Waɗanne hanyoyi ne na iya hana cutar ta mace tare da ciwo na Lynch
Mene ne zaka iya yi don hana ciwon daji a cikin gabobin mata (cutar gynecologic) idan kana da ciwon Lynch?
Duk da yake rashin alheri ba mu da hanyoyin da za mu iya hana ciwon daji ga mutanen da ke fama da ciwon Lynch Syndrome-ko kuma ba tare da ciwon Lynch ba game da wannan al'amari - mun san wasu abubuwa da za ku iya yi wanda zai iya rage yawan hadarin ciwon cancers na ovaries ko mahaifa .
Har ila yau, mun san hanyoyin da za a jarraba ga ciwon mata, kuma ta hanyar yin hakan, muna fatan samun wadannan ciwon daji a cikin ɓangarorin da suka wuce.
Bayani
Lynch ciwo kuma an san shi a matsayin wanda ba shi da kariya ba tare da maganin cutar ciwon daji ba (HNPCC) . Wannan yanayin ne wanda aka haifa wanda za'a iya haifar da mahaukaci a cikin kwayoyin daga tsara zuwa tsara.
Ciwon ciwo yana da dangantaka da canje-canje a cikin jinsin hudu: MLH1, MSH2, MSH6, da PMS2. Wadannan canje-canjen sun zama gadon sarauta a cikin tsari mafi girma, ma'ana cewa kawai ne kawai ka buƙaci ka gaji wani mummunar mahaifa daga daya daga iyayenka don ka fuskanci hadarin ciwo. Lynch ciwo yana da alhakin kashi biyu zuwa kashi bakwai na ciwon daji na maza, kuma yawancin shekarun tarin ciwon ciwon daji yana da 45 a wani tare da Lynch syndrome.
Rikicin Cancer
Ciwon daji na yau da kullum ga mutanen da ke fama da ciwon Lynch sun hada da:
- Ciwon daji na Colon - 80 bisa dari
- Cutar ciwo - 11- 18 bisa dari
- Hanyar daji da kuma bile cancer - 2 zuwa 7 bisa dari
- Bladder da ciwon koda - 4.5 zuwa 5 bisa dari
- Ciwon daji na intestinal - 1 zuwa 4 bisa dari
- Ciwon daji na Brain - 1 - 3 bisa dari
Rashin lafiyar kwayoyin cutar kwayar cutar mace sun hada da:
- Ciwon mahaifa - kashi 20 zuwa 60 na mata
- Oganian ciwon daji - kashi 9 zuwa 12 cikin mata
Wannan yanayin yana nufin mutane zuwa wasu magunguna, kamar su ciwon nono .
Rage Rashin Ciwon Canji
Lokacin da yake magana game da rage haɗari, yana da muhimmanci a fara yin bambanci. Yawancin gwaje-gwajen gwaje-gwaje za ku ji game da su ne nau'i na ganowar farko. Wadannan gwaje-gwajen ba su hana ciwon daji, ko ma ƙananan haɗarin cewa za ku ci gaba da ciwon daji. Maimakon haka, suna ƙara samun damar cewa za'a iya gano ciwon daji yayin da ya karami. Kuma mafi yawan cututtuka sun fi karfin hali, kuma watakila ma da magani, lokacin da suke ƙananan.
Ya bambanta, akwai abubuwa da mutane zasu iya yi don rage haɗarin ciwon daji na ci gaba da ciwon daji a farkon wuri. Cin abinci mai kyau da kuma yin fashewa a cikin wannan rukuni. Labaran ciwon kankara , duk da haka, yana da mahimmanci a cikin gwajin gwaje-gwaje. Yana bayar da damar gano ciwon daji a farkon lokacin-amma yana iya taimakawa wajen rigakafi, lokacin da aka gano magungunan ƙwayar cuta , sannan a cire su, kafin su koma cikin ciwon daji.
Janar Tsarin Rigakafin Cancer
Yana da muhimmanci a lura da cewa mata da Lynch ciwo, baya ga sauran matakan da za a tattauna, ya kamata a shawo kan gwajin daji wanda mata ba tare da ciwon Lynch ba. A gaskiya ma, wannan yana da mahimmanci a tuna, saboda yana da muhimmanci a kula da al'amurran kiwon lafiya wanda zai iya faruwa idan ba ku da Lynch ciwo.
Alal misali, matan da ke da ciwon nono a wasu lokuta sukan zama mai da hankali a kan rigakafi na nono don kada su manta da bin bin yaduwar cutar don ciwon ciwon daji kamar yadda yake "karami."
Tsayawa wannan a tuna yana da muhimmanci ga mata da Lynch ciwo don yin magana da likita game da abubuwan da suka shafi kiwon lafiya ba tare da alaka da Lynch ciwo ba. Alal misali, yana da mahimmanci akan magana game da rigakafin cututtukan zuciya ko da yake wannan ciwo ba zai haifar da hadarin cututtukan zuciya ba, saboda kowa yana cikin hadari.
Ƙarin Ƙarƙwarar Ƙarƙashin Ƙarƙashin Ƙarƙwarar Ƙwararrun Mata na Lynch Syndrome
Don ganin abin da za a iya dauka don rage yiwuwar samun ciwo ta ƙara yawan kwayar cutar Lynch, masu bincike sun dubi yiwuwar samun gwaje-gwaje da yawa.
Ragewar Ovarian da Ciwon Ƙwayar Ciwon daji
Akwai hanyoyi daban-daban don rage haɗarin mutuwa daga ovarian ko ciwon mahaifa ga mata masu fama da Lynch.
A cikin nazarin 2006 da aka buga a New England Journal of Medicine , masu bincike sun kammala aikin maganin rigakafi tare da shinge-oophorectomy na biyu - wata hanya ce mai mahimmanci don hana endometrial (uterine) da ciwon daji na ovarian a cikin mata da Lynch syndrome. Binciken binciken da aka yi a shekara ta 2011 game da bincike kan farashin hanyoyin da aka samu, haɗarin haɗari na haɗari ya zama mafi dacewa.
Tunda kasancewa mai bada shawara naka yana da mahimmancin samun kyakkyawan magani zai yiwu, yana iya taimakawa wajen san inda wasu daga cikin waɗannan shawarwari suka fito. Bayan haka, da kuma bayan gwada zabi daban-daban tare da sha'awar kanka, za ka iya yin shawarar da yafi dacewa a kanka.
Masu bincike sun dubi wasu hanyoyi don rage hadarin mutuwa daga wadannan cututtuka. Wasu abubuwa da aka gwada sun hada da:
- Nazarin gynecologic shekara
- Zanewa ta shekara ta amfani da biopsy endometrial , ultrasonography transvaginal, da magani C 125
- M cirewa daga cikin mahaifa, ovaries, da tubes na fallopian a shekaru 30 (ko akalla kafin shekaru 35)
Masu binciken sun yanke shawara cewa mafi kyawun zabin (tiyata) ya haifar da mummunar hadarin ciwon daji da kuma rashin rinjaye (gwaje-gwajen shekara-shekara) ya haifar da mummunar haɗarin ciwon daji. Wannan ya kasance tabbatacciyar ganyayyaki da ciwon daji na uterine. Amma, overall rayuwa ba ta canja yawa. A matsakaici, matan da suke da mahaifa, ovaries, da tubes da aka cire a cikin shekaru 30 sun rayu shekaru uku fiye da wadanda ke da jarrabawar gynecologic shekara.
Musamman, ciwon daji na ovarian ya faru a cikin kashi takwas cikin dari na matan da suke shawo kan gwaje-gwaje shekara-shekara, kashi hudu cikin dari waɗanda suke da nazarin shekara-shekara, kuma kasa da 1/10 na kashi bisa dari na mata waɗanda ke da tiyata. Ciwon daji na mahaifa ya faru a cikin kashi 49 cikin dari na matan da ke shawo kan gwaje-gwajen shekara-shekara, kashi 18 cikin 100 wanda ke da alkaluman shekara-shekara, kuma kasa da 1/10 na kashi bisa dari na matan da ke da tiyata. Kodayake yana da mahimmanci, har yanzu yana yiwuwa ga mata su sami ganyayyaki ko ciwon mahaifa a yayin da aka cire waɗannan sassan. Misali shi ne peritoneal carcinoma.
Mata masu yin nazarin shekara-shekara sun kasance kimanin 77, wadanda suka yi nazarin shekara-shekara sun kasance kimanin 79, kuma waɗanda suka yi aikin tiyata sun kasance kimanin 80.
Rage Rashin ƙwayar wasu Magunguna
Akwai sharuɗɗa masu yawa don nunawa ga mutanen da ke fama da ciwon Lynch don ganowa na farko da wasu cututtuka. Alal misali, a kowace shekara ko biyanin colonoscopies an bada shawarar farawa daga shekaru 20 zuwa 25 ko biyar na kasa da shekaru wanda dangi ya ci gaba da cutar. Yi magana da likitanku game da waɗannan gwaje-gwajen gwaje-gwajen don sanin abin da ke daidai a gare ku.
Sources:
Ƙasar Amirka ta Cibiyar Nazarin Harkokin Kwayoyi. Cancer.Net Lynch Syndrome. 12/2004. http://www.cancer.net/cancer-types/lynch-syndrome
Bonis, P., Ahnen, D., da L. Axell. Lynch ciwo (wanda aka halatta wanda ba shi da nasaba da ciwon daji) ba tare da ɓarna ba. UpToDate . Updated 05/12/16.
Chen, L., Yang, K., Little, S., Cheung, M., da kuma A. Caughey. Gynecologic Cancer Prevention in Lynch Syndrome / Hereditary Nonpolyposis Ƙananan Ciwon daji Families. Obstetrics da Gynecology . 2007. 110 (1): 18-25.
Schmeier, K., Lynch, J., Chen, L. et al. Magunguna na Ciwon Gida don Rage Rashin Ciwon Magunguna na Gynecologic a cikin Cutar Lynch. New England Journal of Medicine . 2006. 354 (3): 261-9.
Vasen, H., Ignacio, B., Aktan-Collan, K. et al. Dokokin da aka sabunta don magance ciwon Lynch (HNPCC): shawarwari daga kungiyoyin masana Turai. Gut . 2013. 62 (6): 812-23.
Yang, K., Caughey, A., Little, S., Cheung, M., da L. Chen. Yaduwar Kwarewa ta Cikin Gida na Harkokin Ciwon Halitta A Cikin Gida Game da Gynecologic Surveillance ga Mata daga Gidajen Harkokin Cutar Abun Harkar Kwayoyin Bauta (HNPCC). Ciwon iyalan iyali . 2011. 10 (3): 535-43.