Abubuwan da ke da amfani da kuma hanyoyin da ke cikin masu maganin maganin ƙwayar cuta
Mene ne kake bukatar sanin game da amfanin, alamomi, da kuma illa na Femara (letrozole) don ciwon nono?
Femara (letrozole) (wanda aka fi sani dashi kamar fimara, femarra, da femera) magani ne a cikin wani nau'in da aka sani da masu kwantar da aromatase. Wadannan kwayoyi sun hana jigilar estrogen da aka yi a yankunan da banda ovaries. Tun da estrogen zai iya zama abincin don ci gaba da ciwon nono, Femara yana taimakawa wajen rage ciwon daji na sake ciwon nono da kuma inganta rayuwarka.
Idan kana shan maganin sakamakon wannan magani, tabbatar da karantawa game da amfanin Femara da hanyoyi da za a iya gudanar da maganganu na wannan magani.
Drug Type
Femara ne mai maganin antiestrogen, ko mai gabatar da aromatase. Sauran masu hanawa na aromatase sun hada da Aromasin (exemestane) da Arimidex (anastrozole.) Femara ba steroid ne ba.
Hormone Far for Breast Ciwon daji
Nazarin ya nuna cewa yin amfani da maganin hormone don ciwon kwakwalwa na ciwon estrogen-tabbatacciyar ƙwayar cutar yana rage yawan hadarin sake dawowa kuma yana kara yawan rayuwa. Akwai nau'o'i na biyu na hormone ga wadanda ke fama da ciwon nono.
Kafin menopause, ovaries suna yawan yawan estrogen. Idan ovaries din ke aiki, ana amfani da Tamoxifen don hana yiwuwar estrogen don daura da kwayoyin cutar ciwon daji.
Bayan mazaunewa, ko masu yin jima'i na jiki, da mazauna mata, ko magungunan magungunan mata , su ne tushen asrogirin a cikin jiki wanda ya haifar daga ragowar androgens a wasu wurare na jiki.
Masu hana maganin rashin lafiya sunyi aiki don toshe wannan aikin wanda yayi tuba da androgens zuwa estrogens, don haka ya hana kasancewan estrogen.
Yadda Femara ke aiki don hana ƙwayar cutar ciwon ciki
Kamar yadda muka gani, bayan mazaunewa, ainihin tushen isrogen a cikin jiki shine abin da aka samar a cikin nau'in androgens a cikin jiki mai kyama cikin jiki.
Wadannan sunadarai ("hormones" namiji) suna canzawa zuwa estrogen a cikin wani motsin da aka haɓaka ta hanyar enzyme da ake kira aromatase. Ta hanyar hana aikin aromatase, ana samar da isrogen ne. Wannan yana haifar da rashin isrogen wanda yake samuwa a cikin jiki don tayar da dukkanin kwayoyin cutar ciwon daji ko ciwon daji (kwayoyin ciwon kwakwalwa mai cin gashin kwari mai suna estrogen).
Yaya magani yake da muhimmanci don rage hadarin ciwon daji na ciwon nono? Ga alama mun san wani wanda ke da ciwon nono wanda aka bi da shi amma ya kai shekaru ko ma shekarun baya. Ba mu san yadda waɗannan kwayoyin cututtuka za su iya kwanciya ba dadewa, amma akwai wasu ka'idojin da yasa cututtuka suka faru kamar yadda ciwon daji ke haifar da kwayoyin halitta wadanda suka fi karfi fiye da kwayoyin cutar Kanada. Kwanan baya yawanci ya fi dacewa da ciwon ƙirjin ƙirjin mai jijiyar estrogen-tabbatacce, yin bincike ga hanyoyin adjuvant irin su Femara haka mahimmanci.
A yanzu an ba da shawara cewa Zometa za a fara a lokaci daya kamar Femara ga wadanda ke fama da ciwon daji na maza da mata wadanda suka kammala aikin tiyata da chemotherapy (duba ƙasa).
Menene Bincike Na Faɗakar da Mu Game da Femara?
Ga matan da ke dauke da ciwon isrogen-certified cancer, da kuma karɓar adjuvant chemotherapy, jiyya tare da mai gabatar da aromatase ya nuna ya rage hadarin komawa zuwa kashi 50.
Nazarin da ke kallon matan da suka karbi shekaru 5 na Tamoxifen magani, sun gano cewa amfani da Femara bayan wannan lokaci, ko da farawa 'yan shekaru baya, ya haifar da inganta rayuwar.
Mata waɗanda suka zama mazaopausal a cikin shekaru 2 zuwa 3 a kan Tamoxifen farfesa kuma aka sauya su zuwa Femara ga sauran shekaru biyar, suna da mummunan haɗari na mata fiye da mata waɗanda suka ci gaba da amfani da Tamoxifen kadai don tsawon shekaru 5.
Ga matan da suka zama menopausal a farkon cutar magani, akwai karin amfani wajen yin amfani da masu ƙetare aromatase da farko fiye da farawa da Tamoxifen.
Ba'a san daidai lokacin tsawon lokacin da Femara ya nuna amfanin ba, a wasu kalmomi, ko amfani da Femara ko amfani ba tare da amfani da tsawon shekaru biyar ba. (Duba ƙasa.) Yi magana da likitan ilimin likitancinka kamar yadda wannan yankin yake canza game da shawarwarin yanzu.
Wanene zai iya ɗaukar shahara
Wannan miyagun ƙwayoyi ne ga matan da aka gano tare da ciwon ciwon ƙirjin mai ciwon isrogen. Dole ne mace ta kammala aikin kulawa ta farko kuma ta kasance cikin mazauni . Mata masu auren mata da maza zasu iya daukar Femara idan an kawar da ovaries su. Mata da suka samu ciwon jijiyar isrogen-korau marasa ciwon ba za su amfana daga wannan magani ba.
Hanyoyin Farko na Femara da Sauran Masu Rarraba Aromatase
Kamar yadda sauran magungunan, magungunan halayen sun kasance tare da Femara. Abubuwa masu rinjaye na yau da kullum sun fi zafi da tsoka da haɗin gwiwa. A gaskiya ma, tsoka da ciwon haɗin gwiwa yana daya daga cikin dalilan da ya fi dacewa da mutane suka dakatar da shan magani (duba ƙasa).
Har ila yau, hotuna masu zafi suna da yawa, duk da haka mutane da suka sauya daga tamoxifen zuwa Femara bayan sun zama dan kasuwa (saboda shekarun haihuwa, tiyata, ko magungunan mata) suna lura cewa hasken zafi ya fi karfi a Femara fiye da tamoxifen. Ko da yake wannan sakamako na gaba yana takaici, duk abin da ya rage isrogen a jikinmu zai iya haifar da hasken zafi, kuma rage estrogen shine hanya mafi kyau don rage hadarin komawa. Wasu mutane sun gano cewa yana da amfani wajen "ƙuƙama" kuma duba kullun zafi kamar alamar cewa magani yana aiki.
Sauran cututtukan da suka dace sun hada da ciwon kai, gajiya , hawan ƙarawa, da rashin barci). Koyi game da haɗarin rashin rashin barci ga marasa lafiya na ciwon daji kamar yadda zai iya rage yawan ciwon nono, amma za a sami zaɓuɓɓukan magani.
Masu haɗari na rashin lafiya zasu iya haifar da asarar kasuwa wanda zai iya haifar da osteoporosis , koda yake hadawar Femara tare da Zometa (shawarar da aka yi a 2017) zai iya cire wannan (duba ƙasa).
Masu hana masu kwantar da marasa lafiya ba su bayyana sun kara yawan hadarin zuciya da cututtuka dangane da amfani da tamoxifen amma suna haɗuwa da matsalolin zuciya mai tsanani irin su mahaukaciyar zuciya da pericarditis (ƙin ciwon zuciya)
A lokacin da za a yi la'akari da maganin Gyara
Abin takaici, ƙwayoyin tsoka da haɗin gwiwa sune maganin jiyya tare da Femara. A cikin wani babban binciken, an gano cewa kashi 32 cikin dari na marasa lafiya sun dakatar da yin amfani da wannan magani saboda sakamakon illa. Kusan kashi 24 cikin dari na mutane sun dakatar da magani saboda tsoka da haɗin gwiwa. Yana da mahimmanci a lura cewa daga cikin wadanda suka dakatar da maganin su na aromatase sakamakon sakamako masu illa, na uku ya iya jure wa ɗayan magunguna a cikin wannan magunguna.
Yi magana da likitanka game da abin da zaka iya yi don taimaka maka ka jimre tare da haɗin gwiwa da kuma tsoka. A cikin gwajin gwaji guda daya an gano cewa acupuncture ya fi taimakawa wajen shayarwar acupuncture a cikin sauya ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙananan aromatase.
Hakanan zafi zai iya zama m kuma ana sa ran tun lokacin da magunguna suke rage yawan samar da estrogen a jikinka. Bincika waɗannan tunani akan hanyoyin da za a magance matsalolin zafi.
Osteoporosis Rigakafin
Yin amfani da masu kwantar da ƙananan aromatase yana kara yawan asarar kasuwa kuma an lura cewa ba wai kawai ƙara haɗin osteoporosis ba amma yawan ƙwayar kashi tsakanin mata da suke amfani da kwayoyi. Yi magana da likitanku game da nunawa ga osteoporosis. Tabbatar cewa kuna samun cikakken bitamin D da alli. A gaskiya ma, darajar bitamin D a cikin jininka ko dangantaka da rayuwa mai ciwon nono, don haka magana da likitanka game da samun gwajin bitamin D naka, da abin da zaka iya yi idan matakin ya kasa.
Mutane da yawa masu ilimin likita suna bayar da shawarar yin gwaji mai yawa idan an fara amfani da ingancin aromatase, kuma daga baya daga bisani.
Amfani da Magana da Femara da Zometa da Kashe Kashe
Ga wadanda aka gano tare da masu ciwon magunguna na mata, wadanda masana ilimin likitancin jiki sun fara da Zometa bisphosphonate (zoledronic acid) a lokaci guda. Zometa ba kawai rage haɗarin asarar kasuwa da kuma osteoporosis tare da masu hanawa na aromatase amma ya rage hadarin sake dawowa.
Ciniki
Sakamakon sakamako na wucin gadi na Femara sun fi dacewa a yayin da ka san cewa haɗarin haɗari ya rage ƙwarai. Mata da suka dauki Femara bayan shekaru biyar na Tamoxifen suna da mummunar haɗari na sake dawowa da wadanda suka dauki shekaru biyar na Tamoxifen. Bugu da ƙari, tare da Femara, hadarin ku na sabon ciwon daji a cikin ƙananan ƙirjin ya kasa da Tamoxifen kadai.
Bayyana shawarwarin
Ɗauki Femara sau ɗaya a rana tare da ruwa. Wannan magani bai kamata a dauki shi ba tare da abinci. Yi ƙoƙarin ɗaukar shi a lokaci ɗaya a kowace rana, don kula da magungunan miyagun kwayoyi a cikin tsarinka. Idan ka rasa kashi, kada ka ninka sau ɗaya, kawai jira har sai gobe mai zuwa ka sake ci gaba da tsarin jimagin ku. Kada kayi amfani da wannan miyagun ƙwayoyi idan har yanzu kuna da matsala ko kuna da ciki.
Ana samuwa a matsayin kwaya 2.5 mg, sunan iri (babu jinsin samfurin da aka samo), da takardar izini kawai.
Ya kamata a yi amfani da Femara a tsawon tsawon shekaru biyar?
Shawarar da aka yi game da lokacin mafi ƙarancin Femara (da sauran masu hana masu aromatase) ana tattaunawa a halin yanzu. Tun da farko shawarwari sun kasance na shekaru 5 bayan na farko magani tare da tiyata kuma yiwu chemotherapy da / ko radiation far but wannan na iya canza.
Lokacin da za a kira likitanku
Abubuwa mafi tsanani masu illa, irin su cututtukan zuciya, na iya faruwa a wani lokaci. Kwayar cututtukan da ya kamata ya jawo hankalinku don kiran likitanku sun hada da numfashi na numfashi, zafi ciwon zuciya, zafi ko ƙumburi, ƙananan jini na zubar da jini, fatar jiki , zazzabin jini, ko tashin hankali da kuma zubar da jini.
Layin Ƙasa
Idan aka yi amfani da su wajen bin magani na farko na ciwon daji (tare da tiyata, da kuma kwarewa da kuma / ko radiationrapy), Femara zai iya rage hadarin komawa. Sakamakon komawa baya ne kuma rashin lafiya, wanda shine ainihin dalilin mutuwa daga ciwon nono.
Femara ne aka nuna wa mata masu auren mata da maza wadanda suka kasance masu aikin rigakafi amma suna da maganin farfadowa na mata. Abubuwa masu lahani na yau da kullum sun hada da walƙiya mai zafi da tsoka da ciwo. Yawancin cututtukan da suka faru kamar cutar cututtukan zuciya da osteoporosis na iya faruwa. Tare da kariyar farfesa bisphosphonate, duk da haka, haɗarin hasara kashi zai bayyana.
Ana bada shawara ga Femara aƙalla shekaru 5 bayan kulawa ta farko, amma binciken na baya-bayan nan yana nuna cewa amfani da tsawo zai iya bada shawara a nan gaba.
> Sources
> Dhesy-Thind, S., Fletcher, C., Blanchette, P. et at. Amfani da Bisphosphonates Adjuvant da sauran Ma'aikata Masu Saukewa a Cikin Cancer Abinci: Ciwon Daji na Ciwon Daji Aikin Ontario da Amirka na Cibiyar Nazarin Harkokin Kwayoyin Kwayoyin Kwayoyin Hoto. Journal of Clinical Oncology . 2017. 35 (18): 2062-2081.
> Hague, R., Shi, J., Schottinger, J., et al. Kwayar cutar kwakwalwa Bayan Bayanin Aromatase Use. JAMA Oncology . 2 (12): 1590.
> Halsey, E., Xing, M., da R. Stockley. Acupuncture don alamun haɗin gwiwar da ke shafi likitancin maganin aromatase a cikin 'yan mata postmenopausal da ciwon daji na farko-da-wuri: nazari. Acupuncture a Medicine . 2015. 33: 188-195.
> Henry, N., Azzouz, F., Desta, A. et al. Mawallafi na Aromatase Inhibitor Discontinuation a matsayin Result na Jiyya-Cutar Gidaji na Farko a Tsarin Farko Cutar Kankara. Journal of Clinical Oncology . 2012. 30 (9): 936-942.
> Senkus, E., Kyriakides, S., Ohno, S. et al. Babban ciwon nono na nono: Jagoran Harkokin Kasuwanci na ESMO don ganewar asali, jiyya da biyo baya. Annals na Oncology . 2015. 26 (maimaita 5): v8-v30.