Amfani da Shaidun da ke Kula da Farfesa
Cutar immunoglobulin (IVIG) mai ciki shine wani nau'i na farfadowa wanda ake amfani da cakuda kwayoyin cutar (immunoglobulins) a cikin wani nau'i tare da manufar inganta aikin rigakafin mutum. Magunguna su ne kare sunadarai waɗanda jiki ya samar don magance cutar.
An yi amfani da IVIG don aiki a cikin cututtukan da ba a kwakwalwa ba ta hanyar motsa wasu sassa na tsarin rigakafi da kuma kashe wasu.
Ba wanda ya san yadda yake aiki, kuma, kamar yadda irin wannan, an rubuta IVIG akan lakabin-lakabin (ba tare da amincewar FDA ba) don cututtuka wanda tsarin kulawar rigakafi na mutum ya ƙaddara.
Wadannan zasu iya haɗawa da siginar neonatal, HIV / AIDS, da wasu lokuta na HIV . Ana amfani da ita azaman magani na biyu don magani a sake dawowa-maido da ƙwayar sclerosis (RRMS) .
Amfani da IVIG a Multiple Sclerosis
An yi amfani da IVIG a ƙwayoyin sclerosis (MS) don rage ci gaba da cutar kuma ta rage yawan nakasar da cutar ta haifar. Duk da yake babu wata yarjejeniya ta musamman game da lokacin da IVIG ta fi dacewa, to, ya nuna alkawurra a wasu wurare da dama:
- Tsayar da MS sake dawowa a cikin haihuwa
- Yin maganin mutanen da suka kasa yin magani na farko don RRMS kuma basu iya jure wa maganin cututtukan gargajiya na gargajiya ba
- Yin maganin MS na gaba gaba (ko da yake akwai sauran muhawara game da ingancinta)
Wasu nazarin sun nuna cewa samfurin da aka ba da shi a lokacin bayyanar cutar ta farko na MS (da ake kira ciwon ƙwayar ƙwayar cuta, ko CIS ) na iya rage damar da mutum yayi na musanya zuwa ganewar asali na MS. Mafi yawan wannan binciken ya kuma hadu da rashin shakku ko rashin shakka.
Amfani da IVIG
A wannan lokacin, babu wanda ya san yadda tasiri na IVIG ke aiki ko rage jinkirin MS.
Yawancin shaidun da aka samo asali ne akan tasirinsa akan wasu cututtuka na jiki, irin su ciwon guillain-Barré da na myasthenia gravi s. Nazarin da aka mayar da hankali akan IVIG da MS sun haɗu da kyau.
Ɗaya daga cikin nazarin binciken Australiya ya nuna karamin ci gaba a cikin rashin lafiya kamar yadda aka auna ta hanyar ƙwarewa (EDSS) . Wasu sun nuna karamin cigaba a girman ko yawan ƙwaƙwalwar ƙwayar cuta a kan MRI.
Sauran, a halin yanzu, ba su nuna bambanci a tasiri na IVIG ba idan aka kwatanta da wuraren da suke kula da RRMS.
Wataƙila wannan yanki na alkawari shi ne yin amfani da IVIG daidai bayan haihuwa, aikin da ya nuna ya rage ragowar komawa cikin iyaye mata.
Dosage da Gudanarwa
Yayin da ba a kafa magungunan na RRMS ba, yawancin masu rubutun suna bayar da shawara ga sashi na guda ɗaya na kilogram na nauyin jiki wanda aka ba kowane wata. Wasu za su tsara nauyin 400 mg / kg kowace rana a kan kwanaki biyar.
Hanyoyin Gaba
Sakamakon sakamako mafi girma na IVIG shine ciwon kai (wanda za'a iya kulawa da shi tare da magunguna masu yawa kamar Tylenol). Sauran cututtuka masu illa sun hada da zazzabi, ciwon haɗin gwiwa, zafi ciwon ƙirji, da zubar da ciki. Kadan ƙari, haɗuwa da miyagun ƙwayoyi suna iya bunkasa.
Wasu mawuyacin cututtukan da suka faru sun faru, ciki har da meningitis , cututtukan zuciya, bugun jini, ciwon zuciya mai zurfi, ƙwayar koda, da gazawar koda.
Harkokin hulɗa da Contraindications
Ba za a yi amfani da IVIG ba a cikin mutane da matsaloli na koda ko rashi IgA (cututtukan kwayoyin halitta da rashin rashin lafiya wanda ke karewa daga cututtuka a cikin bakin, kullun jiragen sama, da kuma hanyoyin narkewa). A
A halin yanzu, ya kamata a yi amfani da IVIG da hankali a cikin mutane da:
- Matsalar zuciya
- Ciwon sukari
- Sensitivity zuwa immunoglobulins
- Sensitivity to maltose or sucrose (sinadaran amfani da wasu IVIG formulations)
Abinda ke da dangantaka da IVIG kawai ya ƙunshi alurar riga kafi. Immunoglobulins zai iya yin maganin alurar rigakafi da rashin amfani da duk wani kariya ta maganin alurar riga kafi.
Kudin Kulawa
IVIG ya zama tsada mai tsada a kimanin dala 100 a kowace gram. Don mutum yana kimanin kilo 154 (kilogram 70), samfurin da aka ba da shawarar kowane asali zai kawo kimanin kimanin $ 7,000 a kowace jiko, ba tare da haɗin ginin da kuma kulawa ba.
Wasu kamfanonin inshora suna iya ɗaukar kuɗin, amma sau da yawa wuya a motsa su don magani kuma yawanci suna buƙatar aiwatar da takaddama don samun amincewa. Idan an yarda, asusun inshora yana iya zama mai girma. Duk da haka, wasu masu sana'a na IVIG suna bada shirye-shiryen taimako na haƙuri (PAPs ) zuwa ko dai suna kare dukiyar kudi.
Kalma Daga
Idan ana bada shawara na IVIG, zaka iya buƙatar yin shawara don kanka don samun amincewa daga inshora naka. Da wannan aka ce, yana da mahimmanci mu fahimci amfanin da ƙuntatawa da maganin da aka tsara - musamman abin da binciken ya gaya mana kuma bai gaya mana ba.
Idan baku da cikakken bayani game da wannan, kada ku yi shakka ku nemi ra'ayi na biyu daga likita.
> Sources:
> Bayry, J. Hartung, H .; da kuma Kaveri, S. "IVIg don sake sakewa-daɗawa da yawa sclerosis: alkawura da rashin tabbas." Trends Pharm Sci. 2015; 36 (7): 419-421.
> Gilardin, L ;; Bayry, R .; da kuma Kaveri, S. "Immunoglobulin mai tsanani kamar ƙwayoyin marasa lafiya." CMAJ. 2015; 187 (4): 257-264.