Magungunan Halittu na Halitta Ba Daidai Ba Ne Ga Mutum Mai Mutum
TNF (ƙananan ƙwayoyin necrosis factor) blockers ya zama zabin mai magani ga marasa lafiya da cututtuka na huhu ko wasu cututtukan cututtuka irin na arthritis da suka fara a 1998 lokacin da Enbrel (anancept) ya amince da FDA. Yawancin magungunan kwayoyin halitta sun riga sun yarda da kasuwa.
Ma'aikata na TNF sun hada da, Enbrel (akida), Saurara (ƙananan), Humira (adalimumab), Simponi (golimumab) da Cimzia (certolizumab pegol).
Akwai kuma wasu kwayoyin halitta, irin su Orencia (abatacept), Rituxan (rituximab), Actemra (tocilizumab), da kuma Kineret (anakinra) wanda basu dame TNF ba.
Idan ana bi da ku tare da mai tsaro na TNF, zai iya zama wajibi don canzawa zuwa wani mai tsaro TNF daban-daban ko wani magungunan kwayar halitta a wasu wurare. Dalili na dace don sauyawa sun haɗa da:
- Amsar da ba ta dace ba ga magani
- Sakamakon sakamako masu illa marasa amfani
- Ya rage tasiri a kan lokaci
Mun tambayi masanin ilimin rheumatologist Scott J. Zashin, MD wasu 'yan tambayoyi game da sauyawa majinjin TNF.
- Shin mai yiwuwa ne mai haƙuri ya sami mafi kyawun amsa ga wani mai tsaro TNF daban ko dukansu duka?
- Shin mai lafiya zai iya komawa a kan mai tsaro na TNF bayan ya tsaya shi?
Dr. Zashin ya amsa ya ce, "Akalla kashi 70 cikin dari na marasa lafiya da cututtuka na rheumatoid da suka fara daya daga cikin masu tayar da TNF zasu sami matukar cigaba a yanayin su. Har ma mafi yawan marasa lafiya zasu sami amfana idan tsarin (Rheumatrex, Trexall) ko wani DMARD (gyaran cutar anti-rheumatic magani) an hade tare da TNF blocker.
Idan mai haƙuri ba ya amsawa ga mai tsaro TNF na farko bayan watanni 3, sauyawa zuwa wani zai ƙara damar yin amfani. A gaskiya ma, ko da wanda ya kamu da rashin lafiya ya amsa wa biyu daga cikin magungunan TNF, zai iya zama da amfani a gwada na uku. "
A gaskiya, sakamakon binciken (aka buga Yuni 2010 a Rheumatology) ya tabbatar da cewa marasa lafiya da spondyloarthritis wadanda basu kasa amsawa da Enbrel na Remicade a matsayin wakili na farko ba, sun amsa da Humira bayan da suka sauya, ko da kuwa me ya sa aka sauya su.
Wani nazari mai ban sha'awa, wanda aka wallafa a cikin Clinical Rheumatology a shekara ta 2013, ya bayyana cewa marasa lafiya tare da spondyloarthritis sun iya cigaba da tsawon lokaci tare da masu tarin fuka TNF fiye da marasa lafiya na wutsiyoyin jini, musamman saboda raunin spondylitis subgroup na marasa lafiya. Tare da maganin arthritis da kuma spondyloarthritis, marasa lafiya sun iya zama tare da Enbrel da Humira fiye da misalin Remicade.
Dokta Zashin ya kara da cewa, "Mafi yawan masu ilimin lissafi ba su yi amfani da Kineret ba don magance cututtuka na rheumatoid saboda rashin tasirinta kuma yana buƙatar yin amfani da shi kowace rana.Yan da haka, Kineret ya kasance da amfani sosai a cikin marasa lafiya wadanda aka gano da tsarin maganin ƙwayar ƙananan yara, ake kira Har yanzu cutar . "
Har ila yau, a cewar Dokta Zashin, yayin da marasa lafiya da suka dakatar da magani tare da Enbrel da Humira na iya komawa kan miyagun ƙwayoyi ba tare da damuwa ba, waɗanda suka kashe Remicade don tsawon lokaci suna fuskantar haɗarin jigilar haɗuwa wanda zai iya zama haɗari.
Sources:
Sauyawa daga ƙananan ƙwayoyin cuta ko ƙananan hanyoyi zuwa adalimumab a cikin marasa lafiya ko marasa lafiya wanda ba tare da yaduwa ba tare da spondyloarthritis: nazarin shekaru 4. Spadaro. A. et al. Rheumatology (Oxford). Yuni 2010.
http://www.ncbi.nlm.nih.gov/pubmed/20223813
Drug rayuwa ta farko na magungunan TNF a marasa lafiya da cututtuka na rheumatoid da ƙananan spondyloarthritis: bincike daga cibiyar bincike na MonitorNet. Scire CA et al. Rheumatology Clinical da gwaji. Nuwamba-Disamba 2013.
http://www.ncbi.nlm.nih.gov/pubmed/23981363
Amsa, a cikin wani ɓangare na Scott J. Zashin, MD, masanin farfesa a asibiti a Jami'ar Texas na Makarantar Koyar da Ƙasar Kudancin Texas, Division of Rheumatology, a Dallas, Texas. Dokta Zashin kuma likitan likitanci a asibitin Presbyterian na Dallas da Plano. Ya kasance abokin tarayya na Cibiyar Kwalejin Kwararrun Amirka da Kwararrun Rheumatology na Amurka da kuma memba na Ƙungiyar Magunguna ta Amirka. Dokta Zashin shine marubucin Arthritis Without Pain - Miracle of Anti-TNF Blockers da kuma co-marubucin Magungunan Arthritis Jiyya.