Yaya wadannan kwayoyin suna da muhimmanci ga gano cutar
A cikin ilmin halitta da kuma magani, ma'anar "-blast" tana nufin ƙananan kwayoyin da aka sani da kwayoyin sunadarai ko ƙwayoyin sel. Zaka iya samun fashewar da ke haifar da dukkan nau'o'i daban-daban na musamman. Alal misali, neuroblasts zai haifar da jijiyar kwayoyin halitta kuma angioblasts suna haifar da kitsoyin mai. Kamar yadda ƙwayoyin tausayi da kitsoyin halitta ke samuwa daga kwayoyin da ba su da ƙwayar cuta, kwayoyin jini sun fito ne daga kwayoyin jini wadanda ba su da nakasarwa, ko busawa, a cikin kasusuwan kasusuwa.
Kwayoyin jini suna ci gaba da maye gurbin waɗanda suka tsufa ko suka tsorata.
To, me ya sa yake da muhimmanci a san game da fashewar? Musamman, ƙwayoyin ɓawon jini na karu?
Dukanmu muna da hargitsi. A gaskiya ma, mun fara tashi kamar yadda wani blastocyst ya zama daidai - jigilar kwayoyin halitta wanda ke raba lokaci mai yawa don zama tayi. Mene ne mahimmanci don sanin shine bayyanar irin bama-bamai a wurare da ba'a tsammani na jiki ko ci gaba da fashewar haɗari na iya zama alamar cutar ko ciwon daji.
Bone Marrow Cell Cells
A cikin kututture mai yalwacin jini, kwayoyin jini da ake kira da kwayoyin jini na hematopoiet ne suka zama cikin kwayoyin jini, jini mai launin jini, da kuma takarda ta hanyar tsarin da ake kira hematopoiesis . Wannan tsari yana faruwa a duk tsawon rayuwarka. Tsarin kwayar halitta ya zaɓi tafarkin cigabanta a cikin sassan layi guda biyu, layin lymphoid cell ko layin salula mai yaduwa . A cikin kwayar halitta mai suna myeloid, kalmar nan "ƙirar jini" tana nufin myeloblasts ko murmushi.
Wadannan su ne farkon farko kuma mafi yawan kwayoyin halitta na cellular myeloid.
Kodayake kwayoyin halitta na kwayoyin halittu sun kasance kimanin kashi 85 cikin kwayoyin jikinsu a cikin kututtukan kasusuwa, da kasa da kashi 5 cikin cikin kasusuwa na kasusuwa ya zama ƙwayoyin kamuwa.
Myeloblasts zai haifar da kukan jini . Wannan iyali na jinin jini yana dauke da neutrophils, eosinophils, basophils da monocytes, da macrophages.
Kasancewa da waɗannan ƙwayoyin mahaifa wadanda aka gano a cikin jini suna iya zama alama mai mahimmanci na wasu cututtuka irin su cutar sankarar myelogenous mai tsanani da ciwon mikilodysplastic.
Matsalar Myeloblast
A cikin yanayin cutar cutar sankarar mutelogenous (AML) da kuma methlodysplastic syndromes (MDS) , akwai ƙananan ciwon myeloblasts. Wadannan kwayoyin basu iya inganta kara cikin jinsunan jinin tsararru.
Murawon cutar sankarar myeloid mai muni shine irin ciwon daji da dama da wasu sunaye, kamar myelocytic cutar sankarar bargo, mummunan cutar sankarar rigakafin myelogenous, m cutar cutar sankarar granulocytic mai tsanani, mai cutar marasa ciwon lymphocytic mai tsanani, ko wani lokaci kawai AML. Yana da yawanci a cikin tsofaffi. Yawancin lokuta na AML da ke samuwa daga sel wanda zai zama jini mai tsabta banda lymphocytes, duk da haka, wasu lokuta na AML ci gaba a cikin wasu nau'in jini.
Sashin ciwon myelodysplastic wani rukuni ne na rikitarwa wanda ke rinjayar samar da sabon jini a cikin kututtukan kasusuwa. A cikin wadannan cututtuka, ƙwayar nama na haifar da ƙwayoyin ƙwayar cuta waɗanda ba su iya girma sosai kuma basu iya aiki.
Wadannan haɗari na haɗari sun fara kama da kasusuwan kasusuwa kuma sun hana samar da isasshen lambobi na sauran kwayoyin jini, irin su platelets, jini da jini, da kuma kodayen jinin lafiya.
A gaskiya ma, samar da ƙananan leukemic zai iya zamawa daga hannun cewa kwayoyin halitta ba tare da wanzuwa ba daga cikin kasusuwa cikin kasuwa. Kasancewar ƙwayoyin ƙwayar cuta a cikin ƙimar jini (CBC) saboda haka shine mai dadi sosai don cutar sankarar bargo. Kwayoyin bala'i ba a samo su ba ne a cikin jinin mutane masu lafiya.
> Sources:
> Cibiyar Ciwon Ƙwayar Yammacin Amirka. Ta Yaya Yaduwar Cutar Kankarar Muraya Mai Misa A Yayi? Fabrairu 22, 2016.
> Larson RA, Le Beau MM. Sanin kwayar cutar da farfadowa lokacin da cutar sankarar rigakafi da ƙwayar cutar ta kamu da ƙwayar cuta mai kyau. Rundunar Jarida ta Jaridar Hematology da cututtukan cututtuka . 2011; 3 (1): e2011032.
> Zahid MF, Parnes A, Savani BN, Litzow MR, Hashmi SK. Abubuwan da suka danganci miiloid neoplasms - menene muka koya har yanzu? Jaridar Duniya ta Tsarin Saka . 2016; 8 (8): 231-242.
> "Binciken cikakken bayani game da Hematopoiesis da Immunology: Abubuwan da ke faruwa ga masu sauraro masu satar kwayoyin Hematopoietic" a cikin Ezzone, S. (2004) Harshen Hematopoietic Stem Cell Transplantation: Jagorancin Nursing Society: Pittsburgh, PA (pp.1-12).