Gonadotropin Sakamakon Hormone Agonists (GnRH)
Tambaya: Mene ne Gonadotropin Gone Hormone Agonists (GnRH)?
Amsa: Gonadotropin watsar da agonists na hormone (GnRH) wani nau'i ne na magani wanda ya hana kwayoyin halitta ta hanyar dakatar da samar da estrogen da progesterone.
Gonadatropin-Releasing Hormone wani yanayi ne na yanayi wanda yake faruwa a jiki. An sake shi ta hypothalamus kuma tana iko da sakin hormone mai tayar da hankali (FSH) da kuma hormone luteinizing (LH) daga gland shine.
Wadannan hormones FSH da LH sa'an nan kuma karfafa da samar da estrogen da progesterone a cikin ovaries. Wannan dangantaka ce da aka sani da matsayi na ovarian hypothalamic wanda ke sarrafa jigilar ku .
Domin ya kamata wannan aikin ya yi aiki da kyau kuma ya haifar da samfurin GnRH dole a saki shi a cikin wani tsari mai kwakwalwa. Idan wannan wuri yana aiki yadda yakamata za ku sami lokaci na lokaci idan ba ku da ciki lokacin da kuka yi aiki.
Kwayar magunguna da ake kira GnRH agonists sunyi amfani da wannan buƙatar ƙwayar cutar GnRH. Sakamakon magani yana haifar da ci gaba da cigaba da glandan pituitary. Da farko za'a iya samun raguwa na FSH da LH amma to amma barancin GnRH zai haifar da gland shine ya daina samar da FSH da LH, wanda hakan ya kawo karshen aikin hormone a cikin ovary.
Gwanayen GnRH guda uku da aka saba amfani dashi a cikin aikin asibiti sune:
Lupron-leuprolide
Zoladex- goserelin
Synarel- nafarelin
Leuprolide da goserelin ana gudanar da su ta hanyar allurar rigakafi a kowane makonni 4 ko makonni 12 yayin da nalan din ke gudana ta hanyar yaduwa na hanci sau 1-2 a kowace rana. Yawancin mata za su fuskanci yunkurin maganin ovel ta mako huɗu kuma kusan dukkanin mata zasuyi bayan makonni takwas na magani.
Saboda GnRH agonists na dan lokaci kashe wayarka na ovaries da estrogen da progesterone wannan nau'i na magunguna ana amfani dasu don biyan wasu ka'idodi a cikin mata da ke da isrogen da progesterone dogara. Wadannan sun haɗa da:
Endometriosis
Uterine Fibroids
Gudanar da zub da jini mai tsanani
Mutuwar Premenstrual cuta / Sashin ciki na dysphoria
Rashin rashin lafiya
Akwai kuma wasu shaidun da suka bayar da shawarar cewa GnRH agonists na iya taimakawa wajen kare aikin mata na mata da ke shan maganin cutar kanjamau don ciwon nono.
Wadannan magunguna suna da mahimmancin zaɓin magani. Abin takaici suna da wasu tasiri masu tasiri. Domin sun hana kajin na ovaries na hormones sakamakon illa na GnRH agonists sunyi amfani da alamar cututtuka na menopause. Wadannan sakamako sun hada da:
Hotuna mai haske - mafi yawancin sun ruwaito cikin kashi 80% na mata
Rashin ƙarancin ruwa
Rage libido
Ciwon kai
Wulo
Matsayin da ke ciki
Rage yawan ma'adinai na nama
A bayyane yake alamun cututtukan mazaopausal basu da kyau amma mafi yawan game da sakamako na gefe shine asarar ƙananan ma'adinai. Gaba ɗaya asarar kasuwa yana juyawa bayan magani ya tsaya amma a cikin ƙananan mata wannan asarar kasuwa bazai iya sake dawo dasu ba.
Don hana asarar kashi da ke hade da GnRH jiyya likita zai iya tsara wani progestin ko hada haɗin estrogen da progestin.
An san wannan a matsayin ƙara farfadowa kuma an nuna shi mai tasiri ne don hana hasara na haɗuwa tare da yin amfani da GnRH agonists. Hakanan zai iya taimakawa rage ƙananan fushin zafi.
Updated by Andrea Chisholm MD
Magnon N.Gonadotropin sake watsar da agonists na hormone: Ƙara fadada vistas; Littafin Indiya Endocrinology Metabolism. 2011 Oktoba-Dec, 15 (4): 261-267