Angiogenesis da masu hanawa a Ciwon Cutar Cancer
Ma'anar: Angiogenesis
Angiogenesis yana nufin kasancewar sabon jini a jiki. Yana da hanyar al'ada don warkar amma yana taka rawar gani a ci gaban ciwon daji.
Angiogenesis a Lafiya da Waraka
Angiogenesis abu ne na al'ada wanda ke faruwa cikin jiki a kowane hali wanda ake buƙatar ci gaba da sabon jini.
Saboda haka, ya wajaba ga yara suyi girma, don yaduwar mahaifa ta yi girma a kowane wata a cikin matan auren mata, da kuma raunuka don warkewa.
Angiogenesis a Ciwon daji da Metastasis
Angiogenesis yana da sha'awar ciwon daji saboda cututtuka na buƙatar samun sabon jini don yayi girma da kuma gamsuwa. Domin ciwon daji ya yi girma ya zama mai girma fiye da millimita daya (angogenesis) ya kamata ya faru. Cancers yi haka ta hanyar ɓoye abubuwa da ke motsa angiogenesis, sabili da haka, ci gaban ciwon daji.
Bugu da ƙari, kasancewa tsarin da ake bukata don ciwon daji ya yi girma da kuma tsayayya da ƙwayoyin da ke makwabta, yana da muhimmanci don matakan da za su faru . Domin ciwon daji na tafiya da kuma kafa sabon gida a wani wuri ba tare da asalin su ba, waɗannan kwayoyin suna buƙatar kawo sabon jini don tallafawa ci gaban su a sabon wurare.
Angiogenesis da ƙananan ƙananan ƙarewa na Endothelial (VEGF)
Jirgin jini yana kunshe ne daga sel da ake kira ciwon endothelial a cikin cikin tasoshin.
Abubuwa da aka sani da ci gaban kwayoyin halitta, VEGF don takaice, sun kasance sakonni wanda zai taimaka wa kwayoyin endothelial girma da kuma haifar da sabon jini. A wasu kalmomi, su masu kunnawa ne. Jigilar jini cikin jiki, kamar ayyuka da yawa, shine ma'auni na kunnawa da kuma tasiri.
Magungunan Angiogenesis
Masu hana maganin Angiogenesis sune nau'i ne na hanyoyin magance cutar , wanda ke nufin sun danganta ƙwayoyin ciwon daji ko kuma kwayoyin da suka dace don ci gaban ko yaduwar ciwon daji.
Wadannan magunguna na iya tsoma baki tare da aiwatar da angiogenesis a wurare daban-daban. Wasu daga cikin waɗannan suna hanawa ta hanyar daurin nauyin haɓakar ƙarancin ƙananan ciwon ƙwayar cuta (VEGF) don haka ba zai iya nuna siginan ɗakunan endothelial ba, don haka sun dakatar da kafa sabon jini.
Misalan masu maganin Angiogenesis
Wasu masu hana maganin angiogenesis wanda ke samuwa yanzu don magance ciwon daji sun hada da:
- Avastin (bevacizumab)
- Nexavar (Sorafenib)
- Sutent (sunitinib)
- Budurwa (pazopanib)
- Abokan baki (everolimus)
Ƙara koyo game da immunotherapy da kuma yadda masu maganin angiogenesis ke aiki don magance ciwon daji.
Angiogenesis Inhibitors Plus Chemotherapy
Tambayar tambaya ita ce dalilin da ya sa mutane zasu buƙatar shan magani a cikin banda magungunan angiogenesis. Dubi hanyar da masu maganin angiogenesis ke taimakawa wajen bayyana wannan. Masu hana maganin Angiogenesis ba su kashe cututtuka ba, suna yin aiki kawai don hana su girma da kuma yada (metastasizing), saboda haka don kawar da kwayar cutar, dole ne ayi amfani da cutar shan magani a hade tare da masu maganin angiogenesis.
Hanyoyi na gefen Angogenesis Masu hana
Lokacin da aka gano magunguna na angiogenesis a matsayin magani ga ciwon daji, an yi zaton za su sami komai.
Wannan ba haka bane. Kamar dai yadda chemotherapy zai haifar da tasiri ta hanyar aikatawa a kan kwayoyin halitta (alal misali, ta dakatar da sassan jiki a cikin gashin gashi, da kasusuwan kasusuwan, da kuma gastrointestinal tract) angilagenesis masu hanawa na iya haifar da sakamako masu illa da suka danganci aikin su a cikin kwayoyin lafiya da kyallen takalma. Wasu daga cikin alamun da suka fi dacewa sune dangantaka da:
- Raunin rauni mara kyau tun lokacin da masu hana masu ciwon angiogenesis ba kawai suke tsangwama tare da iyawar ciwon daji don yin sabon jini ba amma har da tsangwama tare da iyawar kyallen lafiya don yin sabon jini don maye gurbin wani rauni.
- Zanewa a cikin arteries, wanda hakan zai haifar da hare-haren zuciya da shanyewa.
- Hawan jini.
Dalilai na Goma / Na Gida
Magunguna da yawa a cikin wannan rukunin suna kimantawa a gwaje-gwaje na asibitoci, kuma akwai begen cewa tayar da ciwon daji daga tsinkayar magance angiogenesis zai kasance wani ɓangare na ƙarin maganin ciwon daji a cikin gaba.
Sources:
Ƙasar Amirka ta Cibiyar Nazarin Harkokin Kwayoyi. Cancer.Net. Angiogenesis da Angiogenesis Masu hanawa don magance cutar. 07/2014. http://www.cancer.net/navigating-cancer-care/how-cancer-treated/personalized-and-targeted-therapies/angiogenesis-and-angiogenesis-inhibitors-treat-cancer
Cibiyar Cancer ta Kasa. Magungunan Angiogenesis. Updated 10/07/11. https://www.cancer.gov/about-cancer/treatment/types/immunotherapy/angiogenesis-inhibitors-fact-sheet