Masu bincike sunyi kokarin "kaddamar" HIV daga cikin wuraren da yake shafewa
Tankuna na Latent sune kwayoyin jiki inda HIV ke iya ɓoye (ko "nacewa") ko da a fuskar fuskantar farfadowa mafi kyau. Wadannan tafkiyoyin salula suna samuwa a cikin dukkanin tsarin kwayoyin halitta, ciki har da kwakwalwa, nama na lymphoid, kasusuwan kasusuwa da gabar jiki.
A cikin yanayin latent (ko "proviral" ), HIV na iya haɗuwa da kwayoyin halitta a cikin DNA na tantanin tantanin halitta, amma maimakon kashe shi, kawai yayi maimaita tare da mai watsa shiri.
Ba kamar kamuwa da kwayar cutar ba, wadanda ba a iya gano su ba. Maimakon haka ana ɗauke da kwayar cutar ta kwayar cutar daga tsara zuwa tsara, yana iya sake sakewa lokacin da rushewa ya yi aiki a cikin aikin rigakafi.
Yana da, a gaskiya, amsawar rigakafi na jikin da ke samar da kwayar cutar ta HIV. Lokacin da aka kunna amsawar rigakafi a gaban kwayar cutar HIV, jiki zai samar da kwayoyin T-CD4 wadanda, a hankali, shine ainihin manufa ga kamuwa da cuta. Sel da suka kamu da kwayar cutar HIV za su kara girma, samar da ƙarin kwayar cutar kwayar cutar HIV da kuma fadada tafkin jini.
Yana da ci gaba da waɗannan ƙwayoyin cuta masu ɓoye waɗanda ke ci gaba da ƙuntata ƙoƙari don inganta maganin cutar.
Manufofin don share wuraren dakunan Latent
Babban kalubalen da masana ke fuskanta a yau shine gano hanyoyin da za su kunna da kuma kawar da kwayar cutar HIV daga tafkiyoyin layi, ta bar shi a fallasa kowane nau'i na magunguna .
Yayin da ART ta iya kammala waɗannan tafki a tsawon lokaci, yana da sosai sannu a hankali. Hanyoyin ilmin lissafi sun nuna cewa zai dauki tsakanin 60 zuwa 80 da shekaru don kawar da cikakken magancewa.
Bugu da ƙari, masu bincike suna kallon yin amfani da wasu kwayoyi da suka nuna cewa zasu taimaka wajen maganin cutar HIV.
Daga cikin su akwai wakilan da ake kira HDAC masu zanga-zanga, wanda aka dade suna amfani da su a matsayin masu tayar da hankali da kuma maganin marasa lafiya.
Kuma yayin da akwai nasarar samun cigaban cutar HIV, masana kimiyya ba su da tabbacin yadda waɗannan tafkiyoyin suke da yawa ko kuma wasu kwayoyin halitta na iya samar da HIV a ɓoye. Saboda haka, bashi yiwuwa a san ko wadannan magunguna sun wanke wannan tafki.
Binciken da aka yi kwanan nan, a gaskiya, ya nuna cewa yayin da wasu magungunan magungunan HDAC suna da damar yin aiki da cutar HIV, babu wata hujja ta ainihi cewa irin wannan izinin ya rage girman maɓuɓɓuka.
Sauran masana kimiyya, a halin yanzu, suna tambaya ko "kicking" HIV daga tafkiyoyinsa zai isa ya cimma nasarar kawar da su. A sakamakon haka, yawancin kamfanonin bincike suna binciken mahalli wanda ya nuna cewa zai iya kashe cutar ta sabuwar ƙwayar cuta tare da kadan mai guba. Daga cikin 'yan takarar mafi yawan masu alfaharin shi ne acitretin, wani nau'i na bitamin A a halin yanzu ana amfani da shi wajen magance psoriasis mai tsanani a cikin manya.
Sakamakon Imamanci na Latent
Ɗaya daga cikin abubuwan da ke damuwa da maganin cututtuka na kwayar cutar ita ce, ko da a cikin jihar ta gaba, bayyanar cutar HIV a cikin kwayoyin halitta tana haifar da amsa mai zafi. Ko da mutum yana da tasirin cutar HIV kuma yana iya kula da kariya ta kwayar cutar , wannan mummunan ciwon ƙwayar cuta zai iya cigaba da tasiri a hanyar da kwayoyin halitta da kyallen takalma suke yi, yadda ya gaggauta saurin tsarin tsufa.
Shirin, wanda ake kira tsohuwar kwayar cutar , shine dalilin da yasa mutane da ke dauke da kwayar cutar kanjamau sun kamu da cutar, cututtukan zuciya, ƙananan ƙwayar cuta, da nakasar neurocognitive-kuma sau da yawa shekaru 10 zuwa 15 kafin abin da ake bukata a cikin general yawan jama'a.
Sources:
Douek, D. " Saukewa da gaggawa , Cutar HIV, da Cure." Sassan cikin maganin Antibiral. Maris 2013; ya shiga ranar 19 ga Nuwamba, 2015.
Sáez-Cirión, A .; Bacchus, C. Hocqueloux, L ;; et al. "Masu kula da maganin HIV-1 da maganin cutar HIV-1 tare da Tsare-tsaren Tsarin Tsaro na Tsayawa Da Tsayawa Bayan Tsayawa Bayan Kashewar Saurin Ƙaddamar Da Ciwon Nazarin Harkokin Cutar Kwayoyin Kwayoyin cuta na ANRS VISCONTI." PLoS Pathology. Maris 14, 2013; 0 (3): e1003211.
Søgaard, O .; Graverson, M .; Leth, S .; et al. "The inhibitor HDAC romidepsin ne mai lafiya da kuma yadda ya kamata ya juya HIV-1 latency a vivo kamar yadda aka auna ta hanyar misali na asibiti." Taro na 20 na Cibiyar Sida ta Duniya; Yuli 22, 2014; Melbourne, Australia; m TUAA0106LB.
Eisele, E. da Siciliano, R. "Rashin tsabtace tafkin da ke dauke da cutar ta HIV da 1." Immunity. Satumba 21, 2012; 37 (3): 377-388.
Peilin, L .; Kaiser, P .; Lampris, H .; et al. "Yada hanzarin hanyar RIG-1 don kashe kwayoyin a cikin tafkuna masu tasowa bayan yin amfani da bidiyo." Yanayin Magunguna. Yuni 13, 2016; 22: 807-8-11.