Rawancin gwaje-gwaje na Kwance-kwance Gyara ta wurin kafa da Yawan jama'a
Sakamakon CD4 / CD8 shine kimantaccen bincike na tsarin yaduwar kwayoyin mutum , kwatanta ladaran " CD " T-cell din "mataimaki" zuwa wannan ɓangaren CD na T8. Binciken gwaji shine wanda ake nufi don gano ƙwayar cuta, kamar yadda lokacin da mutum yake ɗauke da kwayar cutar HIV .
Fahimtar yadda CD4 da CD8 T-Cells ke hulɗa
CD4 da CD8 ne kawai nau'i daban-daban na glycoprotein da aka samo akan farfajiyar T da sauran lymphocytes (jinsin jinin jini a tsakiya zuwa tsarin na rigakafi).
Kwayoyin T-CD4 suna dauke da su "masu taimakawa" saboda su ne wadanda ke haifar da amsawa ba tare da wani ɓarna ba.
Lokacin da wannan ya faru, an kunna CD-8 "masu karewa" T-ray don kai farmaki da kuma kashe waɗannan pathogens. Sai suka yi aiki ta hanyar rufe na'urar CD4 yayin da aka samu nasarar amsawa.
Ana ganin adadin CD4 / CD8 na al'ada lokacin da yake tsakanin 1.0 da 4.0. A cikin mutumin kirki wanda ke fassarawa tsakanin 30 da 60% CD4 T da kwayoyin T-cell CD8 da kashi 10-30%.
Duk da haka, idan mutum ya kamu da kwayar cutar ta HIV , yawanci yawan kwayoyin CD4 T a cikin kwayar cutar HIV ke dauke da wadannan kwayoyin kuma ya rushe lambobin su. Ya bambanta, ƙwayoyin T-CD8 za su karu da kusan kashi 40% a lokacin, kodayake ikon su na kawar da kwayar cutar zai kare a tsawon lokacin da akwai ƙananan CD-T-cell don tayar da amsa mai tasiri.
Lokacin da aka fara tayar da cutar (ART) a wani lokaci mai dacewa a cikin mutumin da ke dauke da kwayar cutar kwayar cutar HIV, asalin zai dawo cikin al'ada.
Duk da haka, idan magani ya jinkirta, ƙarfin jikin mutum na sake gyara CD-T-cell din T-raguwa ya raguwa, kuma rabo ya kasance ƙarƙashin 1.0.
Abin da CD4 / CD8 Ratio Ya Bayyana Mu
Kusan darajan CD4 / CD8 an dauke shi da mahimmanci ga gudanar da kwayar cutar HIV fiye da shekaru 20 da suka gabata, yayin da akwai misaitaccen cututtuka masu nauyin maganin HIV.
Yayinda yake iya nuna alamun shekarun kamuwa da kamuwa da hangen nesa da cutar kanjamau , yawancin da aka sanya a yau an sanya shi a kan maye gurbin maganin cututtukan kwayoyin cuta (kamar yadda aka auna ta hanyar hoto na hoto ) don rage ci gaba da cutar da kuma kauce wa ci gaban kwayar cutar HIV juriya .
Da wannan aka ce, an mayar da hankali ga girman CD4 / CD8 a cikin tsufa da cutar HIV . Binciken binciken likita na kwanan nan ya nuna cewa marasa lafiya a tasiri, dogon lokaci ART tare da raƙuman CD4 / CD8 suna da haɗari ga rashin lafiyar mutum da cutar ta HIV.
Akwai sauran wuraren da CD4 / CD8 zai iya zama mahimmanci. A binciken bincike na annoba, za'a iya amfani dasu a matsayin darajar da za a auna ma'auni (watau yiwuwar cututtukan cututtuka) na HIV a cikin mutane daban-daban ko kuma na tsawon lokaci.
Ana iya amfani da su don hango nesa da yiwuwar IRIS (ƙin sake haifar da cututtuka na ƙumburi) wanda zai iya faruwa a wani lokaci lokacin da mutum ya fara maganin antiretroviral. Idan ƙididdigar CD4 na ƙasƙanci ba ta da ƙasa kuma an haɗa shi tare da raƙuman CD4 / CD8 a ƙasa 0.20, chances na taron IRIS yana ƙaruwa sosai.
Hakazalika, bincike ya nuna cewa CD4 / CD8 mai ƙananan kididdiga a cikin jariran da aka haife su ga iyaye masu kamuwa da kwayar cutar HIV yana da tsammanin ko yarinyar za ta janye (tabbatar da cutar HIV) , tare da yiwuwar kara ƙaruwa yayin da rabo ya kasance ƙasa 1.0.
Wannan na iya zama mai dacewa a kasashe masu tasowa inda yawancin yarinyar yaran ya karu da yawa amma yawan adadin yara HIV dauke da kwayar cutar a kan ART ya kasance mai girma.
Sources:
Mahnke, Y. Greenwald, J .; DerSimonian, R .; et al. "Ƙarar zaɓuɓɓuka na CD4 Turarrun cututtuka na kamuwa da cutar ta HIV-1 wanda ke dauke da kwayar cuta mai ƙwayar cuta." Jinin jini. Maris 29, 2012; 119 (13): 3105-3112.
Zijenah, L ;; Katzenstein, D .; Nathoo, K .; et al. "T lymphocytes daga cikin kwayar cutar HIV da kuma kananan yara: CD4 / CD8 rabo ne a matsayin kayan aiki mai yalwacin ganowar kamuwa da yara a cikin shekaru 2." Journal of Translational Medicine. 1 Fabrairu 2005; 3: 6: Doi: 10.1186 / 1479-5876-3-6.
Seng, R. Goujard, C .; Krastinova, E; et al. "Rashin rinjayar cutar kanjamau ta tsawon rayuwa mai tsawo a kan tsararren CD4 + da CD4 + / CD8 + a tsakanin marasa lafiya a hade da maganin cutar antiretroviral." AIDS . Janairu 13, 2015; wallafa a gaban bugawa; DOI: 10.1097 / QAD.0000000000000571.