SSRI / SNRI Antidepressants na Fibromyalgia, Ciwo na Rashin Gwaji

by Adrienne Dellwo; Binciken by Grant Hughes, MD

Sun yi ba kawai don takaici ba

Daga duk maganin jibromyalgia (FMS) da ciwo na gajiya ( ME / CFS ), magungunan antidepressants na iya zama mafi wuya ga mutane su fahimta. Yana da kyau don mutane su damu game da dalilin da ya sa aka tsara waɗannan magunguna don yanayin da ba ciki ba.

Duk da haka, shaidun shaida masu girma sun nuna cewa maganin antidepressants na da tasiri sosai ga FMS, kuma zuwa karami, ME / CFS.

Magungunan rigakafi sun canza hanyar wasu masu amfani da kwakwalwa suna aiki a kwakwalwarka, kuma irin wannan neurotransmitters suna cikin FMS, ME / CFS, da kuma mummunar cuta mai tsanani.

Wadannan nau'o'in maganin antidepressants guda biyu wadanda aka nuna zasu zama mafi tasiri akan alamun FMS shine:

Ma'aikata Masu Saukewa na Serotonin Reuptake (SSRIs)
Serotonin Norepinephrine Reuptake Inhibitors (SNRIs)

Menene SSRIs & SNRIs

Serotonin da norepinephrine sune neurotransmitters-chemicals a cikin kwakwalwa da ke aika saƙonni daga wani neuron (ƙwaƙwalwar ajiyar) zuwa wani. Kowane kulla da ayyuka masu yawa.

Ayyuka na Serotonin sun hada da ciwo mai zafi da kuma ɓangaren ɓangaren barci. Kwajinka yana amfani da serotonin don ƙirƙirar melatonin, wanda zai taimaka maka ka barci.

Norephinephrin yana da nasaba da ƙarfin jiki, amsawa, da ƙwaƙwalwa. Kwaƙwalwarka yana amfani da norepinephrine don ƙirƙirar dopin neurotransmitter dopamine wanda ke hulɗa da mayar da hankali ga tunani, motsa jiki, da kuma daidaitawa.

Abubuwa da yawa a cikin serotonin da norepinephrine suna da alaka da wasu lokuta na FMS da ME / CFS. SSRIs / SNRIs suna samar da mafi yawa daga cikinsu ta hanyar rage jinkirin reuptake, wanda shine lokacin da suke tunawa bayan amfani don haka za'a iya sake sake su. (Ƙarin bayani: Fahimtar Reuptake .)

Daga cikin kwayoyin FDA waɗanda aka yarda da su don FMS, biyu daga cikin uku sune SNRIs.

(Babu kwayoyi masu FDA-sun yarda da ME / CFS.) Su ne:

Sauran SNRIs suna kan kasuwa kuma ana iya sanya musu takaddama akan wadannan cututtuka. Sun hada da:

Mafarki (venlafaxine)
Pristiq (desvenlafaxine)

SSRIs, wanda wasu lokuta ana sanya su-lakabi, sun haɗa da:

Hanyar (Citalopram)
Lexapro (escitalopram)
Luvox (fluvoxamine)
Paxil / Pexeva (paroxetine)
Prozac / Sarafem / Selfemra / Rapiflux (fluoxetine)
Zoloft (sertraline)

Risks: Raunin maganin Serotonin

SSRIs, SNRIs, da sauran magunguna wadanda ke ƙara serotonin zasu iya haifar da yanayin da ake ciki da ake kira cututtukan serotonin. Rashin haɗari yana ƙarawa lokacin da kake ɗauka fiye da guda daya mai sauƙi mai sauƙi, wanda zai iya haɗawa da magungunan maganin likitanci, kayan wasan motsa jiki da ma wasu kari.

Don rage haɗarin ciwon serotonin, yana da mahimmanci a gare ka ka gaya wa likitanka da likitan komai game da duk abin da kake ɗauka.

Kuna iya samun ƙarin bayani game da ciwo na serotonin, ciki har da abin da kwayoyi da kariya ke shafar ciwon sukari da kuma abin da ke nunawa a nan: Serotonin Syndrome

Risks: Kashe kansa

SSRIs, SNRIs, da sauran masu maganin antidepressants sun bukaci FDA su dauki gargadi na bango-mafi yawan firgita - game da kara yawan hadarin kashe kansa ko tunani da kuma halaye.

Yana da mahimmanci ga duk wanda ke shan wadannan kwayoyi ya san abin da ya faru, kuma yana da mahimmanci ga abokai da iyalansu su san game da shi. Wadannan su ne waɗanda ke nuna alamun gargadi.

Idan ka ga kanka yana da tunanin tunanin saiti, samun taimako nan da nan. Daga ko'ina a Amurka, zaka iya kira 1-800-273-8255.

Wannan lamari ne na VA, amma kowa ya maraba don kira. Ya kamata ku yi magana da likitanku game da waɗannan tunani kuma ya kamata ku daina shan magani.

A nan akwai ƙarin kayan aikin rigakafin kashe kansa:

Bayanin FDA na Ma'aikatan Lafiya
Ƙungiyoyin Crisis na Kungiyar Kaifi (US): 1-800-784-2433 ko 1-800-273-8255

Alamun gargadi na kashe kansa
Yadda za a taimaki Mutumin da yake Cutar

Risks: Ƙasashewa

Kashe SSRIs / SNRIs yana dauke da nasa hadarin. Tsayawa da sauri zai iya haifar da abin da ake kira nakasar ciwo, don haka ya kamata ka yi magana da likitanka game da hanyar da ta dace don cire kanka daga cikin miyagun ƙwayoyi.

Hanyoyin cututtuka na ciwon ƙetare sun haɗa da:

Wulo
Abin ciwo
Jiɗa
Abin ciwo
Insomnia
Raguwa da damuwa
Dizziness
Majalisa
Binciken tsoro
Madaba
Tantling sensations
Mahimman mafarkai
Sugar wucewa
Hanyoyin firgita na wutar lantarki

Rashin bayyanar cututtuka na iya zamawa daga ƙananan ƙananan zuwa lalacewa. Saboda yawancin wadannan alamun sunaye ne a FMS da ME / CFS, zaka iya kuskuren su saboda alamun rashin lafiyar rashin lafiyarka da suke karuwa yayin da kake shan magani. Tuntuɓi likitan ku idan kuna da damuwa.

Wasu abubuwa na iya taimakawa wajen kawar da bayyanar cututtuka. Za ka iya koya game da su a cikin wannan labarin daga matsala ta ciki: Tips don Rage ƙusar cututtukan cututtuka

Risks: Hanyoyin Hanya & Harkokin hulɗa

Wadannan kwayoyi sun zo tare da jerin dogaro masu tasiri. Wasu daga cikin haɗari masu haɗari sun haɗa da kamawa, hallucination da kuma ayyuka marasa ƙarfi.

SSRIs / SNRIs zasu iya hulɗa da kyau tare da kwayoyi ba tare da wadanda ke ƙara serotonin ba. Wadannan zasu iya haɗawa da anti-inflammatories (NSAIDs), masu zubar da jini, da sauransu.

Hanyoyi masu tasiri da hulɗar juna sun bambanta da miyagun ƙwayoyi. Don bincika takamaiman kwayoyi, zaka iya duba su a Drugs.com ko RxList.com. Suna kuma ma samuwa a cikin buƙatun bayani.

Ragewar Hadarinku

Hanyar da ta fi dacewa don rage halayen da ke hade da SSRIs / SNRIs shine kulawa da hankali ga umarnin likitanku da likitan magunguna don maganin jigilar magunguna. Idan akwai gaggawa, za ka iya so ka ajiye lissafin magunguna a cikin walat.

Zai iya taimakawa wajen buga jerin abubuwan da zasu iya haifar da halayen ka kuma kiyaye su a wani wuri na bayyane, musamman lokacin da ka fara sabon magani. Ta wannan hanyar, za ku iya ganin sauri ko sabon bayyanar cututtuka da kuke fuskantarwa na iya haɗawa da miyagun ƙwayoyi.

Shin SSRIs / SNRIs daidai ne a gare ku?

Shawarar ku dauki SSRIs ko SNRIs mafi kyau ya sanya ku da likitan ku, yayin da kuke la'akari da bincikar ku, alamun cututtuka, lafiyar lafiyar ku, da abubuwan rayuwa.

Kila iya buƙatar gwada kwayoyi da yawa a cikin wannan aji kafin ka sami wani aiki da ke aiki da kyau donka kuma zaka iya jurewa. Wannan na iya ɗaukar lokaci mai yawa. Tabbatar kiyaye layin sadarwa tare da likitanku a yayin wannan tsari.

_Sources:

_{Arnold LM, et al.} _{Jaridar asibiti ta ciwo.} _{2009 Yuli-Aug 25 (6): 461-8.} _{Haɗakar da inganci da aminci na duloxetine don maganin fibromyalgia a cikin marasa lafiya tare da ba tare da matsala masu ciwo ba.}

_{Choy EH, et al.} _{Clinic rheumatology.} _{2009 Satumba 28 (9): 1035-44.} _{Tsaro da jurewa na duloxetine a maganin marasa lafiya tare da fibromyalgia: bincike na bincike akan bayanai daga jarrabawar gwaji biyar.}

_{Derry S, et al.} _{Cochrane database na dubawa tsarin.} _{2012 Mar 14; 3: CD008244.} _{Milnacipran na ciwon neuropathic da fibromyalgia a cikin manya.}

_{NIH Publication NO.} _04-5326.

_{Nishiyori M, et al.} _{Maganin kwayoyin cutar.} _{2011 Sep 21; 7: 69.} _{Aminci na har abada daga matsanancin sanyi mai tsanani - haifar da fibromyalgia-kamar irin ciwo mai ma'ana ta hanyar magungunan maganin antidepressants.}

_{Saxe PA, et al.} _{Binciken likita na yanzu da ra'ayi.} _{2012 Mar 19. Tsarin lokaci (2-Week) Hanyoyi na katse Milnacipran a cikin marasa lafiya da Fibromyalgia.}

_{Cibiyar Abinci da Drug.} _{"Rayuwa tare da Fibromyalgia" An shiga Maris 2012.}

_{Warner, Christopher H, et al.} _{Aminiya na Yammacin Amirka.} _{2006 Aug 1, 74 (3): 449-56.} _{Abun ciwo na rashin ciwo ta antidepressant.}