Amfani da dogon lokacin da ake dangantawa da cututtuka masu tsanani
Masu kwantar da hanzari na Proton (PPIs) sune rukuni na kwayoyi wanda shine manufar rage yawan ciki. An yi amfani da su don magance cututtuka masu kama da ganyayyaki da suka shafi kimanin shekaru 20 kuma an san su da lafiya da tasiri-saboda haka sun fi mayar da magungunan H2 a matsayin magani na zabi.
Wannan ba shine a ce PPI ba ba tare da kalubale ko ƙuntatawa ba.
Yayinda yawancin abubuwan da ke cikin tasiri sun kasance masu sauki kuma suna iya yin amfani da su, akwai abubuwa da dama waɗanda zasu iya faruwa tare da amfani da tsawon lokaci ko yin amfani da su. Wadannan sun haɗa da matsalolin da ake amfani da ma'adanai, canje-canje a cikin ƙananan kashi, da kuma kara haɗari ga wasu cututtuka na kullum.
Ta yaya Proton Pump Inhibitors Work?
Ana amfani dasu masu kwantar da hanzari don magance cututtuka irin su cututtukan gastroesophageal (GERD) , cututtuka na fata , da kuma marasa galibi , likitoci na iya yin amfani da ita ta amfani da PPI kadai ko a hade tare da maganin cutar. Ana iya amfani da su tare da wasu maganin rigakafi a lokacin da ake kula da Helicobacter pylori (kwayoyin da ke hade da ciwon ciki na ciki).
PPI suna aiki ne ta hanyar daurin kwayar halitta akan bango na cikin ciki wanda ake kira cell sallar wanda shine dalilin samar da hydrochloric acid (HCL). Ta hanyar yin haka, ciki baya iya ɓoye HCL, yana barin ulcers don warkarwa da sakewa don ragewa.
Hanyoyin PPI sun bambanta da H2 blockers a cikin wannan PPI rufe kullun acid yayin da H2 blockers kawai toshe siginar da ke haifar da samar da acid. Saboda wannan, PPI na aiki har zuwa awa 24 da kuma samar da taimako ga 72 hours. H2 blockers, ta bambanta, aiki na tsawon sa'o'i 12.
Daban Proton Pump Masu Haramtacciyar
Kullum magana, daya PPI ba ya bambanta wannan abu da yawa daga wasu.
Dukkanansu suna da irin wannan aikin da aka yi da kuma irin wannan tasiri na tasiri. A halin yanzu an amince da sunayen PPI:
- Prilosec (omeprazole)
- Prevacid (lansoprazole)
- Protonix (damuwa)
- Aciphex (rabeprazole)
- Nexium (esomeprazole)
- Dexilant (dexlansoprazole)
Duk da kamantarsu, wasu kamfanonin PPI suna ganin sun fi tasiri wajen magance wasu yanayi. Alal misali, Dexilant da Protonix ba a saba amfani dasu ba don magance cutar ta H. pylori ; wasu suna. Domin tallafin ƙwaƙwalwar ƙwayar zuciya, Prilosec da Prevacid suna bada shawarar inda ba sauran. Saboda haka, yana da muhimmanci a yi magana da likita don tabbatar da cewa yin amfani da PPI ya dace.
Hanyoyin Yanayi da Harkokin Tattaunawa
Lokacin da aka ɗauki a kan gajeren lokaci, yawancin alamun da ke hade da PP! amfani ne m da m. Mafi yawan sun hada da maƙarƙashiya, cututtuka, flatulence, ciwon kai, ciwon ciki, tashin zuciya, da kuma zubar da ciki.
Ƙarin shaida yana nuna cewa yin amfani da dogon lokaci zai iya haifar da matsaloli masu tsanani. Tsakanin su:
- An ba da shawara cewa amfani da PPI zai iya tsangwama tare da ɗaukar alli, wanda zai haifar da fractures kashi a wasu lokuta. A cikin martani, Cibiyar Abinci da Drugta ta Amurka ta ba da gargadi a shekara ta 2011 yana nuna cewa za a yi amfani da PPI a kan magunguna fiye da makonni biyu a lokaci guda har zuwa uku jiyya a kowace shekara.
- An yi amfani da PPI na tsawon lokacin da aka haɗuwa da ƙananan ƙananan haɗari na ciwon huhu da ƙananan kamuwa da Clostridium .
- Nazarin ya nuna cewa amfani da PPI fiye da shekaru 10 yana da raunin kashi 12.5 cikin dari na bunkasa cutar koda, dan kadan ya fi karuwar kashi 8.5 cikin yawan jama'a.
- Wani bincike mai kama da ya nuna cewa mutanen da suka dauki nauyin PPI fiye da shekaru bakwai sun sami damar kashi 13 cikin dari na samun damuwa idan aka kwatanta da waɗanda basu yi hakan ba.
Yawancin wadannan cututtuka masu haɗari sun haɗu da gaskiyar cewa PPI ba wai kawai kashe kullun acid ba a ciki amma cikin sauran jiki, kazalika.
Wannan ya haɗa da ɓangaren kwayar halitta da ake kira lysosome wanda yake amfani da acid don share sharar gida. Ba tare da hanyar yin haka ba, sharar gida zai iya tarawa kuma ya sa tantanin halitta ya taso da kuma shekaru. Wannan sabon abu na iya ƙididdiga ga ƙimar da ake gani a cikin binciken.
Abubuwan da aka gano sun nuna gaskiyar cewa ana amfani da PPI kawai don tallafi na gajeren lokaci ko magani maimakon a matsayin hanyar da za a hana cutar rashin lafiya a cikin dogon lokaci.
> Source
- > Jacob Schoenfeld, J. da Grady, D. "Harkokin Cutar da Aka Rarraba Masu Rashin Gyara ta Proton." Jaridar Ƙungiyar lafiya ta Amirka. 2016: 176 (2): 172-174.