Drug yana hana HIV daga Kashe Kayan Kwayoyin Halitta na Cell
Ƙayyadewa
Vitekta (elvitegravir) wani maganin rigakafi ne wanda aka tsara a matsayin mai hadewa wanda ke amfani da shi wajen maganin HIV . Haɗaka masu hana masu hanawa ta hanyar hana kwayar cutar HIV wadda ake kira hadewa, wanda HIV ke amfani da shi wajen hadewa cikin tsarin halittar kwayoyin halittar DNA. Ta hanyar hana haɗin ciki, kwayar cutar bata iya cika rayuwan rayuwa ba kuma haifar da wasu kwayoyin cutar HIV.
Cibiyar Abinci da Drug ta Amurka (FDA) ta amince da Vitekta a cikin watan Satumbar 2014 don amfani da manya a baya da aka nuna wa cutar HIV.
Elvitegravir wani ɓangare ne na maganin magunguna na Stribild (wanda aka fi sani da "Quad Pill") da kuma na biyu na Stribild da ake kira Genvoya .
Drug Formulation
Vitekta yana samuwa a cikin tsari biyu na kwamfutar hannu:
- Kwancen pentagon mai lamba 85 da aka yi da fim din, mai launin kore tare da "GSI" wanda aka saka a gefe ɗaya da "85" a daya.
- Gilashi mai kwakwalwa ta MG 150, mai launin fim, mai launin kore da launi tare da "GSI" wanda aka saka a gefe ɗaya da "150" a daya.
Yankewa
Dole ne a yi amfani da Vitekta a kowane lokaci tare da duka mai maganin HIV protease (PI) da Norvir (ritonavir) , wani wakili mai "bunkasa" wanda ya shimfiɗa ƙaddamar da magunguna a cikin jini. Dole ne a dauki Vitekta tare da abinci.
Yanayin da aka bayar da shawarar ya bambanta da zaɓi na miyagun ƙwayoyi kamar haka:
| Vitekta sashi | Magunin ƙwayar cuta mai tsaro | Norvir (ritonavir) sashi |
| 85mg sau ɗaya kowace rana | Reyataz (atazanavir) 300mg sau ɗaya kowace rana | 100mg sau daya a kowace rana |
| 85mg sau ɗaya kowace rana | Kaletra (400mg lopinavir + 100 mg ritonavir) sau biyu a kowace rana | Ba a buƙata a matsayin ritonavir an riga ya ƙunshi tsarin Kaletra ba |
| 150mg sau ɗaya kowace rana | Prezista (darunavir) 600mg sau biyu a kowace rana | 100mg sau biyu a kowace rana |
| 150mg sau ɗaya kowace rana | Lexiva (fosamprenavir) 700mg sau biyu a kowace rana | 100mg sau biyu a kowace rana |
| 150mg sau ɗaya kowace rana | Aptivus (tipranavir) 500mg sau biyu a kowace rana | 200mg sau biyu a kowace rana |
Hanyoyin Kasuwanci
A cikin binciken na asibiti na ɗan Adam na III, an gano magungunan maganin miyagun ƙwayoyi da dama a cikin marasa lafiya ɗauke da Vitekta. Abubuwan da suka fi dacewa, sun ruwaito a akalla 2% na mahalarta fitina sun hada da:
- Diarrhea
- Jiɗa
- Ciwon kai
Sakamakon sakamako mafi rinjaye sun hada da ciwo na ciki, rashin ciwo, raguwa, gajiya da vomiting. Saurin yanayi ya kasance mai saurin wucewa, tare da ƙananan marasa lafiya sun daina sakamakon rashin haƙuri.
Drug Contraindications
Ba za a dauka Vitekta ba tare da wasu kwayoyi masu amfani da su ko abubuwan da suka dace da ita:
- Hepatitis C magani: Invicek, Victrelis
- Magunguna masu maganin tarin fuka-fuka na Rifampin: Rifater, Rifamate, Rimactane, Rifadin, Priftin (musanya da Mycobutin)
- St. John's Wort
Koyaushe sanar da likitanka game da duk wani magani ko kari, wanda aka tsara ko ba a ba shi ba, wanda za ka iya ɗauka kafin ka fara wani maganin antiretroviral.
Hanyoyin Intanet na Harkokin Drug
Yin amfani da Vitekta tare da bin magungunan antiretroviral zai iya haifar da ko dai a cikin asarar sakamakon warkewar miyagun ƙwayoyi ko ƙarin haɓakar sakamako:
- Sustiva (efavirenz) bai kamata a rika sarrafa shi tare da Vitetkta ba.
- Viramune (nevirapine) ba za a yi amfani da shi tare da Vitekta ba.
- Videx (didanosine) ya kamata a dauki sa'a ɗaya kafin ko sa'o'i biyu bayan wani Vitekta.
- Tsinkaya (cobicistat), wani wakili mai karfi kamar Norvir, bai kamata a dauki shi tare da Vitekta ba lokacin da aka yi nazari tare da mai hana protease.
Sauran Bayanai
Antacids zai iya hana Vitekta daga hankali. Idan kana yin amfani da antacid na counter-counter (misali Rolaids, Tums, Milk of Magnesia), an nuna cewa za'a dauki shi a cikin sa'o'i biyu kafin ko bayan bayanan Evotaz.
Mata suyi shawara ga likitan su idan suna daukar ko shirin tsara wasu kwayoyin maganin haihuwa. Vitekta, lokacin da aka yi amfani da Norvir, zai iya rage yawan ƙaddarar cutar plasma na haɓakar ɗaɗɗar hormonal ethinyl estradiol / morgus .
Ana amfani da hanyoyi dabam dabam na maganin hana haihuwa ba tare da hormonal ba. Kada ku ƙara yawan maganin maganin rigakafi na hormonal. An shawarci cewa mahaifiyar ba ta yin nono idan suna da kwayar cutar HIV kamar yadda zai iya watsa cutar zuwa jariri.
Vitekta yana dauke da lactose don haka tabbatar da shawarar likitan ku idan kun kasance marasa laushi.
Sources:
Cibiyar Abinci da Druggun Amurka (FDA). " VITEKTA - BAYAN GABATARWA." Silver Srpring, Maryland; isa ga Fabrairu 3, 2015.
FDA. "FDA ta amince da sababbin kwayar cutar HIV don maganin marasa lafiya." Silver Spring, Maryland; sanarwa da aka bayar a ranar 27 ga Agusta, 2012.
Kimiyya ta Gilead. " Genvoya - Karin Bayani na Bayani Bayani." Foster City, California; isa ga Disamba 14, 2015.