Sabon Kayan Gidajen Magungunan Sclerosis
Idan ka sha wahala daga MS ko kuma ka sami ƙaunatacciyar ƙauna, mai yiwuwa ka yi amfani da lokaci mai tsawo tunani, fata, ko yin addu'a don magani mafi kyau, ko da magani. Labari mai dadi shine akwai adadi mai yawa na hanyoyin kwantar da hankalin MS wanda ake nazarin yanzu, duka a cikin layi da kuma gwaji. Ɗaya daga cikin ci gaba mai tasowa ci gaba shine cigaban maganin MS.
Rarrabe wani kwayar cutar MS daga wasu maganin rigakafi
Lokacin da kake tunanin maganin alurar riga kafi, yawancin mu na tunani kan mirgina hannayenmu don samun allura wanda zai hana mu samun mummunan cututtuka, irin su mura, kyanda, ko rubutun jini. Wadannan alurar sun ƙunshi ƙwayoyin cuta ko kwayoyin da aka raunana ko kuma suka kashe don kada su sa mu da lafiya sosai, amma munyi tsarin tsarinmu na rigakafi don samar da amsa.
Amma manufar maganin rigakafi na MS ba zai zama m. Maimakon haka, ƙwarewar zata zama warkewa. Wannan na nufin za'a ba shi don hana ko rage girman ƙwayoyin cututtukan MS da matsalolin kiwon lafiya a cikin mutumin da aka riga an gano shi tare da MS.
Wani bambanci tsakanin maganin gargajiya da kuma dan takarar kwayar cutar MS shine an tsara maganin rigakafin gargajiya don hana cutar cututtukan - wato, cutar da ke haifar da kamuwa da kwayoyin halitta na waje, irin su ƙwayoyin cuta ko kwayoyin cuta.
Duk da haka, MS ba cutar bane. Maimakon haka, MS shine cutar marasa lafiya. Don wasu dalili, tsarinmu na rigakafinmu yana kai hari ga magunguna da ƙwayoyin jijiya a cikin tsarinmu na tsakiya . A wasu kalmomi, MS ta haifar da wani abu da jikinmu yake yi wa kanta, kuma ba ta haifar da wani ɓangare na kasashen waje ba.
Sabili da haka, sassan wajan ƙwayar magungunan MS ba kwayoyin halitta bane amma wasu abubuwa da aka tsara don "tweak" tsarin mu na rigakafi a hanyoyi daban-daban don dakatar da kwayoyin halittarmu daga mummunan kwakwalwarmu da na kashin baya.
Mene ne Maganin Rigakafin MS da ke Nazarin?
A nan an gwada 'yan takara guda hudu daban-daban na kwayoyin MS: Tcelna, NeuroVax, BHT-3009, da RTL1000. Kowace wa] annan maganin ta amfani da wani matsala daban don cimma manufar dakatar da aikin kai tsaye game da myelin.
Tcelna (tsohon Tovaxin): Tcelna-wanda ake kira Tovaxin-wata maganin rigakafin T-cell ne, mai ma'ana cewa ya ƙunshe da kwayoyin T-cell na masu tasowa , waɗanda suke da alhakin kai hare-haren myelin a cikin mutane tare da MS, wanda aka kashe. Ta hanyar inject da babban kashi daga cikin wadannan cikin mutum, Tovaxin yana samun tsarin rigakafi don halakar da sauran wadannan kwayoyin halitta a wurare dabam dabam ba tare da fuskantar sauran tsarin ba.
An gano wannan alurar rigakafi don lafiya amma bai rage yawan adadin kwayar cutar gadolinium a cikin binciken kimanin marasa lafiya 150 a 2008. Yanzu yana fuskantar sabon gwaji, wanda aka kaddamar a shekarar 2012 a karkashin sunan Tcelna, don kimanta ta taka rawa wajen rage kwakwalwar kwakwalwa da jinkirta rashin nakasa.
NeuroVax: NeuroVax ne maganin alurar rigakafi mai maganin T-cell peptide, yana nufin cewa an sanya shi daga nau'ikan furotin wanda yayi kama da ɓangarorin T-cell pathogenic da ke kai hari ga myelin. An tsara shi don ƙarfafa jiki don yin ƙarin ƙwayoyin T da ke kula da ayyukan waɗannan kwayoyin T-wuka, ko "maras kyau".
Neurovax an allura zuwa cikin tsoka kowane mako 4. Sakamakon gwaji na gwaji na 2 na gwaji na gwaji don ƙwayoyin sclerosis na cigaba na gaba yanzu ana ci gaba da wannan maganin.
BHT-3009: An yi maganin alurar rigakafi ta DNA wanda aka kwatanta da kwayar halitta a cikin myelin cewa kwayoyin jikinsu sun kai hari, wanda ake kira furotin na asali na myelin.
Manufarta ita ce ta ƙaddamar da "canzawa" wanda ke tsara tsarin mayar da martani, a sakamakon "sake juyo" kwayoyin halittar da ke kaiwa ɗakin ɗakunan sutura a cikin mutane tare da MS.
Nazarin kimiyya ya nuna cewa maganin alurar rigakafi ne mai lafiya kuma an dakatar da shi kuma yana iya shiga gwaji na asibiti na III.
RTL1000: "RTL" takaice ne ga "haɗarin T-cell receptor recombinant," wanda shine sunadarai da suke ɗaure ga mai karɓa na T-cell da ke lalata myelin a cikin mutane tare da MS. Ta hanyar ɗaukar masu karɓar waɗannan masu karɓa, ƙwayoyin T ba su iya yin lalacewa ba. Wasu masana basu hada da wannan a cikin wasu maganin "maganin alurar riga kafi" ba yayin da wasu suka yi.
RTL1000 an gano shi mai lafiya ne kuma an yarda da shi azaman mulki guda ɗaya a cikin wani gwaji na gwaji na farko na Phase 1. Masu bincike suna shirin yin tafiya a gaba don gwada lafiyarta da tasirinsa kamar yadda ake amfani da infusions a kowane wata a gwaji na Phase 2.
Ƙarar farin ciki a Multiple Sclerosis
Wadannan maganin rigakafi sun ba da dama daga cikin mu. Haka ne, har yanzu suna cikin gwadawa kuma nesa da kasancewa ga mafi yawan mu. Duk da haka, suna da ban sha'awa sosai. Ka yi la'akari da tattaunawar su tare da likitanka kuma ka bi da gwaji a kan Cibiyar Nazari na Clinical Trials .
Sources:
Correale J, Farez M, Gilmore W. Alurar rigakafi don ƙananan sclerosis: cigaba zuwa kwanan wata. CNS Drugs. 2008; 22 (3): 175-98.
Correale J & Fiol M. BHT-3009, wani ƙwayar ƙwayar furotin na asali don maganin sclerosis da yawa. Curr Ganin Mol Ther . 2009 Agusta 11 (4): 463-70.
Ƙungiyar Sclerosis ta Amirka. (2013). Gwagun gwaji: Tcelna (tsohon Tovaxin). Sake dawowa Janairu 10th 2015.
Ƙungiyar Sclerosis ta Amirka. (2013). Gwajin gwaji: BHT-3009. Sake dawowa Janairu 19th 2015.
Yadav V et al. Tigar T-Cell Receptor Ligand (RTL) don maganin ƙwayar sclerosis mai yawa: Ƙaramar makafi guda biyu, mai gudanarwa, lokaci na 1, nazarin kashi-kashi. Autoimmune Dis . 2012; 2012: 954739.