Arthritis da Fibromyalgia Marasa lafiya Za a Yi Bayanin Abubuwa
Kuna iya mamakin idan likitanku ya bada shawarar maganin antidepressant na ciwo na kullum. Shin wannan saboda ta yi imanin cewa kayi takaici? Ko kuma antiopressants zasu iya taimakawa tare da ciwo har ma ga mutanen da ba tare da wani alamu na ciki ba? Bari mu dubi abin da binciken ya koya mana game da muhimmancin nau'o'in maganin antidepressants a maganin ciwo mai tsanani.
Jirgin tsakanin Tsakanin ciki da Raunin Biki
Ba al'ada ba ne ga mutanen da ke fama da cututtukan cututtuka na yau da kullum, irin su arthritis na rheumatoid , lupus , fibromyalgia , da kuma ciwon neuropathic da ke sha wahala . Mutane da ke fama da matsaloli na jiki suna da yawan ciwon rayuwa mai tsanani. A wasu kalmomi, ciwo da damuwa sukan kasancewa a cikin mahaukaci (tafi hannu a hannu.) A gefe guda na jinsi, yawancin mutanen da aka bincikar da ciwon ciki kuma suna fama da ciwo na kullum. Hanya tsakanin damuwa da ciwo na kullum yana aiki a duka wurare.
Wannan ya ce, ba al'ada ba ne ga mutanen da ke fama da matsanancin ciwo da za a ba su takaddun shaida ko da ba su da wata alamar cututtuka.
Antidepressants na Bikin Bala'i Ba tare da Co-Cikin Ganawa
Duk da yake an riga an umurce antidepressants don bunkasa yanayin marasa lafiyar marasa lafiya a cikin kwakwalwa ta hanyar amfani da ƙananan kwakwalwa a cikin kwakwalwa, ana iya sanya takardun maganin rigakafi a matsayin magani na farko don ciwo mai tsanani, rashin damuwa, ko rashin barci.
Idan aka yi amfani da su don ciwo na kullum da manufar su shine mafi yawan lokuta kamar " adjuvant analgesics ." Wannan yana nufin cewa an tsara su tare da wasu magunguna masu shan magani maimakon amfani da su kawai a matsayin maganin ciwo. (Ƙara koyo game da magunguna guda biyar da ake amfani dasu don magance ciwo na kullum .)
Hanyar da ta dace da magungunan antidepressants da ke aiki don magance ciwo shine wanda ba a sani ba, ko da yake yana nuna cewa hanyar da suke taimakawa na ciwo mai tsanani ba zai iya kasancewa da alaka da hanyoyin da suke haifar da baƙin ciki ba.
An yi tunanin cewa antidepressants na da tasiri a kan serotonin neurotransmitters da norepinephrine , musamman tare da sauko hanyoyin ƙananan ciwon ƙwayoyi. Hakanan magunguna na iya aiki ta hanyar masu karɓa na histamine ko tashoshin sodium.
Ƙungiyoyin Antidepressants
Akwai hanyoyi daban-daban na antidepressants da aka gwada ga mutanen da ke fama da ciwo na kullum da kuma hanyar da guda ɗaya na aiki na antidepressant zai iya bambanta da wani. Drugs wanda aka binciken sun hada da:
- Tidicclic anticpressants
- Maɗaukaki masu sukar maganin serotonin (SSRIs)
- Serotonin da norepinephrine reuptake inhibitors (SNRIs)
- Norepinephrine da dopamine reuptake inhibitors (NDRIs)
- Masu haɗin gwaninta da haɓaka masu karɓa
- Monoamine oxidase inhibitors (MAO masu hanawa)
Bari mu dubi kowane ɗayan ɗayan nan daban.
Tricyclic Antidepressants
An yi amfani da antidoppress na Tricyclic azabar maganin ƙuntatawa kafin a ci gaba da SSRIs. Duk da yake an yi amfani da wadannan kwayoyi fiye da sau da yawa don rashin ciki, su ne mafi yawan magungunan antidepressant da ake amfani dasu don ciwo na kullum. Sun bayyana cewa sun fi tasiri a cikin kula da ciwon cutar neuropathic amma an yi amfani dashi a kan kowane irin ciwo.
Magungunan ƙwayoyin da ake kira su masu amfani da maganin tricyclic sun hada da:
- Elavil (amitriptyline)
- Ascendin (amoxapine)
- Anafranil (clomipramine)
- Pamelor (nortriptyline)
- Norpramin (desipramine)
- Tofranil (imipramine)
- Vivactil (protriptyline)
- Surmontil (trimipramine)
- Sinequan (doxepin)
Idan ana amfani da magungunan antitprints (musamman amitriptyline) don ciwo na kullum, an ba su a cikin asurai da yawa fiye da waɗanda aka yi amfani da ciki, saboda haka yawanci suna haifar da ƙananan sakamako. Hanyoyin kullun na yau da kullum zasu iya haɗawa da hangen nesa, riba mai nauyi, da barci.
Ma'aikata Masu Saukewa na Serotonin Reuptake (SSRIs)
Masu sukar maganin serotonin (SSRIs) sune wasu daga cikin magungunan antitaptocin da aka ba su kyauta don rashin tausayi da damuwa.
Drugs a cikin wannan rukuni sun haɗa da:
- Prozac (fluoxetine)
- Lexapro (escitalopram)
- Luvox (fluvoxamine)
- Hanyar (Citalopram)
- Zoloft (sertraline)
- Paxil (paroxetine)
Kamar yadda sunan ya nuna, SSRI yayi amfani da kwayoyin neurotransmitter (kwakwalwa na kwakwalwa) na serotonin kuma burin shine kara yawan matakan serotonin a kwakwalwa. SSRIs suna da magungunan maganin magungunan marasa lafiya da yawa kuma yawancin sakamako na yawanci kuma sun fi dacewa fiye da wadanda ke hade da magungunan antitpress.
Nazarin duba yadda ake amfani da SSRIs don ciwo mai tsanani ba tare da ciwon zuciya ya gano cewa wadannan kwayoyi sunyi tasiri a kan mafi yawan yanayi na ciwo ba, amma ana buƙatar ci gaba da bincike.
Serotonin da Norepinephrine Reuptake Inhibitors (SNRIs)
Serotonin da masu nasupinephrine reuptake (SNRIs) sun zartar da serotonin neurotransmitters guda biyu da norepinephrine kuma ana daukar su dual inhibitors saboda wannan dalili.
Dukansu SSRIs da SNRIs na iya taimakawa wajen magance ciwo da kuma gajiya da suka shafi yanayin ciwo ko fibromyalgia, amma SNRIs na iya zama mafi tasiri fiye da SSRIs dangane da taimakon jin zafi.
Drugs a cikin wannan rukuni sun haɗa da:
- Cymbalta (Duloxetine)
- Mafarki (venlafaxine)
- Pristiq (desvenlafaxine)
- Savella (milnacipran)
Cydalta ya amince da shi don maganin fibromyalgia a shekara ta 2008 da kuma maganin ciwo na musculoskeletal a shekarar 2010.
Abubuwan da ke tattare da kwayoyin cutar tare da SNRIs sun hada da tashin hankali, hasara na ci, damuwa, ciwon kai, rashin barci, da gajiya.
Norepinephrine da Dopamine Reuptake Inhibitors (NDRIs)
NDIRs wani nau'in antidepressant, tare da bupropion (Wellbutrin ko Zyban) babban magunguna a cikin wannan aji.
Abubuwa masu lahani na al'ada sun hada da tashin hankali, tashin zuciya, ciwon kai, hasara na ci, rashin barci, da ƙara yawan karfin jini.
Maƙallan Maƙallan Reuptake da Masu Tsara Maɗaukaki
Haɗin haɗin haɗuwa Masu amfani da masu ƙwaƙwalwar ajiya da masu karɓar mai karɓa zasu iya amfani da su don rashin ciki, yanayin barci, ko lalacewar lalacewa ta kullum kuma sun haɗa da:
- Desyrel ( trazodone )
- Remeron (mirtazapine)
- Sake Sautin (nefazodone)
Abubuwa masu yawa sun haɗa da laushi, bushe baki, tashin zuciya, da rashin hankali, kuma waɗannan kwayoyi bazai amfani da su ba tare da tarihin halayen hanta.
Ma'aikatan Monoamine Oxidase (MAO Masu Shayarwa)
MAO Masu hanawa sune magunguna masu tsufa waɗanda ba a yadu da su don magance matsalolin ko wasu yanayi saboda sakamako mai tasiri.
- Nardil (phenelzine)
- Parnate (tranylcypromine)
- Marplan (isocarboxazid)
- Emsam (zalunci)
Akwai ƙuntatawa da yawa don mutanen da suke amfani da kwayoyi kuma suna da mahimmanci masu tasiri.
Nazarin kan Yin Amfani da Magungunan Antivirus don Raunin Matsala
Binciken bincike sun sami amfana daga amfani da maganin antidepressants a cikin kula da ciwo mai tsanani a cikin manya, musamman amitriptyline. Abin takaici, akwai bayanai kadan game da amfani da maganin antidepressants na rashin ciwo da ke fama da ciwon daji a yara ko matasa.
Magunguna sun amince da yin amfani da Label na Kayan Ciniki da vs Kashe-Kashe
Lokacin da yake magana game da amfani da antidepressants na ciwo na kullum yana da mahimmanci don rarrabe kwayoyi da aka yarda don wannan amfani da wadanda aka yi amfani da su-lakabin. Lokacin da miyagun ƙwayoyi ne FDA da aka yarda don amfani da shi na nufin FDA ta sake nazarin karatun kuma ya gano cewa miyagun ƙwayoyi na iya zama tasiri da ingancin aminci ga wannan amfani. Amfani da lakabin yin amfani da shi , duk da haka, yana nufin magungunan da FDA ta yarda don yanayin daya (alal misali a nan, baƙin ciki) amma ana iya amfani dasu don wani dalili (alal misali, ciwo na kullum).
Gargaɗi game da Amfani da magunguna
Amfani da antidepressants ba tare da gargadi ba. FDA ta bayyana cewa ya kamata a kula da tsofaffi da kuma yara musamman saboda ƙuntatawa ko ƙin zuciya ko kuma hali a cikin watanni na farko na jiyya ko bin wata canjin magani. Dole ne mutane su tuntubi likita su nan da nan idan matsalolin halayya sunyi rikici ko kuma idan sukarin tunani ko hali ya karu. Har ila yau, yana da mahimmanci ga waɗanda suke daukar maganin antidepressant don su san matsalolin haɗari da alamun gargadi na kashe kansa.
Gaba na Ƙasa akan Amfani da Antidepressants na Balarin Biki
Tsarin shafewa zai iya taimakawa ga mutanen da suke fama da ciwo mai tsanani a hanyoyi fiye da ɗaya. Mutane da yawa da ke zaune tare da fibromyalgia ko wasu lokuta na ciwo na kullum suna sha wahala daga ciki. Duk da haka wasu antidespressants na iya samar da taimako daga ciwo na kullum ta hanyar daban-daban hanyoyin. Daga cikin nau'o'i daban-daban na antidepressants, magungunan antidopic tricyclic, musamman amitriptyline, an kimantawa sosai, musamman don maganin ciwon neuropathic.
Yin fama tare da ciwo na kullum yana da wuya, kuma yana rinjayar kowane ɓangare na rayuwarka. Haɗuwa da magungunan magungunan (kamar ƙara a antidepressant) zai iya zama mafi amfani, amma magungunan marasa magani da gudanarwa na jituwa suna da mahimmanci.
> Sources:
> Chou, R., Devo, R., Friedly, J. et al. Magungunan Pharmacologic System na Ƙananan Raunin Kuskuren: Binciken Tsaro na Kwalejin Kwalejin Kwararrun Kwararrun Kwararrun likitoci. Annals na Internal Medicine . 2017. 166 (7): 480-492.
> Cooper, T., Heathcote, L., Clinch, J. et al. Magungunan rigakafi don rashin lafiyar marasa lafiya a cikin yara da matasa. Cochrane Database of Manyan Labarai . 2017. 8: CD012535.
> Dosenovic, S., Jelicic Kadic, A., Miljanovic, M. et al. Ayyuka don Neuropathic Pain: Wani Bayani na Binciken Tsaro. Anesthesia da Analgesia . 2017. 125 (2): 643-652.
> Patetsos, E., da E. Horjales-Araujo. Yin maganin cutar tare da SSRIs: Menene Muke Sanuwa? . Cibiyar Bincike da Gudanarwa . 2016. 2016: 2020915.