Yayin da jini ke bunkasa, rassan "iyalai" daban-daban sun tashi daga jikin kwayoyin jini. Tsarin layin kwayoyin halitta yana wakiltar irin wannan iyali. Sel a cikin layin kwayoyin halitta sune wadanda ke fitowa daga cikin kwayoyin halitta mai suna Myeloid, kuma zasu zama kododin jini wanda aka nuna a nan:
- Basophils
- Neutrophils
- Eosinophils
- Monocytes (a cikin jini)
- Macrophages (gabatarwa a cikin kyallen takarda)
- Erythrocytes (jan jini)
Saboda haka, kowane nau'in tantanin halitta a sama yana wakiltar samfurin karshe ko sakamakon karuwa a cikin iyalin myeloid.
Wannan sashin kwayar halitta ne wanda ke cikin "mummunan yanayi" kamar cutar cutar sankarar mutelogenous (AML) , wadda ke da yawan yawan asibitoci a kowace shekara, da kuma cutar cutar sankarar jini (CML) , wadda take da kimanin 6,660 sababbin bincikar cutar a cikin shekara a Amurka.
Abubuwa
Kwayoyin Red , da jini na jini, da kuma takaddun shaida duk suna da tsinkayen rayuwa, kuma an maye gurbin su gaba daya. Kwayoyin jiki na jini-suna zaune a mafi yawan kashi a cikin kututture a cikin tsofaffi - ninka da samar da mutane daban-daban, ko jinsi na sel.
Duk kwayoyin jini masu tasowa zasu iya gano jigon su zuwa wani nau'in tantanin kwayar halitta, wanda yake dauke da kwayoyin kwayoyin hematopoietic (HSC), wani abu akan "Adam da Hauwa'u" daga dukkanin jini.
Wadannan kwayoyin halitta sun rarraba - duka biyu don yin maye gurbin kansu da kuma samar da "kwayoyin halitta". Daga cikin zuriyar HSC, to, suna da nau'o'i daban-daban na kwayoyin halitta: akwai mahaifiyar lymphoid na kowa da kuma dangin myeloid na kowa. Wannan yatsa a hanya tsakanin lymphoid da linear myeloid babban abu ne.
Kowace mahaifa zai iya haifar da iyalansa masu rarrabe na jini. Kwayoyin jinin jini da aka sani da lymphocytes suna bunkasa daga zuriya na lymphoid, yayin da jini daban-daban na jini, da jini mai launin jini da kuma platelets da ke bunkasa daga masu haifar da myeloid. Sel na layin myeloid yakan kasance kimanin kashi 85 cikin dari na kwayoyin halitta, a cikin duka.
Myeloid Malignancies
A cewar Cibiyar Cancer na Amirka, yawancin marasa lafiya da cutar cutar sankarar myeloid mai zurfi (AML) suna da nauyin fararen fata marar tsabta a cikin jini, kuma basu isa jini ko jini ba. Yawancin kwayoyin jinin jini na iya kasancewa mahaifa - sau da yawa kawai ake kira hargitsi - waxanda suke da kwayar jini wadanda ba a gano su ba a cikin jini. Wadannan kwayoyin halitta ba sa aiki kamar al'ada, Kwayoyin jinin fararen fata.
Yawancin marasa lafiya da cutar cutar sankarar myeloid na kullum (CML) suna da nauyin jini mai yawa da yawa da yawa, wadanda basu da yawa. Wasu daga cikin nau'ikan kullun marasa tsabta na iya zama maɗuwa amma yawanci suna a cikin ƙananan lambobi fiye da AML. Wani lokaci CML marasa lafiya na iya samun ƙananan jini ko jini.
A cikin duka AML da CML, ƙididdigar jini zai iya zama da yaduwa game da cutar sankarar bargo, amma ilimin likitanci na ainihi yana buƙatar ƙwayar kwayoyin halitta da aspirate da sauran gwaje-gwaje.
Sources
Krumsiek J, Marr C, Schroeder T, et al. Bambancin Hanya na Ma'aikatan Myeloid An sanya shi a cikin Siffar Faɗakarwar Faɗakarwa. PLoS Daya. 2011; 6 (8): e22649.
Ƙara CJ. Hematopoietic suma kwayoyin halitta: manufofin, fassarori, da kuma sabon gaskiya. Jinin jini . 2015; 125 (17): 2605-2613.
Orkin SH, Zon LI. Hematopoiesis: Tsarin Halitta don Yarda Kwayoyin Halitta. Cell . 2008; 132 (4): 631-644.
Jagannathan-Bogdan M, Zon Li. Hematopoiesis. Ƙaddamarwa (Cambridge, Ingila) . 2013; 140 (12): 2463-2467.
Cibiyar Cancer na Amurka. Yaya aka gano cutar cutar sankarar myeloid mai tsanani? An shiga watan Disamba na 2015.
Williams, L. "Binciken Mafi Girma game da Hematopoiesis da Immunology: Abubuwan da ke faruwa ga masu sauraro masu satar kwayoyin Hematopoietic" a cikin Ezzone, S. (2004) Harshen Hematopoietic Stem Cell Transplantation: Jagorancin Nursing Society: Pittsburgh, PA (pp.1- 12).