Differences tsakanin PPIs da H2 Blockers for Heartburn

by Sharon Gillson; Binciken by Emmy Ludwig, MD

Kwatanta manyan nau'o'in likita biyu na GERD

Idan kuna da ƙwannafi, zamuyi mamakin bambanci tsakanin magungunan magungunan da ake amfani dasu: proton pump inhibitors (PPIs) da H2 blockers. Dukansu suna kawar da gastric acid mugun. Su ne daban, duk da haka, a yadda suke yin wannan.

Duk da yake PPI sun rufe pumps a cikin ciki, H2 blockers aiki ta hanyar hana masu karbar histamine a cikin kwayoyin halitta masu amfani da kwayoyi cikin ciki.

Ƙara koyo game da bambance-bambance, yadda za su iya taimaka wa ƙwannafi, da kuma dalilin da yasa likitanku zai bada shawara akan juna.

Abin da ke sanya ƙwannafi da abin da ake bukata a bi da shi?

Ƙunƙashin ƙwannafi zai iya haifarwa ta hanyar yanayin da ke ci gaba da ciwo da cutar cututtuka gastroesophageal (GERD) . GERD yana faruwa ne lokacin da ruwa daga ciki ya koma cikin esophagus. Kullum al'amuran ciki da sauran abubuwan da ke ciki sun kasance a cikin ciki (kuma daga cikin esophagus) ta hanyar bawul din da ake kira labaran ƙwayar halitta (LES). Amma abubuwa da yawa zasu iya raunana wannan asalin ciki har da:

Cin abinci wanda yakan haifar da ƙwannafi , irin su abinci acidic (alal misali, tumatir da 'ya'yan itatuwa citrus), kayan abinci na yaji, ko cakulan
Shan shan barasa ko maganin kafeyin
Shan taba taba
Samun wasu likita, irin su ciwon sukari da kuma asma
Samun ƙarin matsa lamba a kan ƙwayarka (alal misali, kiba, ciki, ko tsalle-tsalle)

Gyara gyaran gyare-gyare - gyaran shan taba, cutarwa da barasa da abincin da ke haifar da ƙwannafi, da kuma rasa nauyi - sau da yawa ne na farko na magani don ƙwannafi.

Amma wasu lokuta magani yana da bukata, kuma wannan shi ne inda PPI da H2 blockers zasu iya taimakawa.

Proton Pump Masu Haramtacciyar (PPIs)

Tsarin proton ya zama kwayoyin a cikin wasu kwayoyin jikinsu. Yana "pumps" acid a cikin ciki. Yana daukan wani potassium non potassium acid daga cikin ciki kuma ya maye gurbin shi tare da acidic hydrogen ion.

Wannan hydrogen ion shine abin da ke sa abubuwa su zama acidic. Ta hanyar saka ƙarin ions a cikin ciki, da famfar ya sa abinda ke cikin ciki yafi acidic. Amma ta wurin dakatar da aikin aikin famfo (hana shi), ƙwayar abu mai guba cikin ciki ta tsaya.

Ana amfani da masu hana kwantar da hanzari don magance GERD, ciwon ciki da duodenal ulcers , marasa lafiya mai yaduwa da kuma rashin lafiya na Zollinger-Ellison . Ana iya amfani da PPI kadai ko a ɗauka tare da haɗari. Dukkan PPI suna kama da yadda suke aiki, kuma babu wani shaidar da ya nuna daya ya fi tasiri fiye da wani. Duk da haka, sun bambanta da yadda hanta suka rushe su da yadda suke hulɗa da wasu magunguna. Bugu da ƙari, sakamakon wasu PPI na iya wucewa fiye da wasu kuma ana iya ɗaukar su akai-akai.

Sannan sun hada da:

Aciphex (rabeprazole)
Nexium (esomeprazole)
Prevacid (lansoprazole)
Prilosec (omeprazole) : Har ila yau yana samuwa a cikin over-the-counter kamar Prilosec OTC
Protonix (damuwa)
Dexilant (Dexlansoprazole)

PPI suna da jinkirin fara aiki yayin da H2 masu shinge fara aiki a cikin awa daya. Hakan na aiki na tsawon lokaci: mafi yawan har zuwa sa'o'i 24, kuma sakamakon zai iya zama har zuwa kwanaki 3. H2 blockers, duk da haka, yawanci kawai aiki har zuwa 12 hours.

H2 Blockers

Kwayoyin kwakwalwa a cikin rufin jikinka suna shawo kan hanyoyi da yawa don samar da acid.

Ɗaya daga cikin wadannan sunadarai na acidamine shine histamine, wanda ya danganta ga masu sauraron histamine 2 a kan tantanin halitta. H2 masu sintiri, gaskiya ga sunansu, toshe wadannan tashoshin masu karɓa kuma sabili da haka rage samar da acid.

H2 blockers sun hada da:

Ta Yaya H2 Blockers Ya Sauya daga Masu Rigar Fitilar Proton (PPIs)?

Kodayake duka masu safarar H2 da proton pump inhibitors duka suna kawar da gurguntaccen kwayoyi, akwai hanyoyi da yawa wadanda wadannan magunguna suka bambanta:

Yadda suke aiki: Suna aiki a matakai daban-daban na samar da ruwa mai ciki. H2 masu tayarwa (histamine blockers) toshe ɗaya daga cikin magunguna na farko don samar da acid. Masu kwantar da hanzari na kwantar da hankali sun kaddamar da mataki na karshe a cikin hanya na ɓoyewar acid a cikin ciki. A wasu kalmomi, acid wanda aka samo (wanda za'a iya ragewa saboda H2 blocker) an hana shi daga ciki.

A ina suke aiki: Dukansu magungunan wadannan magungunan ke aiki a cikin kwayoyin halitta, wanda shine kwayoyin halitta dake samar da acid a cikin rufin ciki. H2 masu shinge suna aiki ta hanyar hana masu karbawan histamine a cikin kwayoyin halitta don rage yawan adadin acid da aka samar (ko da yake akwai wasu matsalolin da za'a iya samar da acid). Masu kwantar da hankalin kwantar da hanzari suna aiki ta hanyar kulle ƙwayar proton a wadannan kwayoyin kuma suna hana acid daga ɓoye cikin ciki.
Yayinda suke aiki: Masu kwantar da hanzari na Proton sun haifar da matsananciyar maye gurbin acid fiye da H2 blockers. Wannan shi ne saboda akwai wasu matsalolin, banda tarihin 2, wanda ke motsa samar da acid da H2 masu shinge kawai toshe histamine 2.
Yaya da sannu suke aiki: H2 blockers suna da saurin aiki, sau da yawa aiki a cikin sa'a daya shan shan magani. Masu kwantar da hankalin kwantar da hanzari, da bambanci, suna da jinkirin fara aiki.
Yaya tsawon lokacin da suka wuce: H2 masu shinge na iya zama tasiri na tsawon sa'o'i 12 bayan shan magani. Masu kwantar da hanzari na kwantar da hankali sun fi tsayi. Wasu PPI na karshe har zuwa sa'o'i 24, yayin da wasu na iya samun tasiri wanda ya wuce kwanaki uku.
Sakamakon sakamako: Dangane da hanyoyin daban-daban na aikin, sakamakon ilimin likitanci na biyu sun bambanta da juna, duk da cewa ana amfani da su duka iri biyu. Abubuwan da za su iya yiwuwa sun haifar da bambancin tsakanin magungunan magunguna a kowannensu. Tare da H2 blockers, ciwon kai ya fi na kowa. Masu kwantar da hanzari na kwantar da hankali suna da lafiya sosai amma suna hade (a wasu nazarin amma ba duka ba) tare da haɗarin haɗari na ɓarna . Akwai wasu sakamako masu illa, kuma yana da muhimmanci mu tattauna wadannan tare da likitanku kafin amfani da waɗannan magunguna.

Menene Yaya Akwai H2 Blockers da PPI An Yi amfani da su?

Yana da kyau a san cewa baya ga ƙwannafi (kuma musamman musamman, GERD), ana amfani da waɗannan magunguna don bi da ka'idoji da kuma rage cututtuka na cututtuka na cututtukan fata . Ana iya amfani da su don magance wasu cututtuka masu narkewa wanda zai iya haifar da ƙananan ciki.

Zaɓan tsakanin H2 Blockers da Proton Pump Inhibitors

Kuna iya mamaki dalilin da yasa likitanku zai zabi daya daga waɗannan magunguna a kan wani. Tun da masu haɓaka kwalliyar proton sun samar da yawan maganin cututtukan acid, waɗannan ana buƙatar don ƙarin alamun bayyanar cututtuka.

Lokaci na farkon aikin zai iya ƙayyade abin da magani likitanku zai bada shawara. Tun da masu hawan H2 suna aiki a hanzari, ana amfani da su lokacin da mutum yana da fuka-fukansu na bayyanar cututtuka. Saboda wannan mataki mai sauri, ana iya amfani da waɗannan magunguna ga wadanda ke da ƙwannafi kawai.

Tun lokacin da masu hana kwashe-kwandar fitinar suka dauki tsawon lokaci don fara aiki amma suna da sakamako mafi girma, ana amfani da su sau da yawa ga wadanda ke da alamun ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar zuciya don samun iko akan bayyanar cututtuka.

Idan an gano ku a kwanan nan tare da GERD, yi magana da likitanku game da shirin kulawa. Idan ba ku sami sauki tare da sauye-sauye na rayuwa, za a iya ba da shawarar yin gwaji na mako takwas na PPI.

Idan kun ci gaba da samun alamun bayyanarwa bayan an dakatar da farfesa na PPI ko kuma idan kuna da rikitarwa daga GERD (kamar ƙwararraya masu tsauraran zuciya), kiyayewa (tsayi tsawon lokaci) Ana iya tsara magani na PPI. Wani lokaci H2-blocker, maimakon PPI, an bada shawarar don farfadowa.

Dokar vs. Magunguna masu ƙwayar cuta

Yawancin magunguna da aka yi amfani da ƙwayar ƙwannafi suna samuwa a matsayin takardun magani kuma a matsayin magungunan over-the-counter. Kodayake magungunan sun kasance iri ɗaya, magungunan magungunan ƙwayoyin magunguna suna samuwa a rageccen kashi (sau ɗaya da rabi na takardar sayan magani).

Yi magana da likitan ku ko likitan magunguna kafin ku sauya ɗaya daga cikin waɗannan. Har ila yau, ka kasance da sanin abubuwan da za su iya haifar da haɗari. Suna iya rage shafan wasu magunguna, ciki har da wasu magunguna.

Wasu Jiyya ga ƙwannafi

Bugu da ƙari ga masu haɗari H2 da kuma masu kwantar da hanzari na proton, mutane da yawa suna amfani da maganin da zasu taimaka wajen sarrafa ƙwayar ƙwannafi. Ka tuna cewa akwai bambancin tsakanin mutum da kuma magance likita game da wanene daga cikin wadannan magunguna zasu fi kyau a gare ka. Baya ga magunguna da kuma canje-canje na rayuwa, wasu mutane suna buƙatar ƙarin jiyya, irin su tiyata don hernias .

Bayan Magunguna don Heartburn

Tare da dukkan magungunan da ke akwai don magance ƙwannafin ƙwayar ƙwannafi, zamu manta game da sauye-sauye na rayuwa wanda zai taimaka wa ƙwannafi . Idan kana buƙatar magunguna don sarrafa ƙwannafinka, tabbatar da ganin ko wasu daga cikin wadannan matakan zasu iya inganta alamar alamarku:

Tsaya shan taba. Cigarette shan taba yana kaiwa zuwa ƙwannafi a hanyoyi da yawa.
Dubi abincinku. Sanar da abincin da zai sa ƙwannafi ya fi muni, da kuma abincin da ke da kyau ga mutane da ƙwannafi .
Rage rage cin abincin ku. Shan shan iya haifar da ƙwannafi ga wasu mutane.

Kalma Daga

Idan kana da tambayoyi game da shan magani na ƙwannafi, don Allah magana da likitanka. Har ila yau, yana da muhimmanci a dauki magani naka kamar yadda aka tsara, ciki har da bin adadin daidai da lokaci na cin abinci. Tare da magani, dubi hanyoyin da za ku iya canza salon salon rayuwa wanda zai rage ƙwannafin ku.

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> Scarpignato C, Gatta L, Zullo A, Blandizzi C. Kwayoyin Cutar Tsuntsauran Tsaro da Tsaro Mai Sauƙin Kwayoyin Cutar Abun Cutar-Rubutun Matsayi Suna Magana da Amfanin da Damuwar Maganganin Tsarin Abidin. BMC Medicine . An wallafa shi a layi 2016 Nov 9.

> Shin JM, Kim N. > Pharmacokinetics > da kuma Pharmacodynamics na Masu Tsaro na Proton Pump. Jaridar Neurogastroenterology da Motility . 2013; 19 (1): 25-35. Doi: 10.5056 / jnm.2013.19.1.25.

Zhang Y, Qing L, He B, Liu R, Zuo-Jing L. Proton Pump Ma'aikatan Inhibitors vs H2 Receptor Antagonists Farida na Upper Gastrointestinal Bleeding Bayan Endoscopy: A Meta-Analysis. Jaridar Duniya na Gastroenterology . 2015. 21 (20): 6341-6351.