Binciken Ironloadload Daga Magunguna Masu Sauƙi
Matsakaicin ƙarfe shine yanayin inda akwai ƙarfe cikin jiki fiye da jiki zai iya cirewa. Lokacin fasaha don ƙarfe kan bugun jini shine hemochromatosis. Akwai dalilai guda biyu na ƙarfe na baƙin ƙarfe: 1) haɓakar haɓakar haɓurwa ko 2) haɓakar hemochromatosis transfusional. Abubuwan da ke cikin halayyar halayen jini shine yanayin da aka raba a cikin iyalai. Ruwan hemochromatosis na jini yana faruwa ne lokacin da mutum yana buƙatar ƙwayar jinin jini (RBC).
An sami ƙarfin a ciki cikin haemoglobin , mai gina jiki a cikin RBC. Ayyukan baƙin ƙarfe don taimakawa wajen kawo isasshen oxygen zuwa dukan kyallen. Kullum al'ada yana karɓar nauyin baƙin ƙarfe daga abincinku don ci gaba da aikin RBC. Idan ba ku ci abinci mai yawa ba tare da ƙarfe, matakan ƙarfinku sun zama ƙananan sakamakon sakamakon anemia na baƙin ƙarfe . Lokacin da RBC sun kai ga ƙarshen rayuwarsu, an yi amfani da ƙarfe cikin su don amfani da sabon RBCs.
Me yasa Sakamakon RBC da yawa ke haifar dashi?
An sami ƙarfin a cikin dukkan RBC a cikin sashin jini. Sabili da haka duk wani karfin da RBC ya karɓa shi ne ainihin jigilar baƙin ƙarfe (IV). Matsalar ita ce jiki yana da iyakancewa akan ikonsa don kawar da wannan ƙarfe mai yawa. Bugu da ƙari, mutanen da ke dauke da maganin ƙwayar cutar sun karu da baƙin ƙarfe fiye da yadda suke bukata daga cin abincin su.
Wane ne ke da hatsari don sauyawar ƙarfe mai sauƙi?
Duk wanda ya karbi raunin jini na RBC yana da haɗari, amma mutanen da suke dogara da ƙwayar cutar suna cikin haɗari.
Wannan zai hada da mutanen da ke fama da ciwon sikila wadanda suka sami ciwon bugun jini (ko kuma suna cikin haɗari mai tsanani don bugun jini ), beta thalassemia manyan , Diamond Blackfan Anemia , apilia anemia , da kuma myelodysplastic ciwo a tsakanin wasu. Mutanen da ke fama da ciwon daji wanda ke buƙatar fassarar jini a yayin jiyya da chemotherapy ko ƙwayar launuka na kasusuwan kuma suna fuskantar hadarin ƙwaƙwalwar baƙin ƙarfe na transfusional.
Ta Yaya Likita na Likita Kula da Kyautin Abincin?
Mutanen da za su buƙaci karuwa a duk tsawon lokaci suna kulawa da hankali don ƙarfin baƙin ƙarfe. A cikin wadannan marasa lafiya, ana iya ganin rikitaccen ƙarfe bayan 12 zuwa 15 RF transfusions. An yi la'akari da yawan karfin ƙarfe a cikin gwajin jini wanda ake kira ferritin da farko. Ferritin yana wakiltar adadin ƙarfe da aka ajiye a jikinka. Ferritin yana da yawa a cikin jadawali, kowannensu zuwa wata uku, don likitanku zai iya ganin yadda yake tasowa (wato, darajar ta karu?). Chelation, kalmar magunguna da ake amfani da su don cire baƙin ƙarfe, an fara farawa ne bayan da ferritin ya fi 1000 ng / ml. Abin baƙin ciki, matakan ferritin suna shafar abubuwa da yawa fiye da ƙarfin baƙin ƙarfe. Za a iya ganin matakan tsararru mai zurfi a lokacin rashin lafiya da kumburi.
Saboda ƙuntatawa tare da ferritin, wasu hanyoyin da za a iya gwada ƙarfin baƙi sun ci gaba. A baya can, an yi amfani da sauke nauyin baƙin ƙarfe tare da hanta biopsies inda aka cire kananan hanta kuma an auna shi don baƙin ƙarfe. A halin yanzu, ana iya kula da mafi yawan mutane tare da hotunan haɓaka mai kwakwalwa (MRI) na hanta da / ko zuciya. MRI na iya ƙididdige ƙwayar ƙarfin baƙin ƙarfe (LIC) kama da sakamakon hawan kwayar hanta.
An fara tayar da launi lokacin da LIC ya fi 3 MG ta kowace hanta. Hakazalika, MRI na zuciya zai iya auna nauyin baƙin ƙarfe wanda yake cikin ƙwayar zuciya.
Waɗanne Dama zasu iya faruwa tare da Iron Overload?
Da zarar duk wurare na wurare don adana baƙin ƙarfe ba su da samuwa, za'a iya adana ƙarfe a cikin hanta, zuciya, pancreas, da kuma gabobin endocrin (wanda ake kira gland). Lokacin da aka ajiye baƙin ƙarfe a cikin waɗannan wurare, yana lalata kwayar. Wannan na iya haifar da fibrosis ko maganin hanta, cardiomyopathy (cututtukan zuciya), ciwon sukari (saboda baƙin ƙarfe a cikin pancreas), hypothyroidism (ƙananan matakan hormone thyroid) da hypogonadism (haifar da rage libido da rashin ƙarfi a cikin maza da rashin na hawan hanzari cikin mata).
Don hana wannan rikicewar rikice-rikice mai haɗari, mai rikitarwa na rayuwa, ana daukar nauyin karfin baƙin ƙarfe.
Ta Yaya Aka Yi Maimaita Abincin Musayar Juyin Halitta?
An yi amfani da ƙarfe mai sauƙin karfin jini daga maganin ƙwayar cutar, tare da maganin da aka ba da shi don cire baƙin ƙarfe daga jiki. Akwai maganin likita uku.
- Deferoxamine (Ƙasar)
- Deferasirox (Jadenu ko Exjade)
- Deferiprone (Ferriprox)
Harkokin ilimin lissafi : Idan a wasu wurare za ku iya dakatar da fassarar jini, za a iya magance nauyin ƙarfe da serial phlebotomy. Hannun kamala yana da kama da kyautar jini inda aka cire jini mai yawa daga jiki. A cikin RBCs an cire shi ne baƙin ƙarfe kuma a lokacin da waɗannan sun maye gurbinsu da kasusuwan kasusuwan zai yi amfani da ƙananan ƙarfe da aka adana cikin jikinka.
> Sources:
> Schrier SL da Bacon BR. Kayan Farfadowa na Thalassemia da Sauran Jirgin Kasuwanci da Ƙananan Jirgin Ƙasa da Ƙananan Abinci Sauran Bayan Sauran Halittar Hemochromatosis. A: UpToDate, Post TW (Ed), UpToDate, Waltham, MA.