Sashe na 2 na 3
Kamar yadda muka koya a wani ɓangare, Mene ne Bayanin Ƙarshe na Ƙarshe, mutanen da ke fama da ciwo mai tsanani ( ME / CFS ) sun ga wani abu mai ban mamaki da ke nuna alamun bayyanar bayan aiki. Wannan wata alama ce ta cututtukan cutar da kuma abin da masu bincike suka yi ƙoƙari su gano shekaru. Har yanzu muna da abubuwa da yawa don koyo game da wannan alamar, amma mun sani cewa ananan nau'o'in maganin ilimin lissafi suna danganta da malaise mai matsayi (PEM).
Abubuwa da suka shafi jiki
Masu bincike sun gano nau'o'in halayen motsa jiki a cikin tsarin da yawa, ciki har da tsarin rigakafi, tsarin kulawa na tsakiya, da tsarin kwakwalwa. Ya zuwa yanzu, duk da haka, sun kasa gane cewa wadannan abubuwan haɗari shine dalilin (P) na PEM. Binciken da aka yi a shekara ta 2014 game da wallafe-wallafe na likita sun gano dabarun da aka yi a cikin ME / CFS, da dama waɗanda aka haɗa su da motsa jiki da kuma PEM. Wadannan sun hada da:
- Amsar da aka fi sani a cikin tsarin haɗin gwiwa (wani ɓangare na tsarin da ke taimakawa wajen kawar da pathogens daga jiki),
- Haɓakawa a cikin danniya mai ƙyama (wani nau'i na lalata salon salula) hade tare da amsawar antioxidant mara kyau,
- Canje-canje a cikin bayanan maganganun jigilar kwayoyin halitta.
Sauran binciken (Morris 2014) yayi nazarin abubuwan da ke haɗuwa da wani abu da ake kira adenosine triphosphate (ATP), wanda shine nau'i na makamashi. ME / CFS an yi imanin cewa an hade shi da ikon da zai iya ƙirƙirar ATP a matakin mitochondrial.
(Mitochondria su ne sifofi a jikinka wanda ke juyo kayan abinci a cikin ATP.)
Binciken da aka yi a 2015 ya yi amfani da samfurin kwamfuta na cutar (Lengert) yayi la'akari da ƙananan matakan ATP, wanda yawanci zai haifar da ƙananan yawan mutuwar cell. Sarkar jigon farawa tare da low ATP ya haifar da rikice-rikice na immunological da damuwa na oxyidative, bisa ga samfurin.
Masu bincike sun ce irin wannan cigaba ya sa yanayin ya zama mafi muni. A shekara ta 2012, takarda da ke nazarin aikin mitochondrial da ME / CFS (Morris) sun tattauna abubuwa masu yawa, ciki har da:
- Hanyoyi na immuno-inflammatory aiki,
- Ƙara yawan matakan pro-inflammatory cytokines ,
- Ƙarin matakan nukiliya factor-kB,
- Ayyuka a ayyuka na mitochondrial, ciki har da low production of ATP.
Masu binciken sunyi bayanin cewa wadannan dalilai na iya, a kalla a cikin wani ɓangare, na haifar da ƙarancin mitochondrial, wanda ke nufin cewa lokacin da jiki ya bukaci makamashi (a matsayin ATP), makamashi ba a can ba.
Wani binciken na 2015 ya yi amfani da irin nau'in da ake kira da ake kira bidiyon infrared spectroscopy don yin amfani da iskar oxygen lokacin aikin motsa jiki. Idan aka kwatanta da masu lafiya a cikin rukunin kulawa, an samu masu halartar ME / CFS da canje-canje marar haɓaka a oxygenation na hemoglobin (wani sinadarin dake cikin kwayoyin jini mai launin jini wanda ke dauke da oxygen zuwa sel dinku) bayan an yi aiki.
Duk wani haɗuwa da waɗannan abubuwan zai iya taimakawa wajen yin amfani da PEM. Duk da haka, masu bincike suna da aiki mai yawa a gabansu. Wasu masu bincike sun nuna cewa za'a iya amfani da wasu ƙananan abubuwa a matsayin alamaccen alamar ganewa ga ME / CFS yayin da wasu sun yarda cewa PEM na iya zama hanya mai amfani ga likitoci su auna ƙananan rashin lafiya.
Mafi mahimmanci, yawancin zamu koyi game da abin da ke faruwa a cikin jiki a lokacin PEM, mafi kusantar mu fahimci yadda za'a bi da shi.
Ƙara Ƙarin
Sources:
Lengert N, Drossel B. Kimiyyar ilmin halitta. 2015 Jul; 202: 21-31. A cikin silico bincike na rashin haƙuri rashin haƙuri a cikin myalgic encephalomyelitis / na kullum gajiya ciwo.
Miller RR, et al. Journal of medicine translational. 2015 Mayu 20; 13: 159. Gwajin gwaji ta kusa da jigilar cututtuka mai ƙananan infrared in myhagic encephalomyelitis / ciwo mai tsanani ga marasa lafiya marasa lafiya idan aka kwatanta da kyawawan lafiya: binciken da aka gudanar da shari'a.
Morris G, Maes M. Magunguna. 2012 Nov; 79 (5): 607-13. Ƙarin makamashin nukiliya factor-kB da asarar p53 sune mahimman hanyoyin da ke cikin ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar cuta / ciwo mai tsanani (ME / CFS).
Morris G, Maes M. Metabolic cutar kwakwalwa. 2014 Mar, 29 (1): 19-36. Mitochondrial dysfunctions a cikin myalgic encephalomyelitis / ciwon daji ciwo ciwo bayyana ta hanyar immuno-inflammatory, hanyoyin oxidative da nitrosative hanyoyi.
Nijs J, Nees A, et al. Bincike na maganin rigakafi. 2014; 20: 94-116. Sauya ba shi da amsa ga motsa jiki a cikin marasa lafiya da ciwo mai wuya kullum / myceptive encephalomyelitis: nazarin wallafe-wallafe na al'ada.