Magunguna na Abun Yiwuwa Zai Yarda Ƙarƙashin Ƙarƙashin Ƙarƙashin Ƙarƙashin Neuro
Ambien (wanda aka sayar a matsayin zane-zane) yana yawanci wajabta don kula da rashin barci, amma zai iya taimaka wa sauran cututtuka na jiki kamar coma, jihohin ciyayi, dystonia, cutar Parkinson, bugun jini, lalata, da kuma cututtukan kwakwalwa na kwakwalwa? Rahotanni da ƙananan bincike suna ba da damar yiwuwar amfani, kuma wani bita ya karfafa nazari akan aikin shan magani a cikin farfadowa marasa lafiya.
Yaya Ambien aiki a kan Brain?
Zolpidem (sayar da Ambien, Ambien CR, da Intermezzo) sune maganin maganin maganin maganin magance kwayoyi wanda Hukumar Abinci da Drug ta amince da ita don kula da rashin barci . Yana da ingancin zaɓaɓɓu da abubuwa a kan irin I gamma aminobutyric acid A (GABA A) benzodiazepine receptor. Wannan na iya taimakawa wajen rage ayyukan da wasu wurare na kwakwalwa suke ciki, da inganta halin mutunci da kuma ragewa da hankali. Yana iya kara yawan karuwar barci ta REM ta hanyar rage aikin dopamine, sakamako wanda zai iya ƙara yawan matakan prolactin .
Ambien yana aiki da sauri, yana maida hankali a cikin jini bayan sa'o'i 1.6 na amfani. Ba shi da wani aiki na metabolites. A cikin ƙasa da 3 hours (tare da daidaitattun tsari ya kasance daga 1.5 zuwa 2.4 hours), matakan jini na Ambien sun rage ta rabi. Tsarin sarrafawa-saki (sayar da Ambien CR) yana da rabin rabi na 1.5 zuwa 4.5 hours.
Tsarin sararin samaniya yana wucewa a cikin fitsari ta hanyar kodan.
Kodayake taimakon gaggawa da aka fi sani dasu, Ambien na da ƙananan tasiri akan darajar barci. Lokacin da aka dauki nauyin MG 10, zai iya rage lokacin da ya kamata ya bar barci ta kawai kawai zuwa minti 5 zuwa 12, a matsakaita. Zai iya rage lokaci mai tsawo da aka farka a cikin dare ta karin minti 25.
Yaya zai iya tasiri wasu cututtukan da ke shafi kwakwalwa?
Ayyukan Ambien a Yin maganin Cutar Neurological
Masu bincike daga Jami'ar Michigan sun taƙaita jikin wallafe-wallafen kimiyya akan yadda zolpidem zai iya tasiri wasu yanayin da ke shafi kwakwalwa, ciki har da coma, dystonia, bugun jini, da kuma lalata. Wasu daga cikin binciken su na ƙarfafa wa waɗanda ke fama da mummunan rauni da lalacewa ga kwakwalwa.
Martin Bomalaski, MD, da abokan aikinsa sun sake nazarin 2314 articles da aka buga ta ranar 20 ga watan Maris, 2015. Bayan an sake nazarin abubuwanda aka rubuta, an sake nazarin cikakkun litattafai game da articles 67. Yawancin wadannan rahotanni sun haɗa da kananan gwaje-gwaje da kuma rahoton shari'ar, wanda ke wakiltar ƙananan shaida na asibiti. A gaskiya ma, kawai 11 daga cikin nazarin sun ƙunshi mahalarta 10. Akwai gwajin gwagwarmaya guda 9 kawai, wanda aka yi la'akari da tsarin zinare na bincike na asibiti. Wannan na iya tasiri fassarar sakamakon da yadda ake amfani da ita ga yawan mutane.
Akwai matsaloli masu yawa na matsalolin da aka gwada zolpidem:
- Raunin motsi (binciken 31) - dystonia da cutar Parkinson
- Rashin lafiya (22 nazarin) - coma da ci gaba vegetative jihar
- Sauran matsalolin neuro (14 nazarin) - bugun jini , traumatic kwakwalwa rauni, infirhalopathy, da kuma dementia
Masu bincike sun binciko abubuwan da aka tsara game da irin nau'o'in cuta da suka shafi, maganin zolpidem da aka yi amfani dasu, mita na dosing, lura da illa, da kuma cututtukan cututtuka masu tasiri.
Waɗanne Ayyukan Kwarewa An Yi Sanin Tare da Jiyya na Abis?
Akwai wasu alamomi da dama waɗanda aka tantance su, daga matsala suna magana (aphasia), rashin amsawa (rashin tausayawa), da kuma matsalolin motsi da ke haɗuwa da rashin haɗin kai. An yi amfani da martani sosai tare da wasu samfurori masu amfani da kwayar cutar da ake amfani dasu don maganin cutar, cutar Parkinson, dystonia, da sauran matsalolin.
Gaba ɗaya, zolpidem ya ba da taimako na gaggawa: yawancin cigaba, idan an kiyaye shi, yana da sa'a daya kawai zuwa hudu. Wadannan haɓakawa sun sake dawowa, suna buƙatar jinkirtawa saboda yawan gajeren rai na miyagun ƙwayoyi. An samu cigaban kayan aiki a cikin motar, maida hankali, da kuma damar iya magana. Wasu magungunan marasa lafiya ko marasa lafiya masu cin nama sun kara ingantaccen halin jiha, wasu ma sun yi kokari suyi magana.
Har ila yau, akwai nazarin da ya nuna cewa ingantaccen aikin neuroimaging, yana nuna wata canji mai haske a cikin ilmin halayen kwakwalwa da haɗin. Wadannan sakamako na musamman zasu iya kasancewa a cikin marasa lafiya wanda ke fama da rauni, wanda wani ɓangare na kwakwalwa wanda ke taimakawa wajen aiwatar da bayanai don daidaita tsarin da ake bukata ko amsawar motar.
Sakamakon sakamako kamar yadda za a iya tsammanin: zolpidem yana raguwa. Wannan zai iya haifar da barci kuma an ruwaito shi a cikin 13 daga cikin marasa lafiya 551 da suka yi kokarin. Tun da alamun bayyanar cututtuka suna nufin ingantawa a lokacin tashin hankali, wannan yana iya zama babban iyakance na amfani da magani. Yayin da ƙari ya shafi tasirin ƙwaƙwalwar ajiya, ana iya ɗauka cewa za'a iya tasiri akan ƙwaƙwalwar ƙwaƙwalwa . Yayin da mutanen da suka yi amfani da maganin na iya zama da mummunan haɓakawa a asali, za a iya jaddada cikakkiyar godiya game da illa mai lalacewa.
Abin takaici, zolpidem ba ya aiki ga kowa da kowa. A gaskiya ma, kashi 5 zuwa 7 cikin 100 na marasa lafiya da ke fama da cututtukan da ke fama da hankali sun mayar da martani ga miyagun ƙwayoyi. Wannan yana nufin cewa har zuwa kashi 95 na mutanen da suka yi amfani da shi ba su da matukar cigaba a jihohin su. Daga cikin wa] annan batutuwa da suka shafi halayen motsi, yawan da ake mayar da martani ya karu, ya kai kashi 24 cikin 100.
Mutane da yawa basu amsa maganin miyagun ƙwayoyi ba, amma tare da ƙananan zaɓuɓɓuka don magani, zolpidem na iya kasancewa zaɓi mai kyau ga iyalan da suke da matsanancin matsayi na kowane zarafi don kyautatawa.
Kalma Daga
Kodayake wadannan shari'o'i da ƙananan gwaje-gwaje na iya zama masu ƙarfafawa, yana da kyau ga iyalan da abokai na waɗanda ke da matukar damuwa don magance wadannan sakamakon tare da ƙaddamarwa mai girma. Yana da mahimmanci cewa zolpidem ba zai taimaki yawancin marasa lafiya wadanda ke fama da wannan cuta ba. Duk da haka, akwai yiwuwar bege: ƙarin bincike yana da garanti.
Ba a fahimci yadda zolpidem zai iya inganta waɗannan yanayi ba. Zai iya rinjayar daidaitattun sakonni da haɗi tsakanin bangarori daban-daban na kwakwalwa. A cikin misali, idan kwakwalwa ta makale a cikin rashin jin dadi saboda rashin daidaituwa da dakarun da ke adawa, zai iya taimaka wajen magance gwagwarmayar a cikin kyakkyawar jagora. Wajibi ne a fahimci wadannan sassan. Ƙididdigar binciken gwaji mafi girma zai iya taimaka mana mu fahimci wanda ke fama da mummunar cututtuka na jiki zai amfana daga yin amfani da zalpidem-kuma me ya sa.
> Sources:
> Bomalaski, MN et al . "Zolpidem for Treatment of Neurologic Disorders: A Review System." JAMA Neurol . Aka buga a ranar Jumma'a 26, 2017. Dalilan: 10.1001 / jamaneurol.2017.1133.
> Kilduff, TS da Mendelson, WB. "Magungunan maganin ƙwaƙwalwa: Ma'anar Ayyuka da Ƙwararren Magunguna," a cikin ka'idoji da ka'idojin magani na barci . Edited by Kryger MH, Roth T, Dement WC. St. Louis, Missouri, Elsevier Saunders, 2017, p. 429.
> Miyazaki, Y et al. "Ƙarfafawa na zolpidem don dystonia: nazari a tsakanin daban-daban subtypes." Front Neurol . 2012 Apr 17; 3: 58.
> Sateia, MJ et al . " Dokokin Gudanar da Harkokin Gudanar da Harkokin Gudanar da Harkokin Kiwon Lafiyar Kwayoyi na Kwayoyin Kwayoyin Kwayoyin Kwafi a cikin Adult: Cibiyar Nazarin Harkokin Kasuwancin Cibiyar Nazarin Harkokin Kasuwancin {asar Amirka ." Jaridar Clinical Sleeping Medicine . 2017; 13 (2) 307-349.
> Sutton, JA da Clauss, RP. "Binciken shaidu na zolpidem yana da tasiri a cikin rashin lafiyar jiki ba bayan lalacewar kwakwalwa saboda cutar shan kashi, ciwon daji da kuma hypoxia: A Amincewa da ƙarin gwaji." Brain Inj . 2017; 31 (8): 1019-1027.