a wani yanki yayin yada shi a wani.
Duk da haka, sabon nau'i na SSRI yana fitowa wanda zai iya samar da taimako tare da ƙananan illa masu illa ta hanyar ƙaddamar da ƙwayar kwakwalwar da ta karɓa saƙon sakonni. Ana kiran wannan tantanin mai karɓa, kuma an shirya kowane mai karɓar don karɓar saƙonnin da wasu masu neurotransmitters suka aika. Mafi mahimmanci, mai karɓa shine ƙulle. Sai kawai maɓallan maɓallin ƙwayoyi na iya bude shi.
Wannan sabon miyagun ƙwayoyi yana amfani da maɓallin sunadarai da aka gwada don tayar da wasu masu karɓar sakonni a bude, yana sa sauƙaƙe don sakonni ya gudana daga tantanin halitta zuwa tantanin halitta. Akalla magani guda ɗaya irin wannan-Viibryd (vilazodone) - an yarda da shi a halin yanzu a ciki a Amurka. (Duk da haka, ba a bincike shi ba ko dai fibromyalgia ko ciwo mai wuya.)
Ƙara koyo game da yadda waɗannan kwayoyi ke aiki don yanayin mu:
Don ganin bayyanar cututtuka da ke da nasaba da lalacewar neurotransmitter, tare da zaɓuɓɓukan magani, karanta:
Sources:
Fields, R. Douglas, Ph.D. (2009) Sauran Brain. New York: Simon & Schuster.
Goldstein, J. Alasbimn Journal2 (7): Afrilu 2000. AJ07-5. "Tsarin Harkokin Kwafi da Kulawa da Ciwo na Ciwo da Raunin Dawa da Sauran Ƙwayoyin Tashin Lafiya: Ciwon Ilimi a cikin kwaya."
Smith AK, et al. Psychoneuroendocrinology. 2008 Feb, 33 (2): 188-97. "Tsarin kwayoyin gwagwarmaya na tsarin tsararraki a cikin ciwo mai wuya."
Jami'ar Kimiyya ta Maryland ta 2008. Duk haƙƙoƙin haƙƙin mallaka. "Ciwon daji na zamanin da"