Magungunan ƙwayar cuta na iya yin amfani da Gene Generating Trigger Muscle Pain
Statins su ne rukuni na cholesterol-ragewan magunguna da ke aiki ta hanyar hana wani sinadarin maɓalli, HMG-CoA reductase, wanda ke da alhakin yin cholesterol a cikin hanta. Wadannan kwayoyi suna da tasiri a rage rage ƙwayar cuta da ciwon zuciya.
Miliyoyin Amirkawa sun ɗauki statins saboda sun dace da dukkan nau'ikan ɓangaren ku na lipid ta hanyar rage LDL cholesterol da triglycerides yayin kiwon HDL cholesterol.
Duk da haka, kamar magunguna masu yawa, akwai tasiri mai tasiri.
Hanyoyi masu lahani na statins sun haɗa da:
- ciwon tsoka kamar yadda ya fi dacewa
- haɓaka a samar da enzymes a cikin hanta a matsayin sakamako na lokaci-lokaci
- tsoka da hanta lalacewa kamar yadda wani sakamako mai tasiri
- matsaloli masu narkewa, ciki har da gas, zazzaɓi ko tashin hankali, a matsayin sakamako mai mahimmanci
- karuwa a cikin jini, wanda zai iya haifar da ciwon sukari mai tasowa irin na 2, ƙananan, amma yiwuwar hadarin
- Abubuwan da ke haifar da tasiri, ba tare da ƙwaƙwalwar ƙwaƙwalwar ajiya ba, shi ne gargadi daga Cibiyar Abinci da Druggun Amurka da ta bayyana a kan takardu na statin
Hanyoyin Wuta na Labaran shi ne Cutar Muscle
Kimanin kashi 5 zuwa 10 cikin dari na marasa lafiya da ke ɗauke da kwayoyin sunyi tasiri mai mahimmanci, wanda ya fi yadda rahoto na asali. Kwayar cututtuka na iya bayyana a farkon watanni shida na jiyya ko bayyana bayan shekaru da yawa.
Lokacin da ya faru da ciwo na muscular, sakamakon illa na iya jingina daga rauni mai tsoka ga barazanar rhabdomyolysis , wanda yake da wuya.
Rashin haɗarin lalacewar tsoka yayin da kake daukar nau'o'i sun dogara da dalilai masu yawa, ciki har da:
- kasancewa fiye da 80, mata, ko kuma bakin ciki
- shan ruwan ganyayyaki
- dadi ko maye gurbin barasa
Wani binciken da aka wallafa a cikin shekara ta 2016 na New England Medical Journal ya nuna magungunan yaduwar kwayoyin halitta da aka haifa a cikin asalin sunada magungunan statins.
Wannan mummunan ƙwayar tsoka yana da wuya kuma yana faruwa a cikin wani ɓangare na marasa lafiya.
Dalili Dalili Me yasa Labaran Da ke Safarar Raɗaɗi?
Nazarin da ya gabata ya nuna cewa kwayar halittar atrogin-1 tana farawa a farkon matakai na raunin tsoka (ƙuƙwalwar tsoka), wanda ke haɗuwa da cututtuka irin su ciwon daji , sepsis , da AIDS . Lokacin da ragowar inrogin-1 ba ta aiki ba, ƙwaƙwalwar ƙwayar cuta ba ta faruwa.
Masana kimiyya a Bet Israel Cibiyar Kimiyya ta Deaconess a Boston, Massachusetts sun ji cewa atrogin-1 na iya taka muhimmiyar rawa a ci gaba da maganin halittu masu rai a cikin wadanda ke daukar kwayoyin. Don gwada wannan, masu binciken suka ba da wani statin, Mevacor (lovastatin) , ga sel tsohuwar jiki, kifi na Zebra, da mutane.
Masu bincike sun gano cewa mutane suna daukar lovastin suna da matakan da suka fi girma fiye da waɗanda ba su shan magani ba. Yawancin Mevacor da aka ba wa kwayoyin da kifi na Zebra, mafi kusantar shi ne lalacewar tsoka zai faru. Lokacin da aka cire anrogin-1 daga cikin kwayoyin halitta, magani bai haifar da lalacewar tsoka ba.
Wannan bayanin shine na farko, amma yana ba mu fahimtar abin da zai iya haifar da mummunan tsoka a cikin masu amfani da statin, kuma dalilin da yasa wasu mutane da ke ɗauke da magungunan na iya zama mafi sauki ga wannan fiye da sauran.
A nan gaba, wannan zai iya bada izinin mai kula da lafiyarka don gano idan kana cikin haɗari ga myopathies na statin, wanda ya kasance daga mummunan tsoka mai tsoka ga rhabdomyolysis na rayuwa .
Bugu da ƙari, masana kimiyya zasu iya sarrafa wannan jinsin, ko kuma wasu da ke ciki, don hana lalacewar tsoka ta hanyar statins.
Sources:
Hanai JI, Cao P, Tanksale P, et al. Musamman-ƙananan liquse liquse atrogin-1 / MAFbx na haifar da mummunan ƙwayar tsoka ta jiki. J Invest Invest. 117 (12): 3940-3951.
Mammen, Andrew. Jaridar New Medicine na Ingila ta New England: Stats-Associated Autoimmune Myopathies (2016)
Ciwon Mayo: Matsayin Farko na Statin - Nauyin Amfani da Risks (2013)