Kwayoyin cututtuka, ganewar asali, da Zabin Lafiya don Lymphoplasmacytic Lymphoma
Menene Macroglobulinemia na Waldenstrom kuma me kake bukatar sanin ko an gano ku da wannan cuta?
Waldenstrom Macroglobulinemia - Ma'anar
Waldenstrom macroglobulinemia (WM) wani nau'i ne na lymphoma ba na Hodgkin (NHL) . WM shine ciwon daji wanda ke shafar ƙwayar lymphocytes na B (ko kuma B) kuma an nuna shi ta hanyar cigaba da sunadaran da ake kira IgM antibodies.
Ana iya kira WM kamar Macroglobulinemia Waldenstrom, macroglobulinmia mai mahimmanci, ko lymphoma lymphoma.
A WM, ƙwayar ciwon daji na ciwon daji yana faruwa a cikin ƙwayoyin lymphocytes B kafin su girma cikin kwayoyin plasma. Kwayoyin Plasma suna da alhakin samar da kwayoyin cutar antibody. Saboda haka, yawan yawan wadannan kwayoyin suna haifar da ƙara yawan adadi na musamman, IgM.
Alamai da cututtuka na WM
WM zai iya shafar jikinka cikin hanyoyi biyu.
Bone marrow crowding. Kwayoyin lymphoma zasu iya tara kasusuwan ka, wanda zai sa wuyarka ta samar da adadi mai yawa na platelets, da jini na jini, da kuma fararen jini . A sakamakon haka, wadannan kasawan zasu haifar da alamu da bayyanar cututtukan da ke da alamun anemia (ƙananan jinin jini), thrombocytopenia (ƙananan ƙidaya platelet), da neutropenia (ƙananan neutrophil count - neutrophils guda daya ne na jini) . Wasu daga cikin wadannan bayyanar cututtuka sun haɗa da:
- Abubuwa da yawa ko zubar da jini, irin su zub da jini, ƙuƙwalwar ƙuƙwalwa, ko hanci
- Sukan ji daɗin gajiya, duk da cewa kuna samun barci sosai
- Rawancin numfashi tare da kowane aiki
- Kwayar cuta ko rashin lafiya wanda ba za ka iya yin yaki ba
- Pale fata
Hyperviscosity . Bugu da ƙari, da tasirinsa a kasusuwan kasusuwa, yawan adadin IgM na cikin jini zai iya haifar da abin da ake kira hypervicity.
A takaice dai, hypervicity yana nufin jini ya zama mai zurfi ko rashin lafiya kuma zai iya samun matsala ta saukowa ta hanyar jinin jinin ku. Hyperviscosity yana haifar da wata alama ta musamman na alamu da bayyanar cututtuka da suka hada da:
- Canje-canje a cikin hangen nesa, irin su blurriness ko damuwa da hangen nesa
- Matsayi canjin yanayi, kamar rikicewa
- Dizziness
- Ciwon kai
- Lamba ko tingling a cikin ƙafa ko hannayensu
Kamar yadda yake tare da sauran lymphoma, kwayoyin cututtuka na iya kasancewa a wasu sassan jiki, musamman ma a cikin hanta da hanta, da kuma haifar da ciwo. Hakanan ƙwayar ƙwayar ɗaɗɗaura na iya kasancewa.
Dole ne ku tuna cewa wadannan alamun da alamun bayyanar na iya zama da dabara kuma zai iya kasancewa a cikin wasu yanayi marasa tsanani. Idan kana damu da kowane canje-canje a lafiyarka, yana da mafi kyau idan ka tuntuɓi likitanka ko likita.
Me ya sa WM?
Kamar yadda yake a cikin sauran nau'o'in ciwon daji, ba a san abin da ke haifar da WM ba. Duk da haka, masu bincike sun gano wasu dalilai da suka fi dacewa da mutane a cikin cutar. Sanannun haɗari sun hada da:
- Shekaru fiye da shekaru 60
- Tarihin wani yanayin da ake kira karamin ƙwayoyin cuta guda ɗaya na muhimmancin da ba a yanke ba (MGUS)
- Tarihin WM a cikin iyalinsu
- Samun ciwon ƙwayar cutar C
Bugu da ƙari, WM yana faruwa a cikin maza sau da yawa fiye da mata, kuma a cikin jama'ar Caucasian yawanci fiye da nahiyar Afirka.
Binciken WM
Kamar yadda yake tare da wasu nau'in jini da ƙwayar wuka, WM yawanci ana bincikar cutar ta hanyar yin amfani da jini da gwagwarmaya da kasusuwan kasusuwan kasusuwan .
Cikakken jini yana iya nuna ƙimar yawan lambobin jinin lafiya mai kyau, kamar jini jini, platelets, da jini mai tsabta. Bugu da kari, gwaje-gwaje na jini zai nuna yawan karuwar IgM protein.
Kwayoyin halitta mai laushi da kuma safarar za su bada cikakken bayani game da nau'in kwayoyin halitta a cikin launi, kuma taimaka likita ya bambanta WM daga wasu nau'in lymphoma.
Yaya aka bi WM?
WM wani nau'in ciwon daji ne wanda ba a sani ba, kuma masu bincike har yanzu suna da hanyar da za su iya koya game da hanyoyin da za a iya samu, da kuma yadda suke kwatanta da juna dangane da tasirin su. A sakamakon haka, mutanen da aka saba samu tare da WM zasu iya zabar shiga cikin gwaji na asibiti don taimakawa masana kimiyya su fahimci wannan yanayin.
Babu magani da aka sani don WM a wannan lokaci, amma akwai wasu zaɓuɓɓukan da suka nuna wasu nasara cikin sarrafa wannan cutar.
- Plasmapheresis: IgM mai girma a cikin jini yana iya haifar da hypervicity ko kauri daga jini. Wannan jini mai tsanani zai iya zama da wuya ga abubuwan gina jiki da oxygen da za a ba da su ga dukkan jikin jikin. Cire wasu daga cikin IgM daga jinin zai iya taimakawa wajen rage karfin jini. A lokacin plasmapheresis , jinin mai haƙuri yana sassaukawa a hankali ta hanyar injin da ke cire IgM sannan ya koma cikin jikin su.
- Chemotherapy da Biotherapy: Marasa lafiya tare da WM ana kula da su da chemotherapy. Akwai hanyoyi daban-daban na kwayoyi wanda za'a iya amfani dashi. Wasu daga cikinsu sun hada da hada Cytoxan (cyclophosphamide) da Rituxan (rituximab) da dexamethasone, ko Velcade (bortezomib) da Rituxan da dexamethasone. Akwai wasu magunguna da hade da kwayoyi da ake amfani da su don magance WM duka a aikace kuma a gwaji na asibiti.
- Yada Cell Transplant: Ba'a sani ba abin da rawar da ya sa cell dashi zai yi wasa a zalunta WM. Abin baƙin ciki shine yawancin marasa lafiyar marasa lafiya na WM na iya rage amfani da cututtukan allogeneic, wanda zai iya haifar da cututtuka masu guba, amma maye gurbin autologous bayan ƙwaƙwalwar cututtukan chemotherapy na iya zama wani zaɓi mai inganci kuma mai tasiri, musamman ga wadanda suka sake dawowa da cutar .
- Splenectomy: Kamar sauran nau'o'in NHL, marasa lafiya tare da WM na iya samun girma mai girma, ko kuma ɓarna. Wannan ya haifar da ƙaddamar da lymphocytes a cikin rami. Ga wasu marasa lafiya, cirewa daga ƙuƙwalwa, ko ɓarna, zai iya bada remission daga WM.
- Watch kuma Jira: Har sai WM yana haifar da matsalolin, mafi yawan likitoci zasu fita don kulawa da "kula da jira". A wannan yanayin, kwararrunku za su ci gaba da kulawa da ku kuma jinkirta karin hanyoyin kwantar da hankula (da kuma halayen dangin ku) har sai kun buƙatar su. Ko da yake yana da wuyar tunanin tunanin rayuwarku ta yau da kullum tare da ciwon daji a jikinku. ba yin wani abu game da shi ba, bincike ya nuna cewa marasa lafiya da ke jinkirta jinkirin har sai sun fara samun matsaloli daga gare ta ba su da mummunan sakamako fiye da wadanda suke fara magani ba da daɗewa ba.
Girma shi Up
Waldenstrom macroglobulinemia, ko WM, wani nau'in NHL ne da ya fi dacewa wanda aka gano kawai a kimanin mutane 1,500 a kowace shekara a Amurka. Yana da ciwon daji wanda ke rinjayar lymphocytes na B kuma yana haifar da mummunan yawan adadin anti-IgM a jini.
Domin ba haka ba ne, kuma saboda ilmin ilimin lymphoma yana ci gaba da fadadawa, babu wani tsarin kulawa na yau da kullum don WM. Saboda haka, mutane da yawa marasa lafiya da aka saba samu tare da WM suna ƙarfafa su shiga cikin gwaje-gwaje na asibiti don taimakawa masana kimiyya suyi koyo game da wannan ciwon daji na jini, kuma suna fatan za su sami damar yin amfani da magungunan yanzu wanda zai zama misali a cikin nan gaba.
Sources
Bachanova, V., Burns, L. Hematopoeitic Stem Cell Transplantation ga Waldenstrom Macroglobulinemia. Journal of Bone Marrow Transplantation Maris 2012. 47: 330-336
Dimopoulos, M., Kastritis, E. da kuma I. Ghobrial. Macroglobulinemia na waldenstrom: hangen nesa a cikin zamanin magunguna. Annals na Oncology . 2016 27 (2): 233-40.
Hillman, R., Ault, K. (2002) Hematology a Clinical Practice 3rd Edition. McGraw- Hill: New York.
Kristinsson, S .; Landgren, O. Menene ya sa Macroglobulinmia ta Waldenstrom: Halittu ko abubuwan da suka shafi kwayoyin cutar, ko hadewa? Clinical Lymphoma Myeloma da cutar sankarar bargo a watan Oktoba 2011. 11: 85- 87.
Oza, A., da S. Rajkumar. Waldenstrom macroglobulinemia: fassarar da kuma gudanarwa. Ciwon Kankara ta Blood . 2015. 5: e296.
Tedeschi, A. Benevolo, G., Varettoni, M., Battista, M., Zinzani, P., Visco, C., Meneghini, V., Pioltelli, P., Sacchi, S., Ricci, F., Nichelatti , M., Zaja, F., Lazzarino, M., Vitolo, U., Morra, E. Fludarabine da cyclophosphamide da rituximab a Waldenstrom macroglobulinemia. Kankara Janairu 2012. 118: 434-443.