Idan cholesterol ya kasance matsala a gare ku, likita zai iya gaya muku game da Zetia (ezetimibe) ko Vytorin (ezetimibe da simvastatin). An gina Vytorin a matsayin haɗin Zetia da Zocor (simvastatin), wanda aka nufa don bunkasa kayan haɓakar cholesterol-Zocor.
Gyara? Ka tuna cewa Zocor mai sauƙi ne - irin miyagun ƙwayoyi wanda yake aiki a hanta don hana cholesterol daga farawa.
Zetia wata sabuwar magani ce, ta ci gaba da hana ƙin cholesterol daga abinci a cikin hanji. Vytorin hade ne da Zocor da Zetia.
An gabatar da Vytorin ga jama'a a shekara ta 2004 ta hanyar tallan talabijin wanda ya yi ikirarin cewa Vytorin zai iya yaki da tushen maganin cholesterol biyu: abinci da kwayoyin halitta. Vytorin ya shiga jigilar kwayoyin cholesterol wanda ya riga ya samuwa a kasuwa, amma ga farashin ƙananan farashi. Duk da haka, sayar da kayayyaki na Zetia, sa'an nan kuma daga bisani Vytorin, da sauri ya samo asusun Amurka na cholesterol na wadannan kwayoyi.
Jarabawa na Gidan Gida Na da Sakamakon Gida na Zetia da Vytorin
Zama da Vytorin sun amince da su a farkon shekarar 2002 da 2004, saboda yadda zasu iya rage "mummunar cholesterol" ( LDL ). An kiyasta "mummunan cholesterol" wanda ke da alhakin gina allo a kan ganuwar waje wanda zai iya haifar da bugun jini ko ciwon zuciya.
A cikin Janairu 2008 , Merck / Schering Plow Pharmaceuticals - mai yin duka Zetia da Vytorin - sun fito da sakamakon binciken kan sakamakon haɗin hade da ƙananan simvastatin da simvastatin kadai akan tsarin atherosclerotic a cikin marasa lafiya tare da heterozygous iyalin hypercholesterolemia , da ake kira binciken HASKIYA.
Wannan binciken idan aka kwatanta da marasa lafiya 720 ko dai Vytorin ko Zocor kawai. Ta hanyar amfani da magunguna don bincika suturar karfin waɗannan marasa lafiya daga kungiyoyin biyu, masu bincike sunyi fatan ƙaddara idan magungunan hadewa, Vytorin, ya saukar da tasirin tasiri a cikin suturinsu.
Tsammani shi ne cewa wadanda ke dauke da Vytorin za su nuna cewa suna da kasa da yawa a kan ganuwar da suke kewaye da su fiye da wadanda suka kama Zocor kadai.
Maimakon haka, binciken binciken ya nuna cewa marasa lafiyar Vytorin basu da nauyin rubutu a cikin jigilar su fiye da waɗanda suka ɗauka kawai Zocor. A gaskiya ma, waɗanda suke ɗaukar Vytorin suna da ɗan ƙarami kaɗan.
Kyau mafi kyau a Nazarin Na biyu
Nazarin na biyu, wanda ake kira Ƙarƙashin Ragewar Gwaninta: Vytorin Efficacy International Trial (IMPROVE-IT), ya ƙaddamar da sakamakon a cikin marasa lafiya 18,000 da suka kamu da zuciya a baya. Sakamakon wannan binciken, ya ruwaito a shekara ta 2014, ya gano mafi yawan marasa lafiya a kan tsarin Vytorin ezetimibe / simvastatin sun cimma burin su na LDL-C da hs-CRP fiye da wadanda ke simvastatin kadai. Suna da kyakkyawan sakamako na kiwon lafiya idan sun sadu da makircinsu guda biyu, kamar yadda aka auna ta da cututtuka na zuciya, da magunguna, ko ciwon jini. Rashin haɗarin ciwon zuciya ta zuciya ko kuma bugun jini ya rage ta kashi 6%. Jinin da aka haɗu bai nuna babbar tasiri ba, musamman ga hadarin ciwon daji.
Wannan ya ci gaba da jayayya - yana da kyau a yi amfani da miyagun ƙwayoyi da ke sa labs dinka ya fi dacewa, amma yana da ƙananan inganta lafiyar lafiyarka, idan akwai?
Vytorin yana da gargadi da tsare-tsare da aka kara a shekarar 2010 kuma an sabunta akai-akai don yayi gargadin ƙara yawan haɗarin myopathy / rhabdomyolysis. Wadannan sun hada da gargaɗin wannan a cikin hulɗa tare da niacin da fibrates.
Dole in Dakatar da Karɓar Zaria ko Vytorin?
Ba haka ba. Bayan haka, marasa lafiyar Vytorin sunyi kyau sosai a wata ma'ana, wato, matakan rage yawan "cholesterol mummunan," wanda shine sakamakon da ya lashe FDA a farkon wuri. Idan aka kwatanta da marasa lafiya Zocor, marasa lafiya na Vytorin sun sami matukar muhimmanci a cikin matakan "mummunan cholesterol". Don me yasa marasa lafiyar Vytorin a cikin binciken sun kasance da matakan "ƙananan cholesterol" ba tare da wani cigaba ba a cikin ma'auni na wucin gadi ba a fahimta ba tukuna. FDA na ci gaba da binciken wannan shaida.
Amma game da Zetia, binciken da ya gabata ya nuna cewa wannan magungunan yana shafar ƙananan matakan cholesterol.
Ko da lokacin da ba tare da Zocor ba, wadanda marasa lafiya suna daukar Zetia suna da sakamakon da suka hana shayarwar cholesterol daga abincin da ke shiga cikin hanji.
Ƙungiyar Zuciya ta Amurka ta ɗauki nauyin a cikin al'amarin ta hanyar ba da shawara ga marasa lafiya da ke dauke da Vytorin kada su watsar da magani saboda hatsarin haɓaka ƙwayar lafiya daga rashin tsarkewar ƙwayar cholesterol. Ko da sauyawa zuwa wata magungunan miyagun ƙwayoyi bazai zama dole ba saboda wasu dalilai:
- Ko da tare da sakamako mai banƙyama a binciken farko, ba a nuna Vytorin ba mai lafiya ba.
- Statin da ke ƙunshe a cikin Vytorin yana da amfani sosai don yaki da cholesterol.
- Vytorin ko Zetia sunyi wajabta ga wasu marasa lafiya saboda Zocor ko wani statin kadai bai tasiri ba wajen rage "bad cholesterol".
- Magunguna daban-daban bazai kasance da shawara ga wasu marasa lafiya ba, saboda yanayin likita marasa dangantaka.
Abin da za a yi
Kamar yadda kullum, ya kamata ku duba tare da likitanku. Tambayi ko akwai yanayi wanda ya kamata ya ci gaba da kai a halin yanzu na magani ko kuma idan ya kamata ka fara gano wasu hanyoyi.
Idan likita ya ba da shawara cewa kayi tafiya tare da Vytorin ko Zetia, to, ya kamata ka:
- Ci gaba da biyan canje-canjen da ake bukata na salon cin abinci , motsa jiki da shan taba don kaucewa ƙwayar cholesterol.
- Ka kiyaye alƙawuranka kuma ka lura da kowane canje-canje a cikin rukunin kwamfutarka don sanin ko maganin likitanka yana aiki kamar yadda aka sa ran.
- Saka idanu da bayyanar da ke faruwa yau da rana da kuma bayar da rahoton duk wata illa da za ka iya fuskanta ga likitanka.
A nan akwai wasu tasiri masu tasiri na musamman don kallon yayin shan Vytorin:
- ciwon kai
- tsoka ko haɗin gwiwa
- rashin lafiyar jiki, ciki har da rashes ko kumburi
- bayyanar cututtuka na hanta ko gallbladder ƙonewa, ciki har da ciwo mai tsanani da ciwon zuciya da launin fatar jiki da launin fata daban-daban
FDA tana ci gaba da kimanta binciken da aka gudanar na binciken don sanin ko wani aiki ya dace. Idan kun yi imani cewa kun sha wahala daga illa mai lalacewa, ko kuma idan kun samu wani mummunan yanayi kamar ƙuƙwalwar zuciya ko bugun jini, yayin shan Vytorin ko Zetia, ana buƙatar ku da shi zuwa Gidan Rediyon Rahoton Abubuwan Hulɗa na MedWatch na FDA a kan layi.
Sources:
Ƙungiyoyin Ƙungiyar Zuciya ta Amirka. "Drug Far for Cholesterol." AmericanHeart.org . 4/21/2014. Ƙungiyar Zuciya ta Amirka. Fabrairu 11, 2016.
Ƙungiyoyin Ƙungiyar Zuciya ta Amirka. "Bayanin daga Cibiyar Zuciya ta Amirka game da sakamakon binciken binciken." AmericanHeart.org . 15 Jan. 2008. Kungiyar 'Yan Adam ta Amirka. 29 Mar 2008
Jackevicius, Cynthia. "Amfani da Ezetimbe a Amurka da Kanada." New England Journal of Medicine . 28 Mar 2008. New England Journal of Medicine. 3 Afrilu 2008.
Ma'aikatan Ciniki da Drug a Amurka, "Bayanan Farko game da Bayanin Bayanan Labarai na Ezetimibe / Simvastatin (kasuwa kamar Vytorin), Ezetimibe (kasuwa a matsayin Zetia), da Simvastatin (aka sayar da Zocor)." FDA.gov . 25 Jan. 2008. Abinci da Drug Administration na Amurka. 29 Mar 2008.
Ma'aikatan Cincin Abinci da Magunguna na Amurka, "Cikin Gidajen Gwaji: Gwaje-gwajen Masana'antu a cikin Mutane." FDA.gov . 1 Satumba 2003. Cibiyar Abinci da Drug ta Amurka. 3 Afrilu 2008
Ma'aikatan Abinci da Drug a Amurka. "Kamfanin Vytorin (ezetimibe / simvastatin)." FDA.gov . Fabrairu 2014. Abinci da Drug Administration na Amurka. Fabrairu 11, 2016.
Bohula EA, Giugliano RP, Cannon CP, Zhou J, Murphy SA, White JA, Tershakovec AM, Blazing MA, Braunwald E. Ci gaba da ƙwayar cholesterol da ƙananan zafin jiki na C-reactive. ezetimibe zuwa simvastatin da kuma dangantaka da sakamakon mafi kyau a cikin IMPROVE-IT. Yanayi. 2015 Satumba 29; 132 (13): 1224-33. Doi: 10.1161 / CIRCULATIONAHA.115.018381. Afub 2015 Satumba 1.
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