Rage raguwa da aka hade da magungunan da ake amfani da su da kuma kari
Amfani da maganin miyagun ƙwayoyi sune damuwa ga kowa da ke dauke da kwayar cutar HIV da likitocin su, musamman idan mutum yana ganin wasu kwararrun likitoci na wasu, wadanda ba na HIV ba. Duk da yake ƙwayoyin magani na iya gano wadannan hulɗar a lokacin da aka cika rubutun, akwai samfurori na samfurori da zasu iya tashi a ƙarƙashin radar likitancin, kuma, idan aka karɓa, ƙananan ƙananan ƙwayar maganin magunguna (ARVs).
Zasu iya yin hakan ko ta hanyar tsangwama tare da shayar wasu ARV, ta hana ƙananan enzymes da ake bukata don maganin maganin miyagun ƙwayoyi, ko kuma haifar da ƙãra rashin buƙata ko rage yawan matakan magunguna na ARV. Abin mamaki, wasu daga cikin waɗannan samfurori ne a kowace rana, abubuwa masu yawa, yayin da wasu su ne takardun magani ko magungunan kwayoyi ba za ku yi tunanin sau biyu ba game da ɗaukar yanayi.
Idan kuna gab da fara maganin rigakafi , koyaushe tabbatar da bada shawara ga likitanku na kowane magani ko kari-ciki har da kayan lambu ko na gaba daya-za ku iya ɗauka. Idan kun rigaya a kan farfadowa kuma suna shan kowane samfurorin da aka biyo baya zuwa ka'idodi na ARV na musamman, kuyi magana da likitan ku. Hakanan zaka iya tattauna ko sake dawowa da lissafi na maganin maganin miyagun ƙwayoyi, dakatar da samfur contraindicated, ko sauya sigogi na ARV, idan an buƙata.
Tsare-tsaren Alkawari da Suspensions
Magnesium- da alkama masu dauke da kwayoyin (irin su Maalox, Mylanta, Milk na Magnesia, Tums) na iya warware ƙwayar ciki zuwa irin wannan digiri don yin tasiri sosai tare da ɗaukar wasu ARV.
Hakanan irin wannan zai haifar da kayyadadden kayyadadden kima don ɗan gajeren lokaci kuma za'a iya gudanar da su a cikin sa'oi biyu zuwa shida kafin ko bayan wani kashi.
Jirgin da ke dauke da wadannan kwayoyi sun hada da:
- Aptivus (tipranavir) - yi tsai da sa'o'i shida kafin ko sa'o'i biyu bayan haka
- Mai jagorantar (rilpivirine) - yi antacid sa'o'i biyu kafin ko hudu bayan haka
- Mai rikodin (delavirdine) - yi antacid sa'a daya kafin ko sa'o'i biyu bayan
- Stribild (elvitegravir + cobicistat + tenofovir + emtricitabine) -ace antacid sa'o'i biyu kafin ko bayan
- Tivicay (dolutegravir) - yi antacid sa'o'i shida kafin ko sa'o'i biyu bayan
- Triumeq (dolutegravir + ziagen + epivir) - ƙaddara a cikin sa'o'i shida kafin ko sa'o'i biyu
Sauran maganin cututtukan acid kamar prohibit pump inhibitors (misali, Nexium, Prilosec, Losec, Prevacid) suna da sakamako mai tsawo kuma zai iya rage rinjayar duka Reyataz (atazanavir) da kuma Edurant (rilpivirine) ta hanyar kimanin kashi 78 da 40 kashi, bi da bi. Saboda haka, ana amfani da amfani da masu kwantar da hankalin proton pump don amfani da wadannan ƙwararru na ARV musamman kuma kulawa ta musamman ya kamata a dauka lokacin amfani da masu karɓar mai karɓa na H2 irin su Tagamet da Zantac, kazalika.
Tuntuɓi likita don tattauna yadda za a canza dosing da / ko magunguna idan amfani da kowanne ko ko dai daga cikin wadannan magungunan miyagun ƙwayoyi tare da Reyataz ko Mai jagoranta.
St. John's Wort
Hypericum perforatum , wanda aka fi sani da shi a St John's Wort, wani tsire-tsire ne wanda wasu suka amince da cewa suna da anti-inflammatory, antiviral, antidepressant, da kuma mallakar antioxidant. Duk da yake babban maganin da aka gudanar a shekara ta 2008 ya nuna cewa maganin na ganye yana da amfani a wajen magance matsalolin babban ciki, sauran kamfanonin da aka ruwaito sun kasance a cikin gardama tare da hujjoji marasa rinjaye don tallafawa da yawa daga cikin da'awar.
Idan aka yi amfani da shi zuwa ga maganin antiretroviral, St. John's Wort na iya rinjayar aikin da ake ciki na CYP450 3A4, wanda ke aiki ta hanyar oxidizing kwayoyin miyagun ƙwayoyi domin su iya cire daga jiki. Idan wannan ya auku, za a iya rage yawan magungunan maganin magungunan maganin kwayar cutar ta HIV (PIs) da kuma wadanda basu da magungunan baya (NNRTIs) , wasu lokuta ta hanyar 82 bisa dari. Saboda haka, ba za a dauki St. John's Wort tare da ARV ba:
- Aptivus (tipranavir)
- Crixivan (indinavir)
- Mai jagorantar (rilpivirine)
- Halin (etravirine)
- Invirase (saquinavir)
- Kaletra (lopinavir + ritonavir)
- Lexiva (fosamprenavir)
- Norvir (ritonavir)
- Prezista (darunavir)
- Mawallafi (delavirdine)
- Reyataz (atazanavir)
- Sugar (wanda zai shafi ilimin elvitegravir da kwayoyi masu maganin maganin magunguna a haɗin hade)
- Sustiva (efavirenz) ko Atripla (wani hade mai haɗuwa da ya ƙunshi efavirenz)
- Tsarin zane (nelfinavir)
- Viramune (nevirapine)
Tafarnuwa
Wasu mutane sunyi gargajiya don samun kaddarorin da za su iya hana ko magance magunguna masu yawa, daga sanyi da cutar hawan jini zuwa cutar cututtukan zuciya da ciwon daji. Wasu hukumomi sun danganta waɗannan kaddarorin zuwa sinadaran da ke cikin tafarnuwa da ake kira allicin.
Duk da yake nazarin ya nuna alamun albarkatun tafarnuwa- ko dai a cikin foda, tsantsa, capsule, ko kuma kwamfutar hannu-akwai yiwuwar zubar da hankali lokacin da aka hade tare da kwayar kare lafiyar protease mai lamba Invirase (saquinavir). Ta hanyar tsangwama tare da CYP450 3A4 a cikin ƙuƙwalwa, kayan da ke cikin tafarnuwa zai iya rage yiwuwar rage yawan magungunan likitanci na Invirase na kimanin kashi 54. Koda bayan an gama amfani da tafarnuwa, nazarin ya nuna cewa sakamakon ci gaba zai iya ci gaba da kwanaki har ma makonni bayan.
Wasu nazarin sun nuna cewa tafarnuwa na iya shafar yiwuwar wasu nau'o'i da NNRTIs, ko da yake babu takamaiman takaddama don amfani da babu shawarwari game da nauyin ko wane nau'i na tafarnuwa (ciki har da raw) na iya dace ko bai dace ba. Saboda haka, idan kuna shan tafarnuwa a kowane nau'i a matsayin kariyar lafiyar jiki, an shawarce ku cewa ku bari likitanku ya san.
> Sources:
> Ma'aikatar Kiwon Lafiyar Jama'ar Amirka da Harkokin Dan Adam (DHHS). "Sharuɗɗa don Amfani da Ma'aikata marasa lafiya a HIV-1-Infected Adults and Adolescents." Washington, DC; Janairu 19, 2015.
> Linde, K .; Berner, M. da Kriston, L. "St John na wort ga babban ciki." Cochrane Database of Manyan Labarai . Oktoba 8, 2008; (4): CD000448. Doi: 10.1002 / 14651858.CD000448.pub3.
> Piscitelli, S .; Burstein, A .; Welden, N. et al. "Sakamakon saurin tafarnuwa a kan pharmacokinetics na saquinavir." Magunguna na cututtuka; 34 (2): 234-238.