Cutar cutar Alzheimer ita ce irin ciwon ci gaba wanda ke shafar fiye da miliyan 5 na Amirka, kuma ana kiyasta waɗannan rates don ƙara ƙaruwa a cikin shekaru masu zuwa. Wata hanyar haɗakar cutar Alzheimer wadda masu bincike ke nazarin shine ciwon sukari. Akwai darussa da yawa da suka haɗa da cututtuka biyu tare. A gaskiya ma, wasu masu bincike sun fara kiran cutar Alzheimer "irin 3 ciwon sukari".
Kodayake ƙananan binciken da aka gano sun kara yawan ciwon sukari tare da ciwon sukari iri iri, yawancin karatun sun ƙaddara cewa wannan haɗin tsakanin masu ciwon sukari da kuma Alzheimer na musamman ne game da ciwon sukari .
Abun ciwon sukari na 2 yana tasowa lokacin da insulin ya zama kasa da kyau a sukari sugar ta wurin jini. Nazarin ya nuna cewa kusan rabin mutane masu ciwon sukari na 2 za su ci gaba da cutar Alzheimer. Tare da irin wannan haɗin gwiwa, mayar da hankali ga wasu nazarin bincike shine ya bayyana dangantakar tsakanin cutar biyu.
Rubutun 3 Ciwon sukari
A cikin ciwon sukari na 1 ko 2, ba a isar da insulin (ko babu wani abu) don aiwatar da glucose (sukari) daidai ko jiki baya amsa maganin insulin, kuma yana shafar aikin a jikin jikin. A cikin cututtukan Alzheimer, yana bayyana cewa matsalar ta da ke faruwa, amma maimakon haifar da matsala a cikin aikin jiki duka, sakamakon yana faruwa a kwakwalwa.
Masu bincike sun gano shaida mai ban sha'awa akan hakan yayin da suke nazarin kwakwalwar mutane bayan mutuwarsu. Sun lura cewa jinin wadanda ke da cutar Alzheimer wadanda ba su da nau'in cututtuka 1 ko iri 2 sun nuna yawan abubuwan da ke cikin wadanda ke fama da ciwon sukari, ciki har da ƙananan insulin a kwakwalwa.
Wannan ya haifar da masu bincike don gane cewa mai yiwuwa Alzheimer na ainihi ne irin ciwon sukari wanda suke kira "ciwon sukari na 3".
A cikin ciwon sukari, idan masu ciwon sukari masu ciwon sukari sun yi yawa ko kuma maras kyau, jiki yana nuna alamun matsalar: sauye-sauye, rikice-rikice, rikicewa, da dai sauransu. A cikin cutar Alzheimer, duk da haka, maimakon waɗannan sakonni masu mahimmanci na matsala, aikin kwakwalwa da tsari ya ragu sosai a tsawon lokaci.
Lokacin da ƙungiyar masu bincike suka sake nazarin ilimin karatun da aka samu akan cutar Alzheimer da aikin kwakwalwa, sun lura cewa cutar da ta samu a cikin cutar Alzheimer ita ce cutar da ƙwaƙwalwar ƙwaƙwalwa ta hanyar amfani da glucose. Sun kwatanta wannan ƙetare tare da halayyar ganewa kuma sun lura cewa raguwa cikin aikin glucose ya dace da, ko kuma ya riga ya riga ya wuce, ƙananan haɓakar ƙwaƙwalwar ƙwaƙwalwar ajiya, ƙwaƙwalwar maganganu , canje-canje , da sauransu.
Bugu da ƙari kuma, masana kimiyya sun yanke shawarar cewa, yadda insulin ke aiki a cikin kwakwalwa yana damuwa, ba kawai ƙwarewar ƙwaƙwalwar kwakwalwa ba, girman da tsarin kwakwalwa ya ɓace-duk abin da ke faruwa kamar cutar Alzheimer ta ci gaba.
Shin Ciwon sukari na 2 yana haifar da cutar Alzheimer?
Bincike yana ci gaba game da wannan tambaya, amma binciken daya ya nuna cewa yayin da ciwon sukari ya fi ƙaruwa kuma yana taimakawa wajen ci gaba da cutar Alzheimer, watakila ba shine dalilin da ya sa ba.
A cikin wannan binciken, masana kimiyya suna ciyar da ƙwayoyi masu cin nama masu yawa wanda ya haifar da cigaba da ciwon sukari na 2. Sai suka yi nazarin ƙwayar mice kuma suka gano cewa yawancin yawan kwayoyin sunadaran sun kasance a cikin kwakwalwarsu, kuma ƙananan ƙwayoyin sun ƙaddamar da tsayayya ga insulin. Bugu da ƙari, tsarin kwakwalwa na wadannan ƙwayoyin ma ya ci gaba da ɓarna a kan abincin mai girma; duk da haka, aikin da ake amfani da waɗannan ƙwayoyin ba ya ƙin muhimmanci ga matakin da suke so ba idan cutar ta Alzheimer ta kasance.
Dubi Abin da ke Cutar cutar Alzheimer
Don haka, menene ya sa Alzheimer yayi idan ya kasance da ciwon sukari biyu ba shine mai laifi ba?
Masu bincike sunyi ƙoƙarin yin la'akari da ainihin dalilin cutar Alzheimer. Duk da yake suna iya gane shi a hankali tare da autopsy na kwakwalwa saboda sun san irin yadda yake da kuma yadda yake shafi tsarin kwakwalwar, ba su iya gane ainihin abin da ke haifar da canje-canje a cikin kwakwalwa ba ya lura a cikin Alzheimer's.
Masana kimiyya sun ƙaddara hanyoyi da yawa don rage yawan hadarin da ke tattare da cutar Alzheimer, ciki har da abinci mai kyau , aikin jiki, da kuma motsin zuciyar mutum, a tsakanin sauran mutane.
Shin magungunan ciwon sukari za su iya magance cutar Alzheimer?
Idan cutar Alzheimer ita ce wani irin ciwon sukari, shin magunguna don ciwon sukari zai taimaka wa mutanen da ke tare da Alzheimer ? Yawancin binciken bincike sun fara kallon wannan yiwuwar kuma suna nuna cewa wannan zai yiwu. A cikin duka dabbobi da na ɗan Adam, bincike ya nuna cewa wadannan magunguna sun kare kariya daga cututtuka da ke ci gaba da cutar Alzheimer, sun inganta ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwayar glucose, kuma sun nuna mahimmancin ci gaban kwakwalwa a wasu lokuta.
Sources:
Magungunan Magungunan Magunguna Wuta 14, Lamba 4, 2009. Rashin dangantaka tsakanin cutar Alzheimer da ciwon sukari: Rubutun 3 Ciwon sukari?
Alzheimer's Association. Cututtukan Alzheimer da Ciwon sukari na 2: Mene Ne Link? Afrilu 2011.
Tarihin Lafiya. 2012; 69 (1): 29-38. Cutar Intulinas na Inganci na Alzheimer da Rashin Ƙarƙashin Ƙarƙashin Lafiya.
Taron Duniya a kan Alzheimer ta Drug Discovery. Kamfanin Metabolic Solutions Development Company ya gabatar da samfurin Phase 2a na gwaji . Satumba 9, 2013.
Journal of Ciwon sukari Kimiyya da fasaha. 2008 Nuwamba; 2 (6): 1101-1113. Aka buga a cikin labaran 2008 Nuwamba. Cutar cutar Alzheimer na da nau'i 3 Ciwon sukari-Shaidun da aka Bincike.