Za a iya ciwo cutar ta HPV don bunkasa cututtukan ciwon huhu?
A cikin binciken 2008 game da 53 binciken da aka wallafa a cikin mujallar Lung Cancer , marubuta sun bayyana cewa HPV na iya zama babban abu na biyu na cutar kanjamau bayan shan taba cigaba, kuma ana bukatar ƙarin bincike game da wannan batu. Mene ne muka koya tun lokacin? Shin akwai haɗin hanyar wasu nau'i tsakanin HPV da ciwon huhu na huhu?
Menene HPV (Human Papillomavirus)?
HPV (ɗan adam papillomavirus) shine tarin kwayoyi fiye da 200 wanda zai iya cutar da mutane.
Daga cikin wadannan, kimanin 30 suna iya haifar da ciwon daji, tare da yawancin ciwon "ciwon daji" da ke HPV 16 da HPV 18.
Kusan sau da yawa HPV ta yada ta hanyar fata-to-skin, akai-akai a jima'i. Yawancin cututtuka tare da HPV sun bayyana a cikin shekaru biyu ba tare da haifar da wani matsalolin ba, amma wasu suna ci gaba. Cutar da ciwon "ciwon daji" na HPV baya nufin mutum zai ci gaba da ciwon daji. A gaskiya, yawancin cututtuka da HPV ba su ci gaba da ciwon ciwon daji ba.
Ana san HPV ne don kamuwa da kwayoyin halittar jiki kuma yana aiki don katse al'amuran salula wanda ke kula da ci gaban kwayar halitta. Ko da lokacin da wannan ya faru, yawancin wadannan kwayoyin halitta zasu iya ganowa kuma an cire su ta hanyar tsarin rigakafi.
HPV da Ciwon daji
An riga an kafa HPV a matsayin mai taka rawa a cikin mafi yawan lokuta na ciwon daji na mahaifa, da kuma wasu lokuta na ciwon daji, cututtuka na penile , kimanin kashi 95 na maganin cututtuka, da kuma kashi 70 na magungunan maganin, musamman ma wadanda ke faruwa a matasa, ba -mafin mata.
HPV 18 da kuma HPV 16 suna da dalilin kusan kashi 70 cikin dari na cututtuka na mahaifa na HPV, kuma HPV 16 yana da alhakin fiye da rabi na HPV da ke haifar da ciwon maganganu.
Saboda haka, mun sani cewa cututtuka na HPV zai iya haifar da ciwon daji da kuma cewa yana sa wasu ciwon daji kusa da yankin huhu. Har ila yau, mun san cewa cututtuka na cututtuka na iya taimakawa wajen bunkasa ciwon huhu na huhu, alal misali, wadanda ke dauke da kwayar cutar HIV suna iya haifar da ciwon huhu na huhu fiye da wadanda basu da cutar HIV, amma zai iya haifar da ciwon huhu na huhu?
Ciwon daji na huhu da ke haifar da ƙwayoyin cuta
Yin kallon abubuwan da ke haifar da ciwon huhu na huhu shine muhimmiyar mahimmanci. Abin takaici, damuwa cewa cutar kanjamau ita ce cutar shan taba a wasu hanyoyi da raunin ci gaba a cikin kimantawa da sauran abubuwan da zai yiwu. Amma ciwon huhu ya faru a cikin wadanda ba masu shan taba ba. A Amurka, kashi 20 cikin 100 na matan da ke ciwon ciwon huhu ba su taɓa taba taba taba ba, kuma wannan adadin ya kai kashi 50 cikin dari na matan da ke fama da ciwon huhu a cikin dukan duniya wanda ba a taba shan taba ba. A gaskiya ma, ciwon daji a cikin wadanda basu taba shan taba ba shine asali na shida da ke haifar da mutuwar cutar kanjamau a Amurka.
Mun kuma san cewa ba duk wanda ke shan taba yana tasowa ba, kuma shan taba yana iya aiki tare da wasu abubuwan haɗari don haifar da ciwon daji. Shin HPV ɗaya ne daga waɗannan abubuwan?
Tarihi da Tarihi na HPV da Ciwon Cutar Lung
Da yiwuwar cewa HPV na iya taka muhimmiyar rawa wajen bunkasa ciwon huhu a cikin 1979. Da yawa daga karatun tun daga lokacin sun sami shaida na DNV DNA a cikin ciwon huhu, amma wannan ya bambanta sosai dangane da ilimin geography . A Amurka, ana samun HPA na DNV a kimanin kashi 15 cikin dari na ciwon huhu na huhu, dangane da binciken, tare da HPV 16 da kuma HPV 18 mafi yawanci-abubuwan da suka fi rikitarwa a ciwon sankarar mahaifa.
A Turai, gabanin HPA na DNV a cikin kututtukan huhu yana da kashi 17 cikin dari, amma wannan adadin ya kai kashi 69 cikin 100 a Girka da Taiwan da 79 bisa dari a Japan. Mun san cewa ciwon huhu a cikin masu shan taba ba shi da yawa a cikin Asiya. Har ila yau, mun san cewa cutar ta HPV ta zama mafi yawanci a cikin kwayar cututtuka na huhu na mata da wadanda ba masu shan taba ba fiye da maza da mutanen da suke shan taba.
Ɗauki biyu na 2016 sun nuna waɗannan bambancin yanki har ma da kara. A cikin binciken daya, an gano cewa matan Taiwan suna da matukar muhimmanci wajen haifar da ciwon huhu na huhu ba idan an bayyana su a HPV ba. Sabanin haka, bincike na kasar Sin bai sami wata dangantaka tsakanin kwayoyin cutar ta HPV ba (alamar nunawa) da kuma ci gaba da cutar kanjamau.
Shin cutar ta HPV tana haifar da ciwon huhu?
Ko da yake an gano HPV a cikin kwayoyin cutar kanjamau, musamman ma a cikin kwayar cutar kwayar cutar kwayar cutar ta jiki , da mahimmancin ganowar HPV a cikin kwayar cutar ciwon huhu a yanzu ba a san ko fahimta ba. Bari mu dubi wasu dalilai cewa wannan tambaya bata sauƙin amsawa ba.
Cutar vs. Correlation
Ko bayyanuwar HPV a cikin ciwon daji na huhu yana nuna lalacewa (cewa HPV tana sa ciwon huhu) shi ne wata tambaya. Kawai saboda akwai daidaituwa tsakanin abubuwa 2-a cikin wannan yanayin kasancewar HPV da ci gaba da ciwon huhu na huhu - ba shi da kome game da lalacewa. Hanyar mafi sauki ta bayyana wannan ita ce ta amfani da misali. Akwai dangantaka mai karfi a tsakanin cin ice cream da nutsar amma wannan ba yana nufin cewa cin ice cream sa haddasawa zasu faru. A wannan yanayin, akwai dangantaka tsakanin abubuwa biyu waɗanda ba a haɗa su ba.
Bugu da ƙari, maimakon lalacewa ko haɗa kai ba tare da alaƙa ba, kasancewar HPV da ciwon huhu na huhu zai iya zama tambayar "kaza da kwai". Wanne ya zo da farko? Zai yiwu yadun nama wanda ya lalace ta wurin ciwon daji shine mafi sauƙin kamuwa da cutar HIVV. Idan wannan shine lamarin, ana dauke da HPV a matsayin "kamuwa da ladabi" kamar kamuwa da cututtukan da ke fama da kwayar cutar HIV. Tare da AIDs, shi ne lalacewa da cutar ta HIV ta haifar da jiki mai saukin kamuwa da cututtuka irin su pneumocystis pneumonia, ba sauran cututtuka da ke haifar da cutar HIV ba.
Ciwon ƙwayar cutar kututtukan tumatir vs. Metastases
A wasu nazarin, ciwon huhu na huhu ya zama yafi kowa a cikin wadanda suka kamu da ciwon sankarar mahaifa. A cikin wani binciken mai zurfi (wanda ya tabbatar da cewa HPV yana da wuya idan ya kasance da dangantaka da tarin ciwon huhu na huhu a Kanada da Arewacin Amirka), an gano cewa kamuwa da cutar HPV ne kawai a kashi 1.5 cikin dari na marasa lafiya, kuma duk waɗannan marasa lafiya sun riga sun sha wahala. Magungunan ciwon sikila (irin su cervical ko maganin ciwon daji) alaka da HPV. Kodayake wadannan cututtuka na huhu sun zama kamuwa da cutar kututtukan jini, tambayar da aka dauka shi ne cewa a maimakon haka, waɗannan cututtuka na iya wakiltar ciwon daji na metastatic zuwa ga huhu daga tsohuwar cututtuka da maganin ciwon daji.
HPV a matsayin Carcinogen
Muna da tabbacin cewa HPV tana aiki ne kamar kwayar cutar shan- jiji -abin da ke haifar da ciwon daji-yana iya zuwa ga mahaifa, penile, na daji, da kuma maganin cututtuka, amma menene cutar ciwon huhu? Idan HPV yana da kwayar cutar ciwon huhu, tunanin yanzu yana da cewa HPV na iya kasancewa mai haɗin gwiwa don bunkasa ciwon huhu na huhu. A wasu kalmomi, cutar zata iya aiki tare da wasu abubuwan haɗari irin su radon ko cigaba na taba don samar da ciwon daji. Har ila yau an yi tunanin cewa, ba kamar cutar ciwon jiji ba, idan HPV ta kasance mawuyacin hali ne ko mahaukaci a cikin ciwon huhu na huhu, mai yiwuwa wannan yana iyakance ne kawai ga ƙwayar ciwon huhu.
HPV da Ciwon Cutar Cancer Masifa
Abin sha'awa, mutanen da suke da shaidar HPV a cikin kwayoyin cutar kanjamau na ƙwayar cuta suna da alamun da suka fi dacewa da wadanda ba su da shaidar HPV a cikin kwayoyin cutar kanjamau. Wannan binciken ya ba da tabbacin matsayin yiwuwar HPV a cikin ciwon huhu na huhu yayin da aka kwatanta da cutar ta hanyar maganin. Magungunan maganganun da ke da cutar ta HPV suna da kyakkyawar ganewa fiye da wadanda suke da alaka da amfani da taba.
Layin Ƙasa
Zai yiwu wani lokaci kafin mu san abin da, idan akwai wani, dangantaka ta gaskiya tsakanin HPV da ciwon huhu ta ainihin ita ce. Kamar yadda muka gani, akwai wasu canje-canje da ba mu fahimta ba. Za'a buƙaci ƙarin bincike don kimanta kasancewar HPV a cikin kwayoyin cutar kanjamau, da kuma bayyana manyan bambance-bambancen gefen da suke neman zama. Kamar yadda muka gani a sama, har ma ma'anar daidaito tsakanin HPV da ciwon huhu na huhu ba ya nuna lalacewa. Zai iya kasancewa ba tare da alaƙa ba, ko kuma cewa cutar kanjamau ta zama mai saukin kamuwa da kamuwa da cuta tare da HPV kuma cutar kuturta ta zama "dalilin" na kamuwa da cutar ta HPV maimakon ta hanyar da ke ciki.
HPV Rigakafin
To, menene hakan yake nufi don rigakafi? Hanyar yin amfani da hotuna ga HPV ta hanyar jima'i mai jituwa shine farawa mai kyau. Ga wadanda suke a kan shinge game da maganin rigakafin HPV , wannan zai iya samar da ƙaramin goyon baya.
Rage ƙwayar cutar Ciwon daji
Abin godiya mun san abubuwa da yawa na cutar ciwon huhu a kan abin da muke da iko. Bincika waɗannan matakai 10 don hana ciwon daji . Tabbatar cewa kun duba gidanku don radon - babbar hanyar cutar ciwon huhu a cikin masu shan taba bane kuma kuyi la'akari da kara wasu daga cikin wadannan abinci da za su iya rage ƙwayar cutar ciwon huhu a cikin abincin ku. Kuma kar ka manta: duk wanda ke da huhu zai iya samun ciwon huhu na huhu.
Sources:
Chang, Y., Keeney, M., Law, M. et al. Binciken ɗan adam na papillomavirus a cikin ƙananan ƙwayoyin cellcin ciwon huhu. Harkokin Halittar Mutum . 2015. 46 (11): 1592-7.
Fan, X., Yu, K., Wu, J. et al. Daidaita tsakanin kwayar cutar kwayar fata da kwayar cutar mutum da kamuwa da cutar papillomavirus da dangantaka da bayyana p53 da p16. Tumo Biology . 2015. 36 (4): 3043-9.
Lin, F., Huang, J., Tsai, S. et al. Ƙungiyar dake tsakanin kamuwa da cutar kanjitalomavirus da cutar kanjamau na mata: Wani bincike kan ƙungiyar jama'a. Medicine (Baltimore) . 2016 95 (23): e3856.
Cibiyar Cancer ta Kasa. Masana'antu da Ciwon Kwayoyin Mutane: Tambayoyi da Amsoshin. 02/19/15. https://www.cancer.gov/about-cancer/causes-prevention/risk/infectious-agents/hpv-fact-sheet.
Prabhu, P., Jayalekshmi, D., da M. Pillai. Ciwon kwari da ƙwayar cutar ta mutum (HPVs): Yin nazarin Shaidun Mujallar. Journal of Oncology . 2012. ID 750270.
van Boerdonk, R., Daniels, J., Bloemena, E. et al. Magungunan ciwon huhu na papillomavirus mai tsanani-kwayar cutar kwayoyin shaida: shaidar kwayoyin hujjoji ga tsarin ƙwayar cuta. Jaridar Thoracic Oncology . 2013. 8 (6): 711-8.
Zhai, K., Ding, J., da H. Shi. Kwayar cutar ta HPV da ciwon huhu a cikin mahaifa: wani zane-zane. Jaridar Clinical Virology . 2015. 63: 84-90.