Genvoya daya takarda ne, mai amfani da maganin maganin cutar HIV, wanda ya hada da kwayoyi guda hudu daban-daban:
- Elvitegravir , mai hadewa mai shiga
- Cobicistat , wani kwayar cutar HIV "booster" miyagun ƙwayoyi
- Emtricitabine, mai maganin nufarotide baya mai hanawa (NtRTI)
- Tenofovir alafenamide (TAF), wani NtRTI
Genvoya shine nau'in haɗari na farko don amfani da TAF, wani fashewar "inganta" na tenofovir disoproxil fumarate (TDF) da aka gano a cikin kwayoyin Truvada, Atripla , da Ƙarshe.
Saboda haka, ana iya la'akari da ci gaba a kan Stribild , tsarin da aka kunshi guda ɗaya wanda ya hada da elvitegravir + cobicistat + emtricitabine + TDF.
TAF tana da daraja ga TDF domin yana iya ba da magani mafi dacewa a cikin kwayoyin halitta kuma a cikin ƙananan ƙwayoyi-ma'anar cewa akwai ƙananan gina ƙwayar miyagun ƙwayoyi a cikin jini da kuma rashin damar yin amfani da ƙwayar cuta. abubuwa masu guba.
(Yayin da ake la'akari da haɗarin cutar TDF a matsayin kasa a kasashe masu tasowa, ana ganin wannan hadarin ya tashi da yawa a kasashe masu tasowa inda akwai yiwuwar haddasa ciwon koda a yanzu.
Jiyya Kula
Hukumar Ciniki da Drug ta Amurka ta amince da Genvoya a ranar 5 ga watan Nuwamba, 2015, don amfani da duka yara da yara fiye da shekaru 12 wadanda ba su taba yin maganin cutar kanjamau ba kuma suna kimanin kilo 77 (35 kgs). Haka kuma an yarda da manya kan farfesa wanda ke da nauyin nauyin hoto (undetectable).
Halitta
Genvoya wani kore ne, oblong, kwamfutar hannu mai launi, ya hada da 150mg na elvitegravir, 150mg na cobicistat, 200mg na emtricitabine da 10mg na TAF. An sanya shi da "GSI" a gefe ɗaya kuma tare da "510" a daya.
Yankewa
Ana amfani da kwamfutar hannu kowace rana tare da abinci. Kada a dauka Genvoya tare da wani maganin rigakafi da ake amfani dasu don magance cutar ta HIV.
Hanyoyin Gaba
An gano wasu alamun maganin miyagun ƙwayoyi a cikin gwaji masu gwaji da ke dauke da Genvoya. Abubuwa mafi banbanci na yau da kullum, wadanda aka ruwaito cikin 5% ko fiye da marasa lafiya, sune:
- Jiɗa
- Diarrhea
- Wulo
- Ciwon kai
Hanyoyin da ke faruwa sun kasance da sauri, suna yin maganin makonni 1-2, tare da marasa lafiya da yawa sun daina sakamakon rashin haƙuri.
Contraindications
Kada a dauki Genvoya tare da wasu kwayoyi ko kariyoyi:
Magunguna masu magunguna: Cafergot, Migergot, Ergostat, Madina Ergotamine, Wigina, Wigrettes, Ergotrate, Methergine, DHE 45
- Anti-psychotic magani: Orap
- Cholesterol-lowering statin kwayoyi: Zocor, Simcor, Vytorin, Mevacor, Advicor, Altoprev, Mevacor
- Hepatitis B magani: Hepsera, Preveon
- Prokinetic jamiái: Propulsid, Propulsid Quicksolv
- Magungunan ƙasa: Uroxatral
- Magungunan hawan jini na jini: Revatio
- Magunguna masu tarin fuka: Mycobutin, Rifater, Rifamate, Rimactane, Rifadin, Priftin
- Sedatives: Versed, Halcion
- St. John's Wort
Sauran Bayanai
An ba da shawarar Genvoya ga marasa lafiya da rashin nauyin koda (wanda aka kiyasta yana da kimanin ƙirar mahaifa akan kasa da 30mL a minti daya). Don Allah a ba da shawara ga likitanku idan an kasance ko an kula da ku saboda kowace cuta ta koda ta wani likita.
An ba da shawarar Genvoya ga marasa lafiya da rashin hanta ko kuma wadanda ke fama da ciwon hawan B (HBV) na kullum kamar yadda zai iya haifar da matsalolin hanta. Ana ba da shawara cewa mutane da ke dauke da kwayar cutar ta HIV za su kula da HBV kafin su tsara Genvoya. Don Allah a shawarci likitan ku idan kuna da kowace matsalar hanta da / ko tarihin hepatitis.
Sources:
Cibiyar Abinci da Drug. "FDA ta amince da sabon maganin cutar HIV." Silver Spring, Maryland; latsa saki a ranar 5 ga Nuwamba, 2015.
Kimiyya ta Gilead. "Genvoya - Karin Bayani na Bayani Bayani." Foster City, California