Ba sananne ba tare da Yanayin Flammatory
Platelets ne ƙananan raƙuman kwayoyin halitta wanda ke taka muhimmiyar rawa a cikin hemostasis (tsari na tsayawa zub da jini bayan rauni). Ba su da tsakiya amma suna dauke da cytoplasm da sunadarai masu mahimmanci don aiki na platelet. Ana samar da platelets ta hanyar megakaryocytes a cikin kututture.
Ana tasowa platelets a cikin rheumatoid arthritis .
Yanayin kayan ado mai mahimmanci da ake kira thrombocytosis.
A cikin rheumatoid arthritis, gidajen su ne tushen farko na lalacewa. Wannan shi ne inda ƙananan ƙumburi ke faruwa, ta haɗa da jini wanda ya hada da neutrophils da macrophages. Wadannan kwayoyin suna kuma daɗaɗa samar da kayan aiki mai nau'in platelet, wanda hakan zai haifar da tarawar talifin jini, ya ba su damar shiga cikin amsawar mai kumburi a jikin.
Platelets a Rheumatoid Arthritis
Mutane masu lafiya suna da ƙididdigar platelet a cikin al'ada na 150,000-400,000 / mm3. Kamar yadda shekarun 1972, an lura da shi a cikin wallafe-wallafe na likita cewa masu bincike sun sami tarin platinum mai daraja a kimanin kashi ɗaya cikin uku na marasa lafiya na wutsiya marasa lafiya.
An gano wannan a cikin haɗin kai tare da aikin cututtuka. Masu bincike kuma sun sami daidaituwa a tsakanin adadi mai mahimmanci da kuma anemia , leukocytosis (ƙara yawan jini), da kuma rheumatoid factor .
Akwai dangantaka mara kyau tsakanin hemoglobin da countlet count, ma'ana, lokacin da hawan hemoglobin ya ragu, adadin platelet yana da tsawo. Ƙungiyar sideropenia (nauyin baƙin ƙarfe) da kuma adadi na platelet ba a gano su da muhimmanci.
Wasu mutane masu fama da cututtuka mai tsanani suna iya samun platelet fiye da miliyan.
Lokacin da aka kawo rashin lafiya tare da magungunan, magungunan platelet yawanci ya koma al'ada.
Ana kwantar da platelets ba kawai a cikin arthritis na rheumatoid ba, amma har ma a wasu yanayi masu kama da kullun. An samu daidaituwa mai mahimmanci a tsakanin kullun da ke dauke da cututtuka. Sauran karin bayyanar cututtuka na rheumatoid (watau, shafi na jiki fiye da gidajen kwakwalwa) an samo mafi yawa a tsakanin mutanen da suka tada platelet.
Dalilin
Bayanin mafi kyau ga ƙwararren mai girma da aka ƙidaya a ƙwayar cututtuka na rheumatoid yana da alaka da cutar anemia na yau da kullum, siffar halayyar cututtukan arthritis na rheumatoid. Bisa ga Annals of the Rheumatic Diseases , platelet homeostasis ne ke sarrafawa ta thrombopoietin.
Thrombopoietin shine babban mai gudanarwa na bunkasa megakaryocyte da bambanci. Anyi zaton cewa thrombopoietin zai iya haɗuwa da shi zuwa erythropoietin (wani hormone da ke cikin aikin jini na jini), musamman saboda marasa lafiya na marasa lafiya wanda ke tare da reticulocytosis (ƙãra yawan yawan jinin jini) kuma ƙara yawan ƙwayar erythropoietin sun fi girma fiye da adadi na al'ada. Idan matakan erythropoietin sun karu a cikin mutanen da ke da cutar anemia da rheumatoid, ƙididdigar adadi mai girma zai iya haifar.
Wani yiwuwar zai kasance idan an kara yawan kayan platinum ta hanyar ƙara yawan lalacewa ko amfani. Masu bincike sun kuma bayar da shawarar cewa za'a iya haɗuwa da ƙwararren platelet mai mahimmanci a cikin maganin arthritis na rheumatoid-watakila saboda ƙananan ƙwayoyin cuta a cikin ƙananan ƙwayoyin cuta.
A cewar Kelley's Textbook of Rheumatology , akwai abubuwa uku da ke haifar da gagarumin platelet ƙididdigar a cikin cututtukan rheumatic:
- Sakamakon maganin thrombocytosis, na biyu zuwa ga tsarin kumburi na yau da kullum. A irin waɗannan lokuta, cytokines (IL-1, IL-6, da TNF) na iya kasancewa masu jarrabawa masu aiki a tsari na samar da platelet a yayin da ake cike da kumburi.
- Yayyancin thrombocytosis na iyali zai iya faruwa ne saboda maye gurbin maye gurbi.
- Clonal thrombocytosis (na farko ko muhimmiyar thrombocytosis) wani abu ne wanda ba shi da izini na cin abincin platelet saboda cigaba da bunkasa megakaryocyte.
> Sources:
> Hutchinson RM et al. Thrombocytosis a cikin rheumatoid arthritis . Annals na Rheumatic Diseases. (1976) 35: 138
> Kiraz S. et al. Bloodstream thrombopoietin a cikin rheumatoid arthritis tare da thrombocytosis, Clinical Rheumatology. 2002 Nov; 21 (6): 453-6.
> Kelley's Textbook na Rheumatology. Edition na tara. Babi na 17. Labari da Raunin Rheumatic. Pages 249-251.
> Thrombocytes a Rheumatoid Arthritis. Scandinavian Journal of Rheumatology. Selroos, O. 1972 1: 136.