Yaya Skin ɗinku da Shirye-shiryen Kasuwancin Aiki don Kula da ku lafiya
Kwayoyin Langerhans (LCs) suna cikin fata ( epidermis da dermis ) na sassan jiki na numfashi, ƙwayoyin narkewa da kuma nau'in urogenital. Za a iya samun su a cikin wasu nau'ikan takalma irin su lymph nodes, musamman ma lokacin da yanayin Lardin na Langerhans ya ƙunshi.
LCs na taimaka maka kare ka ta ajiye kwayoyi masu haɗari (duk abin da ke haifar da tsarin rigakafi don samar da kwayoyin cutar da shi) daga shiga jikinka.
Ta yaya aikin Langerhans Cells yake aiki?
Wani dan jarida mai kimanin shekaru 21, mai suna Paul Langerhans, ya gano shi a cikin 1868, kwayoyin Langerhans sun kasance a cikin dukkan nau'in epidermis kuma sun kasance mambobi ne na iyalin dendritic. Kwayoyin Dendritic sune kwayoyin halittar da ke nuna antigens zuwa tsarin da ba a rigakafi kuma ana samun su duka cikin jiki. LCs sune kwayoyin dendritic a cikin fata kuma tun da yake kwayoyin dendritic suna da matukar tasiri a faɗakar da tsarin rigakafi zuwa gaban pathogens da sauran kayan kasashen waje, fata shine muhimmiyar kariya ga kamuwa da cuta.
LCs sunyi zaton su zama wani ɓangare na tsarin jin dadi kuma kawai sun jijjiga tsarin rigakafi zuwa antigens. Maimakon haka, bincike ya gano cewa LC ta shafe fatawa zuwa kamuwa da kamuwa da cuta da kuma kumburi a hanyoyi 2 daban-daban:
- Ta kare jikinka daga kamuwa da cuta.
- Ta hanyar haɗarin rashin tausayi.
Kwayoyin Langerhans sun tura magungunan musamman - sunadarai kwayoyin halitta irin su tantus T da kuma B-nan da nan bayan sun gane kowane irin hatsari a fata.
Kwayoyin da ke dauke da kwayoyin halitta sun kama masu cin hanci irin su kwayoyin cuta da ƙwayoyin ƙwayoyin cuta kuma suna yaki akan raunin da ya faru kamar cututtuka.
Yanayin launi yana kula da shi kullum akan yanayin rashin lafiya kuma an aika da sassan kwayoyin cutar don dawo da bayanan game da duk wani ɓangare na kasashen waje. Sai jikin ya tara babban kundin kwayoyin cututtuka don yaki da mahaukaci ta hanyar haifar da wani abu mai rashin lafiyan ko yin amfani da kwayar cutar don kare shi daga kamuwa da cuta.
LCs da Skin Yanayi
Sabuwar bincike yana nuna cewa kwayoyin Langerhans suna iya ganowa da kuma kai farmakin ƙwayoyin cuta daga yanayin kewaye, don haka hana rigakafi. Wannan binciken cewa LCs yana da hannu wajen magance matsalolin cututtuka akan cututtuka daban-daban na iya sa su manufa mai yiwuwa don immunotherapy .
Wannan mahimmancin yana da yiwuwar canza matakan fahimtar hanyoyin da ke haifar da rashin lafiyar fata kamar:
- Psoriasis : Wani yanayin da kullun fata suke ginawa da kuma daidaitaccen ma'auni tare da wasu redness, itchiness da bushe.
- Lupus : Wani cututtukan cututtukan da ke fama da cututtuka sun faru ne lokacin da kwayar cutar ta haifar da kullun jikinta.
- Ciwon daji : Mafi yawan maganin Ciwon daji a Amurka, halin da ke ci gaba da ƙwayar jikin fata.
Akwai kuma yiwuwar ci gaba da maganin alurar rigakafin da aka yi ta cikin fata (magani na rigakafi) wanda ke mayar da hankali ga loading LCs kai tsaye cikin fata tare da antigens. Binciken ya rigaya yana kallon maganin alurar rigakafi da aka ba shi ta hanyar tsantsar fata don ya hana ci gaba da melanoma , irin mummunan ciwon daji na fata.
Menene Langerhans Cell Histiocytosis (LCH)?
Langerhans cell histiocytosis (LCH) wani rukuni ne na ƙwayar cuta, cututtuka na idiopathic wanda zai iya haifar da lalacewar fata, kasusuwa da sauran gabobin.
An cika yawan kwayoyin kama da LCs a cikin wannan cuta, duk da haka, ɓangarorin LCH suna nuna bambanci, hematopoietic (jini) sun samo asali ga cutar.
Sources:
Langerhans P. Über die Nerven der menschlichen Haut. Abubuwan Labaran Labaran [A] 1868; 44: 325-337.
Seo N., et al. Tsarin rigakafin cututtuka na peptide ta hanyar maganin rigakafi - rushe murfin murine don gwaji na rigakafi immunoprophylaxis. Sanar Natl Acad Sci USA 2000; 97: 371-376.
Yagi H., et al . Sakamakon samfurin lymphocytes na T tayi amfani da kwayar cutar ta TTT a cikin mutane ta hanyar maganin rigakafi na peptide. Cancer Res 2006; 66: 10136-10144.