Na farko shekaru 20: 1984-2003
Tarihin farko na ciwon maganin rigakafi na HIV shine daya daga bege da alkawuran. A lokacin da aka gano kwayar cutar ta HIV, masana kimiyya, 'yan siyasa da masu gwagwarmaya sunyi imani da cewa maganin cutar AIDS ya kasance daidai a kusurwa. Akwai masu saɓo, amma mafi yawa akwai alkawuran. Ya ɗauki shekaru kafin a yi tsammanin maye gurbinsa da jin kunya. Yi amfani da wannan lokaci don koyi game da tarihin shekaru 20 da suka gabata na ci gaban maganin rigakafin HIV.
1984
An gano HIV-1. AIDS ba abu ne mai rashin asiri ba. Masana kimiyya sun fara fata zasu iya inganta maganin alurar rigakafi don kare lafiyar cutar da aka sani da, a tsakanin sauran abubuwa, "Labaran Gida."
A yayin taron manema labarai na watan Afrilu, Sakataren Lafiya na Amurka Margaret Heckler ya furta cewa dole ne a saran rigakafin HIV don gwaji a cikin shekaru biyu.
1985
Ciwon maganin rigakafi na HIV ya fara da gaske. Abin takaici, masana kimiyya suna fuskantar matsaloli. Ya nuna cewa cutar HIV tana da kyau sosai don tsayayya da mafi yawan hanyoyi na ci gaban maganin alurar rigakafi.
1986
Na farko cutar rigakafin HIV an yarda don gwaji na asibiti.
1987
Wani labarin a cikin mujallolin Nature ya ruwaito cewa duk samfurori a cikin maganin maganin alurar rigakafi sun kamu da kwayar cutar HIV ko da yake sun ci gaba da ci gaba da cutar da kwayar cutar T ta hanyar magance kwayoyin cutar ta HIV bayan sun sami maganin. A cikin tsammanin, wannan hasara ce.
An kafa Cibiyar Harkokin Gudanar da Ƙwararren Ƙungiyar AIDS (ACTG) don samar da cibiyar sadarwa na shafukan gine-ginen da za a iya amfani dasu don nazarin maganin HIV.
Na farko gwaji na asibiti na kwayar cutar HIV ya fara a Amurka. Wannan gwajin lafiya na wannan lokaci ya sa hannu ga masu lafiya, marasa lafiya marasa lafiya kuma basu gano cewa maganin alurar riga kafi ba shi da tasiri mai tsanani.
1988
Kungiyar Rarraba Ciwon Kankara ta AIDS (AVEG) fara farawa masu aikin sa kai.
1989
Masana kimiyya sun sanar da ci gaba da ci gaban kwayar cutar SIV (simian immunodeficiency virus) wanda ke kare kananan ƙwayoyin birai daga kamuwa da cuta.
1990
Wata kasida a mujallar Fortune ta ce akwai yiwuwar zama rigakafin rigakafin rigakafi kafin 1993.
1991
Shirin rigakafi na Pasteur-Merieux Connaught ya fara.
An tabbatar da maganin cutar kanjamau na farko da aka gwada a Amurka.
A ƙarshen shekara, an ba da takardun shaida 26 don maganin rigakafi na HIV.
1992
Na farko na shirin na NIH da aka tallafa masa na biyu na gwaji na rigakafi na HIV. Yana shigar da mutane masu haɗari kuma ya shawarce su don kauce wa halayen halayya.
AVEG fara fara gwajin maganin alurar rigakafi na farko - an tsara shi don rage ci gaban ci gaba maimakon hana rigakafin HIV. Yana sanya 55 maza da mata masu fama da cutar HIV.
1993
Na farko maganin rigakafin maganin alurar rigakafi da ya hada da yara masu kamuwa da HIV da ke dauke da kwayar cutar HIV da suka kamu da cutar.
Na farko na rigakafi na NAIAID na maganin rigakafi na HIV don shigar da mutanen da cutar HIV ta ci gaba.
Ƙungiyar Lafiya ta Duniya da Gwamnatin Thailand sun hada kai don samar da shirin kasa don maganin rigakafi na HIV.
Massachusetts ya sanar da shari'ar da aka dauka ta farko game da maganin rigakafin cutar HIV.
1994
NIH ta kafa jagororin da suka shiga cikin gwaje-gwaje na asibiti.
Na farko na maganin rigakafin cutar HIV a cikin Asiya ya fara.
1995
Shawarar shawarwari na kwamitin don aika da maganin rigakafi na HIV a cikin gwaji na asibiti na III.
1996
Sashe na III na gwajin Salk, wanda ake kira Remune, fara shiga cikin Amurka da Thailand.
An kirkiro shirin na rigakafin cutar kanjamau (IAVI).
Kwayar rigakafi ta gp160 ya cika nasara, amma ya kasa hana HIV ko rage jinkirin cutar.
1997
Shugaba Bill Clinton ya kafa manufar inganta wata rigakafin HIV a cikin shekaru 10. Yayin da yake magana da wata ƙungiyar dalibai a Jami'ar Jihar ta Jihar Morgan, ya ce "Ba tambaya bane ko za mu iya ci gaba da maganin cutar AIDS, wannan tambaya kawai ne lokacin.
Kuma ba zai iya zo wata rana ba da jimawa ba, "kuma ya yi alkawalin kafa cibiyar nazarin maganin rigakafi ta kwayar cutar HIV a Cibiyoyin Lafiya na Ƙasar.
Fiye da 95 gwajin maganin rigakafi na HIV an kammala.
Fiye da maza biyu da mata 2,000 sun shiga cikin maganin maganin rigakafi na kwayar cutar HIV a gwajin gwajin maganin cutar ta HIV
Majalisar UNAIDS ta shirya taron don tattauna batutuwan da ke tattare da yin nazarin maganin rigakafin HIV a kasashe masu tasowa.
1998
Vaxgen ya fara samfurin III na jaririn HIV vaccin HIV.
1999
Kwamitin Kula da Tsaron Bayanan Tsaro ya ƙare ƙarshen gwaje-gwajen na Mataki na III wanda ba a nuna bambanci tsakanin maganin alurar riga kafi da kungiyoyi.
Kasar Uganda ta zama wurin shari'ar cutar ta HIV ta farko ta Afirka.
Vaxgen fara farawa don gwajin AIDSVAX a Thailand.
2000
An kafa cibiyar sadarwa na gwaji ta HIV. HVTN wani haɗin kai ne na jama'a da masu zaman kansu na masu bincike na rigakafin. Yana da hedkwatar Cibiyar Nazarin Ciwon Binciken Fred Hutchinson a Seattle, kuma NIH ta tallafa masa.
UNAIDS ta shafi wani jagorar jagorancin kayan aikin maganin cutar kanjamau a kasashe masu tasowa.
Wani gwajin rigakafin rigakafi na HIV ya fara a kasar Kenya.
Wani lokaci zan gwada maganin rigakafi na DNA wanda ke tsirara.
2001
Masu bincike na NIH sun sadu da kungiyoyin jama'a don gano yadda matasa ke shiga gwajin maganin cutar kanjamau.
Mayar daftarwar Mayu daga HVTN ta sanar da cewa suna da gwaje-gwaje na rigakafin kwayar cutar HIV guda hudu, tare da wani wanda aka shirya don farawa a cikin shekara.
An sami jarrabawar dabarun Firayim-Boost don nuna alkawari a birai.
2002
AIDSInfo yana rayuwa.
GlaxoSmithKline ya sanar da cewa zai fara gwajin gwaji na maganin cutar HIV a kan NefTat da gp120.
Merck ya fara farautar gwaji na maganin alurar riga kafi.
2003
Ana sanar da cewa gwajin AIDSVAX a Thailand ya kasa.
Kwayar maganin cutar HIV-1090 na shiga cikin gwaji na farko. Alurar rigakafi ya ƙunshi 21 da aka tsara halittar DN DNA a jikin wasu sassa daban-daban na cutar da aka kare sosai. Manufarta ita ce ta da'awar mayar da martani ga T cell. Yana da dan takarar rigakafi na farko na cutar kanjamau da za a yi nazari a lokaci daya a Amurka da kasashen waje.
- Sanin Cytotoxic T Lymphocytes
Merck da kungiyar Aventis har zuwa gwada kwayoyin cutar su a wuraren shafuka 18.
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Deeks SG da Walker BD "Masu Gudanar da Cutar Gidawar Dan Adam: Tsarin Magungunan Kwayoyin cuta na Kwayoyin cuta a cikin Rashin Magungunan Kwayoyin cuta" Immunity. 2007; 27: 406-16.
Dolgin E. "Sabbin burin na ba da bege ga maganin rigakafin HIV" Nature News. Satumba 3. 2009. (An shiga yanar gizo 10/1/09)
Miedema F. "Wani ɗan gajeren tarihin bincike kan maganin rigakafin kwayar cutar HIV: yana komawa zuwa zane?" AIDS. 2008 Satumba 12; 22 (14): 1699-703.
Murphey-Corb M et al. "Kwayoyin maganin SIV wanda ba ya aiki ba tare da izini ba ya ba da kariya ga macaques" Kimiyya. 1989 Dec 8; 246 (4935): 1293-7.
Walker BD, Burton DR. "Kwayar maganin cutar AIDS." Kimiyya. 2008 Mayu 9; 320 (5877): 760-4.
Gwaji na Clinical na HIV HIV - NIAID Fact Sheet. http://www.niaid.nih.gov/factsheets/clinrsch.htm (An shiga 10/1/09)
HVTN Fact Sheet. http://www.hvtn.org/media/FactSheet.pdf (An shiga 10/1/09)
WHO: Taron farko na Shirin Ciwon Kanjamau na AIDS na Afirka http://www.who.int/mediacentre/news/releases/2005/pr53/en/index.html (An shiga 10/1/09)
AIDS List of Trials List. http://aidsinfo.nih.gov/Vaccines/MainSearch.aspx?strPreventive=on&strTherapeutic=on&strSponsor=All&strRecruiting=on&status=1&strNoRecruiting=on&NRstatus=1 (Samun damar 10/1/09)
AIDS AIDS News Press release: HIV / AIDS Vaccines http://www.aidsinfo.nih.gov/aprs/release.aspx?an=A00070 (Samun damar 10/1/09)
AEGIS Fact Sheet - Cibiyar Bincike ta HIV / AIDS Vaccineshttp: //www.aegis.org/factshts/NIAID/1997/niaid97_fact_sheet_clinrsch.html (Samun damar 10/1/09)
TAMBAYOYIN BAUTAWA YADDA ZUWA YAKE YA BA YA KASA KASA A CIKIN 1993. Wasu kwayoyi da suke samuwa da sauri zasu jinkirta ko ma dakatar da cutar ba tare da sakamakon AZT ba. Fabrairu 26, 1990 Labari na Fortune. http://money.cnn.com/magazines/fortune/fortune_archive/1990/02/26/73115/index.htm (Online Accessed 10/1/09)
Binciken Bincike na Kanjamau na Kanjamau - shekara ta 2005 a Bincike. Janairu 2006 • Vol.4 • No.1 http://www.iavi.org/lists/iavipublications/attachments/11b8f27a-4f78-4a9f-9e52-167f3f522901/iavi_vax_table_jan_2006_eng.pdf (An samu damar 10/1/09)