Idan kuna yin wani littafi game da cutar cututtukan zuciya kwanan nan, ko kuma idan kun yi magana da likitanku a kwanan nan game da hana ko magance cututtukan zuciya, mai yiwuwa kuka sami maganganun "rashin jin dadi na karshe." Halin yanayin rashin jin dadi na karshe ya zama da muhimmanci a cikin shekarun nan zuwa fahimtar yawancin cututtuka na zuciya, ciki har da cututtukan cututtuka (CAD) , hauhawar jini , angina microvascular ( ciwon zuciya na zuciya x ), dysfunction diastolic , da sauransu.
Dysfunction endothelial wani yanayin ne wanda ƙarshen din din din din (cikin rufin ciki) na kananan kararrawa ya kasa aiki akai-akai. A sakamakon haka, yawancin abubuwa masu kyau zasu iya faruwa da kyallen takalma wanda wa] anda ke ba su.
Yanayi na Endothelial Layer
A cikin jigilar jiki (ƙananan ƙararrakin da ke tsara ruwan jini zuwa kyallen takalma), endothelium shine rufin ciki na sel wanda yana da ayyuka masu mahimmanci.
Endothelium yana kula da dulluwa da ƙuntatawa na jini. Wannan aikin ya ƙayyade a cikin lokaci-lokaci-lokaci nawa ne yawan jini ya karu da nau'ikan takalmin jiki. Endothelial "sautin" ma yana ƙayyade ƙin jini, da kuma nauyin aiki da zuciya dole yayi don zub da jini daga jiki.
Har ila yau endothelium yana kare kyallen takarda daga abubuwa masu guba masu guba; yana sarrafa jini clotting mechanism; ya sarrafa ruwa, masu zazzagewa, da sauran abubuwa masu yawa da ke tafiya tsakanin jini da kyallen takalma; da kuma gyaran kumburi cikin kyallen takarda.
Abin da wannan yake nufi shi ne cewa aiki mai kyau na endothelium yana da mahimmanci ga aikin al'ada da ƙwayoyin jiki.
Lokacin da daman aiki na karshe ya kasance, ƙwarewar yin aiki ɗaya ko fiye daga cikin waɗannan ayyuka masu muhimmanci ana daidaitawa.
Dalili na Dysfunction
Saboda endothelium yana da mahimmanci ga ayyuka masu yawa, da yawa ana gudanar da bincike don fahimtar duk abin da ke haifar da dasfunni na endothelial.
A wannan lokaci yana da alamun rashin cin zarafi na endothelial yana da alaka da raguwa a cikin matakan nitric oxide (NO) a cikin ganuwar jini.
NO ne gas wanda aka samo ta hanyar metabolism na amino acid (L-arginine). NO, wanda yake da ɗan gajeren rabi, yana aiki a gida a cikin jini don taimakawa wajen canza sautin jini da kuma sauran muhimman ayyukan da ke da iyaka. Rashin rashi a cikin NO wanda ya haifar da rikicewar jini (wanda zai iya haifar da hawan jini), yana taimakawa wajen kunna platelets (wanda ke haifar da jini), yana ƙaruwa da kumburi a cikin ganuwar jini, kuma yana ƙaruwa da kullun ganuwar jirgin ruwa don lalata lipoproteins da magunguna daban-daban.
Don taƙaitawa, lalacewar endothelial yana nuna rashin rage yawan ciwon daji ba tare da matakan ba, wanda, daga bisani, ke haifar da ƙwayoyin cuta masu yawa a aikin jirgi na jini. Wadannan abubuwan haɗari suna aiki da inganta atherosclerosis . Bugu da ƙari, ƙyamawar endothelial zai iya haifar da ƙananan ƙwayoyin ƙararraji, kuma an yi la'akari da cewa babbar hanyar haifar da ciwo na zuciya x da yiwuwar, rashin ciwon diastolic.
Abokan Hulɗa da Halayen Jakadancin
Hanyar hanyoyin da mutum ke tayar da dysfunction endothelial har yanzu ana aiki.
Duk da haka, yana bayyana a fili cewa yawancin matsalolin likita, halaye, da abubuwan da ba za a iya yiwuwa ba zasu iya taimakawa gare shi, ciki har da:
- Hawan jini
- Ciwon sukari
- LDL cholesterol da matakan triglyceride
- Shan taba
- Sedentary salon
- Jigilar motsin rai ( Cutar cardiomyopathy, wanda aka fi sani da "ciwon zuciya na zuciya ", yanzu an yi zaton zai haifar da mummunar cututtuka na rashin jin dadi.)
- Cutar
- Zuciyar zuciya
- Hypothyroidism
- Osteoporosis
- Matar
- Chemotherapy da radiation far
- Harkokin halitta
Sanin asali
Samar da ganewar asali na dysfunction endothelial yawanci ba dole ba. Wani mataki na dysfunction endothelial za a iya amincewa da shi a duk wanda ke da CAD, hauhawar jini, ko kuma babban haɗari ga cututtukan zuciya (musamman waɗanda aka ambata a sama).
Saboda haka, ainihin ƙaddamar da aikin endothelial mai haƙuri ba wani abu ne da likitoci suke yi ba. Amma idan ana tsammanin dysfunction endothelial a cikin mutum ba tare da dalilai masu ban mamaki ba (kamar mutum yana tunanin ciwon ciwon zuciya na x), za a iya tabbatar da ganewar asali da gwaje-gwajen da za su iya auna ƙimar jini don kwantar da hankali da / ko ƙuntatawa a amsa ga gwamnatin miyagun ƙwayoyi.
Jiyya
Ayyukan Endothelial zai iya inganta ta hanyar tsarin salon rayuwa wanda ake buƙatawa akan mu duka don rage ƙwayar cutar cututtuka, ciki har da asarar nauyi, motsa jiki, shan taba, karfin hauhawar jini, da kuma kula da ciwon sukari.
Wasu daga cikin wadannan matakan tsaro sunyi rubuce-rubuce don rage rashin lalacewa na ƙarshen gida. Wadannan sun haɗa da:
- Yin amfani da magunguna na statin
- Aspirin
- Abincin noma
- Sauran matakan da suka hada da kwayoyi, man zaitun, cakulan cakulan, koren shayi, abincin da aka shuka.
- Ayyukan motsa jiki
- Asarar nauyi
Bugu da ƙari, ana amfani da magunguna da yawa don ganin ko za su iya inganta dysfunction na endothelial a cikin hanya mai mahimmanci. Wasu daga cikin wakilan da suka nuna alamun sun hada da nifedipine , wasu masu hana ACE , estrogen, ranolazine , da sildenafil .
Kalma Daga
A cikin 'yan shekarun nan masu bincike na likita sun gano cewa rashin ciwon gurguntacciyar ƙasa kamar muhimmiyar mahimmanci ne ga matsaloli na zuciya na zuciya. Duk da yake ana gudanar da bincike na aiki don gano hanyoyin da za a inganta aikin endothelial, saboda haka rage hadarin cututtukan zuciya, akwai riga da yawa da za mu iya yi game da shi. Musamman ma, ya kamata mu tabbatar da samun cike da motsa jiki, dakatar da shan taba, kuma tabbatar muna aiki tare da likitocinmu don sarrafa hawan jini ko ciwon sukari, idan muna da waɗannan yanayi.
> Sources:
> Crea F, Camici PG, Bairey Merz CN. Ƙunƙashin ƙwayoyin cuta na zuciya-da-gidanka: An sabuntawa. Eur Heart J 2014; 35: 1101.
> Greenland P, Alpert JS, Beller GA, et al. 2010 ACCF / Dokar Sharuɗɗa ta AHA don Gudanar da Ƙwayar Tsarin Kwayoyin Lafiya a cikin Asymptomatic Adults: Rahoton Cibiyar Kasuwanci na Ƙungiyar Harkokin Kwafa ta Ƙasar Amirka da Ƙungiyar Ayyuka ta Ƙungiyar Amirka game da Sharuɗɗan Ɗaukaka. J Am Coll Cardiol 2010; 56: e50.