Magunguna, waɗanda aka yi amfani da su don rage yawan cholesterol , suna daga cikin magungunan da aka fi sani da su a duniya. Duk da yake yawancin mutum yana da kyau sosai, yawancin cututtukan da sukafi tasiri sun danganci ƙwayar ƙwayar cuta, yanayin da ake kira "statin myopathy".
Mene ne alamun cututtuka na Statin Myopathy?
Statin myopathy yana daukan daya daga cikin nau'i uku:
- Myalgia - ciwon tsoka - an samu ta hanyar 2% zuwa 10% na mutanen da ke daukar kwayoyin. Rikicin myalgia ne mai tsanani ya kasance kamar ciwo, yawanci a cikin kafadu da makamai, ko hips da thighs. Ana sau da yawa tare da rauni mai rauni.
- Myositis - ƙwayar ƙwayar tsoka - yana faruwa a game da mutum daya a cikin mutane 200 da ke dauke da kwayoyin. Myositis yana sa ciwon tsoka, da maɗaukaki a CK matakan cikin jini. CK wani ƙwayar ƙwayar tsoka ce, kuma kasancewa a cikin jini yana nuna cewa ainihin lalacewar tsoka yana faruwa.
- Rhabdomyolysis yana da mummunan ciwo mai rauni - ainihin mummunan rauni na tsoka - wanda zai haifar da babban suturar furotin ƙwayar jiki a cikin jini, wanda zai iya haifar da lalacewar koda da mutuwa. Rhabdomyolysis da lalacewa ta hanyar statins, da sa'a, yana da wuya sosai, tare da sau ɗaya yanayin faruwa ga kowane takardun statin miliyan 10 da aka rubuta.
Idan matsalolin muscle na faruwa, sukan fara a cikin 'yan makonni zuwa wasu' yan watanni bayan farawa na statin.
Myalgia da kuma myositis sunyi kokarin warwarewa a cikin 'yan makonni idan an dakatar da farfitaccen statin. Rhabdomyolysis zai warware bayan da aka dakatar da statin, amma lalacewar da ta haifar ba zai yiwu ba.
Duk da yake akwai dabaru da yawa, babu wanda ya san dalilin da ya sa statins zai iya haifar da matsaloli na tsoka.
Zai yiwu mai yiwuwa myopathy ya yi da canje-canje a yadda yadda tsokoki ke samar ko yin amfani da makamashi. Ya zuwa yanzu, masu bincike ba su iya daukar nauyin da yawa fiye da wannan ba tare da amincewa da kowane mataki.
Ka'idar da ta sami karfin hali tare da jama'a shi ne cewa wadannan kwayoyin zasu iya tsangwama tare da samar da CoQ10, coenzyme a cikin tsokoki. CoQ10 yana taimaka wa tsokoki amfani da makamashi da suke bukata don aiki. Wasu ƙananan binciken sun nuna cewa yin amfani da kariyar CoQ10 zai iya rage yawan tasirin tsoka na tsofaffin kwayoyin, amma bayanan (duk a kan ko tsararrakin da za su rage matakan CoQ10 da kuma ko goyon bayan CoQ10) yana da rauni sosai.
Binciken da aka yi kwanan nan ya nuna cewa matsalolin tsoka da statins sun fi sau da yawa a cikin mutanen da ke da raunin bitamin D. Wasu sun gano cewa yin amfani da bitamin D ga waɗannan mutane zai taimaka wajen magance cututtukan ƙwayoyin tsoffin jikinsu.
Abubuwan Dama don Faɗar Matsala
Matsalolin ƙwayoyin cuta tare da statins sunfi kowa a cikin mutanen da suke daukar Lopid (gemfibrozil) , steroids, cyclosporine, ko niacin.
Mutanen da ke fama da cutar koda, cututtukan hanta, rage yawan bitamin D, ko hypothyroidism kuma sun fi kuskure su fuskanci matsaloli na tsoka da statins, kamar yadda mutanen da ke da tsohuwar ƙwayar tsoka kamar amyotrophic laral sclerosis (ALS) .
Wasu sharuɗɗa sun bayyana mafi kusantar samar da matsaloli na tsoka fiye da wasu. Musamman ma, abin da ke faruwa na ƙwayar tsoka zai iya zama mafi girma tare da simvastatin (mai suna Zocor) fiye da sauran kwayoyi.
Saboda wannan dalili, a Yuni 2011, Cibiyar Abinci da Drugta ta bada shawarar cewa kashi kashi na simvastatin zai iyakance ga 40 mg kowace rana. A wannan nauyin, rashin lafiyar ƙwayar tsoka da simvastatin ba ya zama mafi girma.
Rashin hadarin matsalolin tsoka yana da mahimmanci tare da Lescol (fluvastatin), Pravachol (pravastatin) kuma tabbas Crestor (rosuvastatin). Idan milan lalacewar tsofaffin ƙwayoyi na faruwa tare da wasu statins, sauyawa zuwa ɗaya daga cikin wadannan kwayoyi zai iya warware matsalar nan gaba.
Stopin myopathy yana da ɗan lokaci a cikin mutane da suka shiga aikin motsa jiki, musamman ma idan sunyi haka ba tare da gina shi ba a hankali.
Yaya Zamuyi Amfani da Matsala na Muscle Cikin Jima?
Kullum, idan an yi la'akari da matsala mai tsoka akan static, likitoci zasu dakatar da maganin magunguna, akalla har sai matsalar muscle ta warware. Dole ne a yi nazari don rashin daidaituwa na bitamin D da hypothyroidism, da kuma duk wani hulɗa da kwayoyi wanda zai iya kara yawan matsalolin tsoka na statin. Dukkanin wadannan matsalolin da aka gano zasu kamata a tattauna.
Idan bayyanar cututtuka na tsoka ta ƙunshi kawai ciwo da watakila karamin tayi a cikin matakan jini na CK, kuma idan ci gaba da farfadowa na statin ya zama mahimmanci, akwai wasu hanyoyi da zasu iya ba da izini ga cigaba da cigaban statin.
Na farko, sauyawa zuwa wani statin wanda ba zai yiwu ya haifar da matsaloli na tsoka ba (irin su pravastatin ko fluvastatin) zai iya ba da izini ga mutumin da ke da tsohuwar ƙwayoyin tsoka ta hanyar yin amfani da statin. Har ila yau, ba da umarnin yin amfani da maganin magunguna a kowace rana, maimakon kowace rana, ya taimakawa wasu mutanen da basu iya jurewa tsarin likita na yau da kullum ba. A ƙarshe, yayin da mafi yawan masana basu yarda cewa goyon bayan CoQ10 yana taimakawa wajen sake dawowa da farfadowa na statin ba, akwai rahotanni da aka watsa cewa wannan zai taimaka.
Kalma Daga
Duk da yake illa mai lalacewa shine matsalar da tafi dacewa da aka gani tare da statins, waɗannan cututtuka masu tasiri sun kasance marasa dacewa a cikin mutanen da ba su da ƙarin abubuwan haɗari. Bugu da ƙari, kuma lokacin da suke faruwa, matsalolin muscle kusan kusan kullun. Matsalolin tsoka da ke rayuwa masu rai suna da ban mamaki.
Duk da haka, idan kana shan maganin magungunan statin ya kamata ka kasance da sanin yiwuwar tasowa tsofaffin tsoka ko rauni, kuma idan wadannan bayyanar cututtuka ya faru ya kamata ka kawo su zuwa ga likitanka.
> Sources:
> Gupta A, Thompson PD. Dangantakar Damar Darin Darin Darin Darin Darin Darin Darin Darin Darin Darin Dama Atherosclerosis 2011; 215: 23.
> Rosenson RS, Baker SK, Jacobson TA, et al. Binciken da Ma'aikatar Tsaro ta Musamman ta Bincike: 2014 sabuntawa. J Clin Lipidol 2014; 8: S58. T
> Stroes ES, Thompson PD, Corsini A, et al. Magungunan cututtukan ƙwayoyin cuta na Statin: Impact on Statin Far-European Atherosclerosis Society Consensus Panel Magana akan Bincike, Aiki da kuma Gudanarwa. Eur Heart J 2015; 36: 1012.
> Thompson PD, Clarkson PM, Rosenson RS, Ƙungiyar Ma'aikata na kasa da kasa Kungiyar Tsaro ta Tsaro ta Muscle Safety Expert Panel. An Yi Nazarin Tsaro Mai Girma ta Masanan Musamman. Am J Cardiol 2006; 97: 69C.