Haɗuwa da kwayar cutar kwayar cutar HIV a cikin mafi yawan waɗanda aka rubuta a duniya
Ƙayyadewa
Atripla shine kwaya guda daya, kwayar maganin maganin maganin ƙwayar cuta (FDC) wadda take kunshe da wakilai guda uku: antinfovir, emtricitabine da efavirenz.
Tenofovir da emtricitabine duka sunaye ne a matsayin ƙananan magungunan kwakwalwa na tsakiya kuma an sayar da kansu kamar yadda Viread (tenofovir) , Emtriva (emtricitabine, FTC), da kuma FDC Truvada (tenovfovir + emtricitabine).
Efavirenz ya bambanta, wanda ba shi da magungunan ƙwaƙwalwar ƙwaƙwalwar sassauki kuma yana kasuwanci ne a matsayin kasuwanci kamar Sustiva (efavirenz) .
Aikin Jirgin abinci da Drug Administration na Amurka (FDA) a Atripla ya ba da izini a ranar 12 ga Yuni, 2012 kuma shine karo na farko na yau da kullum, magani guda uku da aka yarda don amfani a maganin HIV ga tsofaffi da yara masu shekaru 12 da haihuwa.
Har zuwa shekara ta 2015, Atripla ya zama matsayi mafi kyau, na farko na maganin cutar kanjamau a Amurka, tare da kusan kashi ɗaya bisa uku na dukkan marasa lafiya da aka umurce su. Sabbin magunguna na gaba (waɗanda suka kasance masu raguwa da yawa kuma sun fi dacewa) sun ƙare Atripla daga jerin "miyagun ƙwayoyi" a matsayin matsayin "madadin" na farko.
A halin yanzu babu wani tsari na generic na Atripla a Amurka
Atripla Formulation
Atripla wani shafi ne wanda aka tsara tare da shi wanda ya hada da 300mg tenofovir disoproxil fumarate, 200mg emtricitabine, da 600mg na efavirenz.
Ruwan ruwan hoda, oblong kwamfutar hannu ne mai hotunan fim kuma an saka shi a gefe daya tare da lamba "123."
Atripla Dosage
Ga tsofaffi da yara masu shekaru 12 ko tsufa wadanda suke auna akalla 87 lbs (40kg): daya daga cikin kwamfutar da aka yi amfani da shi a cikin komai a ciki, da ma a lokacin kwanta barci (saboda damuwa da zai iya fitowa sakamakon sakamako na efavirenz).
Ga marasa lafiya shan rifampin (ana amfani dasu akai-akai a cikin maganin tarin fuka-fuka) wanda yayi nauyi a kalla 110 lbs (50kg): daya daga kwamfutar kwamfutar Atripla da ɗayan littafan Sustiva (efavirenz) sunyi magana a hankali, kuma a cikin komai a ciki da kuma dacewa a lokacin kwanta barci.
Ayyukan Asripla
Abubuwa masu rinjaye na yau da kullum da suka haɗa da Atripla amfani (faruwa a akalla 5% na lokuta) sun hada da:
- Jiɗa
- Diarrhea
- Wulo
- Sinusitis
- Ciwon kai
- Dizziness
- Dama
- Insomnia
- Abubuwa masu ban sha'awa
- Rash
Yawancin cututtuka sun kasance masu tsayayya, sau da yawa suna warware kansu cikin mako guda ko biyu. Wasu daga cikin mummunan tsarin tsarin jiki, kamar damuwa, wani lokaci yana da tsayi don warwarewa, kodayake shan kwayoyin kwayoyi a daren, kafin kwanta barci, yayi kokarin rage alamun bayyanar.
Contraindications
- Antifungal magani: Saurin (voriconazole)
- Hepatitis B magani: Hepsera (adefovir)
- Abubuwan da aka gano Ergot (ciki har da Wigraine da Cafergot)
- Calcium tashar blockers: Vascor (litripil), Propulsid (cisapride), Orap (pimozide)
- St. John's Wort
Ra'ayin Nazarin
Marasa lafiya waɗanda suka rigaya suka sha wahala, sun kasance da halayen da suka dace a kan Sustiva (ciki har da mai tsanani ko raguwa) kada a ba da umurni Atripla.
Dole ne a yi amfani da Atripla tare da kula da marasa lafiya tare da tarihin kididdigar koda (koda).
Yi la'akari akai-akai game da ƙwayar halittar mahaifa kafin farawa magani. A cikin marasa lafiya tare da hadarin ƙwayar cutar rash, sun haɗa da ƙaddarar kirkirar mahaifa, magani na phosphorus, furotin glucose da furotin furotin lokacin saka idanu. Dole ne a yi amfani da Atripla a marasa lafiya tare da kimantawar ƙwayar creatinine a kasa 50mL / minti.
Kula da gwajin hanta a marasa lafiya marasa lafiya tare da ciwon hanta, ciki har da hepatitis B da hepatitis C. Ba a ba da shawarar Atripla a cikin marasa lafiya da rashin ciwon hanta ba. Yi amfani da hankali tare da marasa lafiya tare da rashin hasara mai hanta.
Halin da aka yi a Atripla an hade shi tare da haukacin mahaifa a yawancin nazarin dabba.
Yayinda har yanzu akwai gardama game da ko efavirenz yana da haɗari ga ɗan adam, an bada shawara cewa Aripla za a kauce masa a lokacin daukar ciki ), musamman a farkon farkon watanni. Ana kuma shawarci mahaifiyata kada suyi nono yayin shan Atripla.
Dole a yi wa Atripla izini tare da taka tsantsan a cikin mutanen da ke da magungunan, da wadanda suke tare da schizophrenia, ciwon zuciya, ko wasu ƙwayar cuta. An san nauyin sakonnin da zai iya haifar da mummunan tsari, wanda ya haifar da rashin hankali, mafarkai masu kyau, rashin tausayi, da kuma rashin jin daɗi a wasu mutane.
Sources:
Cibiyar Abinci da Druggun Amurka (FDA). "FDA ta yarda da farko da rana daya, Hadin maganin Drug guda uku don maganin HIV-1." Silver Spring, Maryland; sanarwa da aka bayar ranar 2 ga Agusta, 2004.
Bristol Myers Squibb. " Karin Bayani na Bayanin Bayyanawa - ATRIPLA ." 2006.