Ta Yaya Mayan Statut Zai shafi Mutane da Ciwon Cutar Lung?
Magungunan ƙwayar cuta da ciwon huhu
Kuna iya jin cewa kwayoyin magunguna zasu iya inganta lafiyar cutar kanjamau, taimakawa tare da magani, ko cutar ƙwayar cutar ciwon huhu. A cikin dukkanin wannan nau'i, menene binciken ya nuna? Shin suna magana ne game da hana ciwon huhu na huhu kafin ya fara, ko maganin cutar kanjamau bayan ya riga ya kasance? Shin irin kwayar cutar ciwon huhu ne kuma yana damuwa abin da wasu jiyya kake amfani dasu?
Masana kimiyya sukan yi mamakin lokacin da magani akan yanayin daya ya bayyana don taimakawa ga yanayin da ba tare da dangantaka ba. Statins kwayoyi na iya zama daya daga cikin wadannan jiyya. Wadannan magungunan da suka rage cholesterol a tsakanin sauran ayyuka su ne wasu daga cikin kwayoyi masu yawan gaske a duniya. Masu bincike sun dauki karin sha'awar wadannan kwayoyi a cikin 'yan shekarun nan bayan sun ga dangantakar dake tsakanin amfani da wadannan kwayoyi da ciwon daji.
Menene Statins?
Statins su ne nau'i na magunguna da aka sani da masu hana HMG-CoA reductase. Yayinda jama'a ke kallon wadannan kwayoyi kamar "ƙwayoyin cholesterol ragewan kwayoyi" ainihin ma'ana shine rage yawan hadarin zuciya. Bugu da ƙari ga rage ƙwayar cholesterol, waɗannan kwayoyi sun karfafa ma'aunin kwakwalwa a cikin jigilar jini , rage yawan adadi a cikin jigilar jini, da kuma rage yaduwar jini a cikin jigilar jini. Saboda haka, statins zai iya rage yawan haɗarin haɗari har ma da cholesterol na al'ada.
A gefe ɗaya na ƙayyadaddun, maganin ƙananan ƙwayar cholesterol kadai - sai dai idan ya haifar da bambanci a lafiyar da rayuwa - ba burin manufar statin ba.
Ta yaya Dokokin Tsaro zasu shafi Ciwon Canji?
Nazarin dabbobi da nazarin salula (kallon kwayoyin cututtuka da aka girma a cikin tanda) sun nuna cewa statins suna da magungunan ciwon daji.
An yi tunanin cewa zasu iya toshe kwayar cutar kwayar tumɓir, mamayewa, da kuma yiwuwar ciwon daji don yaduwa (metastasize.)
Bisa ga ƙungiyar masu bincike, statins da suka fi yawan rubophilic (mai-mai mai) zasu kasance mafi tasiri. Ƙarin lipophilic statins sun hada da Lipitor (atorvastatin), Zocor (simvastatin), da Mevacor (lovastatin). Ƙananan lipophilic (mafi kyawun hydrophilic ko "ƙarancin ruwa") sun hada da Pravachol (pravastatin), Crestor (rosuvastatin), da Lescol (fluvastatin).
Ciwon Lafiya da Ciwon Kankara da Ciwon Kankara
Wani bincike na baya-bayan nan ya nuna cewa mutanen da suke daukar kwayar magungunan rigakafi kafin ko bayan ganowar cutar kanjamau na iya samun ƙarin yawan rayuwa.
A cikin wannan binciken na kimanin mutane 14,000 da ke fama da ciwon huhu a cikin Birtaniya tsakanin 1998 zuwa 2009, mutanen da ke amfani da kwayar magungunan kwayar cutar kafin su gane asali suna da kashi 12 cikin dari na rage yawan cutar mutuwar mahaifa.
Ga wa] anda suka yi amfani da maganin magungunan statin bayan sun gano asali , kuma sun rayu na akalla watanni 6, akwai raguwa mai mahimmanci a cikin cutar kanjamau - musamman mutuwar kashi 11 cikin 100. Ga waɗanda suka cika alkawarinsu a kalla sau 12 (amfani da shekara guda ko fiye), akwai raguwa mai mahimmanci a cikin ciwon daji na huhu-takamaiman mutuwar kashi 19 cikin 100.
Wannan binciken ya shafi mutanen da ke fama da cutar ciwon huhu da kananan kwayoyin marasa lafiya da kananan kwayoyin cutar kanjamau kuma ya fassara zuwa marasa lafiya da ke fama da cutar kanjamau 3,638 wanda ke da ƙananan ƙwayar cutar ciwon huhu-musamman mace-mace. Idan waɗannan lambobin sun shafi yawancin mutanen da ke fama da ciwon huhu na huhu, wannan ba zai zama karami ba, tun da an sa ran mutane 158.040 zasu mutu daga ciwon huhu a cikin 2015 a Amurka kadai. A matsayin gwadawa mai sauri, kimanin mutane 3,000 suka mutu a cikin wutar da ke cikin gida a Amurka a kowace shekara.
Yana da mahimmanci a lura cewa wannan bincike ne da wuri , kuma ba za mu iya tabbatar da cewa kwayoyin magunguna ne suke haifar da ragowar mutuwar ba .
Alal misali, akwai wasu matakan (wani canji) a cikin mutanen da suke amfani da kwayar magungunan statin da aka danganta da ingantaccen rayuwa.
Statins da Ciwon Cutar Cancer Mortality
Binciken binciken da aka wallafa ta watan Afrilu na shekara ta 2015 (binciken 41) yana duban tasirin da ake samu akan yawan ciwon daji, yana nuna goyon baya ga ra'ayin cewa statins zai iya shafar cutar kanji. Wadannan nazarin, wanda ya shafi kusan mutane miliyan daya, ya nuna cewa yin amfani da statins bayan ganewar cutar ciwon daji yana da nasaba da kashi 19 cikin dari na yawan mace-mace da kuma kashi 23 cikin dari na mace-mace. Ƙarshen binciken da masu bincike ke kallon waɗannan nazarin shine cewa "amfani da kwayoyin kafin su kuma bayan ganewar asali yana da mahimmanci ga rayuwa da ciwon daji na musamman." Yana da muhimmanci a lura da cewa cutar kanjamau ne kawai a baya a cikin wadannan nazarin, tare da ci gaba da nazarin ilimin nono, ciwon daji, da ciwon daji.
Hanyoyin Statins a kan Ciwon Cutar Cancer
Ba a san yawan yadda shafuka ke shafar maganin mutum don ciwon daji ba, amma karamin karamin bincike ya gano cewa ƙara statin ga magunguna kamar Tarceva ya haifar da cigaba da cigaba a rayuwa mai ci gaba ba tare da marasa lafiyar mahaifa ba don maye gurbin KRAS. Wannan labarin ya tattauna gwajin gwaji ga mutun da ke fama da ciwon huhu na huhu .
A al'ada, mutanen da suka gwada tabbatacce ga maye gurbin KRAS ba su dace da magunguna da ake kira epidermal growth factor mai karɓar tyrosine kinase ( EGFR-TKIs ) ba. Magunguna a cikin wannan rukuni (maganin kwantar da hankali) da aka yi amfani da shi a cikin ciwon huhu na huhu shine Tarceva (erlotinib) da Iressa (gefitinib). A cikin mutanen da ke da mataki 3B da mataki na 4 marasa ciwon kwayar cutar kwayar cutar ta jiki don tabbatacciyar KRAS, adadin statin ya ninka tsawon rayuwar tsira.
Binciken da aka yi a kan kwayoyin cutar kanjamau na mutane sun gano cewa ƙara wani statin ya hana kwayoyin cutar kanjamau. A taƙaice, anyi zaton cewa statin yana haifar da raguwa a cikin hadoprenoids wanda ke da tasiri akan RAS - saboda haka yana da tasiri a kan kwayoyin cutar kanjamau a cikin jiki tare da maye gurbin KRAS.
Ciwon daji da ƙwayar cutar ciwon huhu
Yayin da karamin binciken da aka riga ya fara ba ta gano hanyar haɗin kai tsakanin statins da rigakafi na huhu ba, binciken da aka yi kwanan nan a Taiwan ya nuna tasiri sosai, musamman ga mata, musamman ma wadanda ke da sauran cututtuka irin su COPD da tarin fuka . Masu bincike sun kwatanta da mata 17,000 ba tare da ciwon huhu ba tare da mambobin mata 17,000 waɗanda aka gano da ciwon huhu tare da ciwon huhu a tsakanin shekara ta 2005 da 2010. Anyi amfani da Zocor (simvastatin) na tsawon lokacin da aka kwatanta da mata da ba su yi amfani da su ba. magani. Amfani da Mevacor (lovastatin) na dogon lokaci ba, duk da haka, ba tare da haɗarin cutar ba.
Koyi game da rikice-rikice na kwanan nan game da amfani da statins a cikin mata .
Menene Ya kamata Ka Yi da Wannan Bayanin?
Kamar yadda muka gani a sama, wannan binciken yana cikin jariri, kuma ba a sanya shawarwarin game da tsarin da aka yi amfani da su musamman don ciwon daji ba. Ga wadanda suke amfani da magungunan magungunan likita don tsadar cholesterol a lokacin da ake jijiyar cutar ciwon huhu, waɗannan nazarin na iya zama tushen karfafawa. Kuna iya so a tattauna halinka na musamman da ya hada da bayanin ku na lipid tare da likitan likitan ku kuma tambaye ta abin da ta ke tunani game da wannan bayani.
Wannan bayanin kuma ya zo a lokacin da ake kira tambayoyin da suka gabata game da cholesterol. A watan Disamba na shekara ta 2014, wani takardun littafi na kwamitin Shawarar Shawarwari na Dietary Guidelines ya bayyana cewa ba za'a sake daukar nauyin cholesterol mai cin abinci ba a matsayin mai gina jiki akan damuwa. Wannan shine ainihin batun da za a buƙaci a tattauna da kuma rarraba tsakanin ku da likitanku.
Matakai na gaba
Akwai wasu abubuwa masu sauƙi waɗanda mutane zasu iya yin kansu don inganta rayuwa tare da ciwon huhu na huhu. Bincika waɗannan abubuwa 10 wadanda zasu inganta rayuwarku daga cutar ciwon huhu .
Sources
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