Yanayin IgA Zaɓi
Rashin daidaituwa na immunoglobulin A (IgA) shine mafi yawan rashin daidaituwa ta farko. An bayyana shi da rashin ƙarfi ga matakan IgA ba a cikin jini, wanda zai iya haifar da adadin yawan cututtuka wanda ya ƙunshi jikin mucous, irin su kunnuwa, sinuses, huhu da kuma gastrointestinal tract. Mutanen da ke dauke da raunin IgA suna cikin haɗarin ƙwayar cututtuka, ciki har da cututtuka na asibiti, cututtuka na gastrointestinal, cututtuka masu rashin lafiyar, da kuma cututtuka na rashin daidaituwa.
Menene IgA?
IgA shine mafi yawan kwayoyin cutar da jiki ya samar da shi kuma yana cikin duka jini da kuma a cikin ɓoyayyen tsari a kan fuskokin mucous. Matsayi mafi mahimmanci na IgA shi ne kare kariya daga kamuwa da cuta daga kwayoyin da yawa wadanda suke a jikin mucous membranes. IgA yayi aiki don ɗaukar nauyin kwayoyin cuta, wanda za'a lalace ta hanyar dabarun tsari.
Mene ne rashin lafiya na IgA?
Yawancin IgA an bayyana shi azaman cikakkiyar nauyin, ko ƙananan ƙananan dabi'u, na IgA kamar yadda aka auna a cikin jini, a wurin kafa wasu matakan antibody ( IgG da IgM) kasancewa na al'ada. Matsanancin ƙimar IgA ba su dace da rashi IgA.
Duk da yake an rarraba rashi IgA a matsayin nau'i na rashin daidaituwa, 85-90% na mutanen da ke dauke da IgA basu da alamun alaƙa da suka shafi yanayin su. Yawancin mutane ana bincikar su ne sakamakon jinin jini, wanda kimanin 1 a cikin 300 mutane ana samun ladaran IgA.
Lalacin IgA yana haifar da ciwo mai ciwo na wasu kwayoyin jini mai tsabta a jikin jiki ( B-sel da / ko T-cell ), wanda yawanci ne saboda cututtuka na kwayoyin dake gudana a cikin iyalai.
Mene ne alamun ilimin IgA?
Wasu, amma ba duka ba, mutane masu fama da IgA suna fuskantar haɗari ga cututtuka wanda ya ƙunshi ƙwayoyin mucous, irin su sinusitis , kunnuwan tsakiya ( maganin otitis ), huhu ( ciwon huhu ), da kuma gastrointestinal tract (Giardiasis).
Ba a fahimci dalilin da yasa yawancin mutanen da ke dauke da IgA ba su da karuwa a cikin cututtuka, kuma me yasa wasu suna da matsaloli masu yawa daga wannan rashin kuskure.
Lalacin IgA ma yana hade da wasu cututtuka na gastrointestinal, ciki har da rashin haƙuri na lactose , cutar celiac , da kuma cututtukan ulcerative colitis. Celiac cutar mafi yawancin bincikar shi ne ta wurin kasancewa da kwayoyin IgA akan wasu sunadarai a cikin gastrointestinal tract, wanda, ba shakka, ba zai samu ba a cikin mutumin da ke dauke da cutar Celiac da kuma IgA. Maimakon haka, kamuwa da kwayoyin IgG a kan waɗannan sunadaran sun kasance a cikin mutumin da ke fama da cutar celiac. Saboda haka, mutum wanda ake zargi da ciwon cututtukan Celiac ya kamata a binciki rashi IgA a lokacin gwajin jini don cutar ta Celiac don tabbatar da cewa gwaji na al'ada don cutar celiac ba zai zama sakamakon mummunan sakamako sakamakon sakamakon IgA ba.
Yawancin bincike sun nuna cewa akalla rabin mutanen da ke dauke da lakabi IgA suna da yawan ƙananan yanayin rashin lafiya, ciki har da ciwon hay , fuka , eczema , hives da rashin abinci . Wasu mutane tare da raunin IgA suna haifar da cututtuka ( IgE ) tare da kwayoyin IgA kuma saboda haka suna kara yawan haɗarin anaphylaxis sakamakon sakamakon karbar jini.
Sabili da haka, mutanen da ke dauke da IgA ya kamata su yi amfani da makamai na farfadowa na likita don haka idan an yi amfani da jini na gaggawa gaggawa, za a iya amfani da samfurin jini wanda ba shi da yaduwar cutar IgA don rage yawan damar anaphylaxis.
Mutane masu fama da cutar ta IgA suna ci gaba da haɗari ga cututtuka daban-daban, ciki har da wasu cututtuka na jini (irin su ITP , TTP, anemia na jini), arthritis na rheumatoid, tsarin lupus erythematosus , da thyroiditis na Hashimoto. Wadannan cututtuka sun faru a kimanin 20-30% na mutane tare da rashi IgA.
Wasu cututtuka, musamman magungunan gastrointestinal da lymphomas , kuma suna faruwa a mafi girma a cikin mutanen da ke cikin IgA.
A ƙarshe, wasu mutane tare da raunin IgA na iya ci gaba da ɓarna ƙananan nau'i na rashin daidaituwa, irin su rashin ƙarfi marar iyaka (CVID).
Mene ne magani ga IgA rashin daidaituwa?
Babban maganin raunin IgA shine maganin cututtuka ko cututtukan da ke haɗuwa da zasu iya faruwa. Ya kamata mutanen da ke fama da lakaran IgA da kuma ciwon da aka ci gaba da bi da su a baya da kuma mafi tsanani tare da maganin rigakafi fiye da wani ba tare da rashi IgA ba. Dole ne a hana rigakafin rigakafi da cututtuka na kowa, irin su tare da fashewar cututtuka (maganin rigakafi mai maganin maganin maganin rigakafi) na maganin alurar rigakafi da kuma maganin pneumococcal , ya kamata a bai wa mutanen da ke cikin IgA. Kulawa akan abin da ke faruwa na cututtukan cututtuka, da cututtukan gastrointestinal, yanayin rashin lafiyar, cututtuka, da damuwa rashin daidaituwa ya kamata a yi a hankali ga mutanen da ke dauke da IgA.
Source:
Yel L. Zaɓaɓɓen Ƙimar IgA. J Jarin Immunol. 2010; 30: 10-16.
DISCLAIMER: Bayanan da ke cikin wannan shafin shine don dalilai na ilimi kawai, kuma kada a yi amfani dashi a maimakon maye gurbin likita mai lasisi. Don Allah a duba likita don ganewar asali da kuma magance duk wani abu game da bayyanar cututtuka ko yanayin lafiya.